2012
DOI: 10.5301/ejo.5000193
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Glaucoma Progression Detection: Agreement, Sensitivity, and Specificity of Expert Visual Field Evaluation, Event Analysis, and Trend Analysis

Abstract: The 3 methods detected similar numbers of progressing cases. The GPA event analysis and expert subjective assessment showed high agreement between them and moderate agreement with GPA trend analysis. In a period of 3 years, both methods of GPA analysis offered high specificity, event analysis showed 83% sensitivity, and trend analysis had a 66% sensitivity.

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Cited by 26 publications
(14 citation statements)
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“…1113 Event and trend-based progression analyses showed similar sensitivity and specificity but moderate agreement. 14 However, VF tests are difficult for some patients and are known to have increased variability, especially in patients with advanced disease. 15 The between-visit reproducibility of VF mean deviation ranges from 0.6 to 1.2 dB (standard deviation) from early to advanced glaucoma, which translates to a coefficient of variation (CV) of approximately 13 to 28% when the dB (logarithmic) units are converted to linear sensitivity.…”
Section: Introductionmentioning
confidence: 99%
“…1113 Event and trend-based progression analyses showed similar sensitivity and specificity but moderate agreement. 14 However, VF tests are difficult for some patients and are known to have increased variability, especially in patients with advanced disease. 15 The between-visit reproducibility of VF mean deviation ranges from 0.6 to 1.2 dB (standard deviation) from early to advanced glaucoma, which translates to a coefficient of variation (CV) of approximately 13 to 28% when the dB (logarithmic) units are converted to linear sensitivity.…”
Section: Introductionmentioning
confidence: 99%
“…However other authors 1,14 have obtained higher rates of sensitivity for GPA II when the reference standard comprised experts using objective systems to detect progression such as those of Hodapp et al 15 or Boden et al 16 based on pattern deviation plot. Pattern deviation analysis may underestimate the number of cases with progression since it does not detect diffuse changes of glaucomatous progression [17][18][19] or changes in very advanced cases where thresholds are very low or out of range; 14 it may also detect progression in cases of perimetric fluctuation. The inability to detect atypical or initial diffuse glaucomatous progression 5 and changes in advanced glaucoma, coupled with the use of very strict criteria to detect progression explains why GPA II in our work presented low sensitivity when compared to a reference standard using subjective criteria of progression.…”
Section: Discussionmentioning
confidence: 99%
“…We reviewed literature to see the reliability of our approach. Anton et al [33] studied progression assessed subjectively by glaucoma experts, and by GPA event analysis and GPA trend analysis. They reported high agreement between the GPA event analysis and expert subjective assessment, and moderate agreement with GPA trend analysis.…”
Section: Discussionmentioning
confidence: 99%