Gleason score 7 prostate cancer: a heterogeneous entity? correlation with pathologic parameters and disease-free survival

Sakr, Wael; Tefilli, Marcos V.; Grignon, David J.; Banerjee, Mousumi; Dey, Jyotirmoy; Gheiler, Edward L.; Tiguert, Rabi; Powell, Isaac J.; Wood, David P.

doi:10.1016/s0090-4295(00)00791-3

Cited by 129 publications

(73 citation statements)

References 9 publications

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“…According to the literature, the prognosis of patients with GS 4þ3 prostate cancer is worse than that of patients with GS 3þ4 prostate cancer (18). Thus, we assessed whether there was a statistically significant difference between ADC values in patients with GS 4þ3 and those with GS 3þ4 prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Clinical utility of apparent diffusion coefficient (ADC) values in patients with prostate cancer: Can ADC values contribute to assess the aggressiveness of prostate cancer?

Itou

Nakanishi

Narumi

et al. 2010

Magnetic Resonance Imaging

111

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Purpose: To retrospectively evaluate the relationship between apparent diffusion coefficient (ADC) values and Gleason score (GS) in prostate cancer.Methods: A total of 60 patients who underwent radical prostatectomy for clinically localized prostate cancer were selected for this study. Diffusion-weighted magnetic resonance (MR) images were obtained using a 1.5 T system. ADC values were analyzed between three groups: GS of 6 or less (n ¼ 7); GS of 7 (n ¼ 37); and GS of 8 or higher (n ¼ 16). ADC values of the three GS groups were statistically analyzed in order to determine the relationship with GS. In the 37 patients with GS ¼ 7 the difference in ADC values between GS 3þ4 and GS 4þ3 was analyzed. Results: Median ADC values (10À3 mm 2 /s) of the three GS groups were 1.04 (GS ¼ 6 or less), 0.867 (GS ¼ 7), and 0.729 (GS ¼ 8 or higher). Although there was considerable overlap among the groups, the differences in ADC were statistically significant (P < 0.0001). There was a significant inverse correlation between GS and ADC values (z ¼ À0.437, P < 0.0005). Median ADC values (10 À3 mm 2 /s) of GS 3þ4 and GS 4þ3 patients were 0.88 and 0.814, respectively (P < 0.05). Conclusion: ADC values showed a negative correlation with GS. Pathologically, however, there was considerable intrasubject heterogeneity.

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Section: Discussionmentioning

confidence: 99%

Clinical utility of apparent diffusion coefficient (ADC) values in patients with prostate cancer: Can ADC values contribute to assess the aggressiveness of prostate cancer?

Itou

Nakanishi

Narumi

et al. 2010

Magnetic Resonance Imaging

111

View full text Add to dashboard Cite

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“…30]; however, the lack of statistical significance in that study might be ascribale to there being too few patients and the inclusion of patients with positive lymph nodes and/or seminal vesicle invasion. In another study [31] Gleason score 3 + 4 or 4 + 3 correlated with both stage and progression, but the median follow-up was only 25.8 months and the difference between the scores was independently predictive only in men with serum PSA values of < 10 ng/mL and in those with organ-confined disease.…”

Section: Gleason Scores In Rp Specimensmentioning

confidence: 90%

Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies

et al. 2005

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The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other pathological variables, including tumour volume and margin status in radical prostatectomy specimens, serum prostate‐specific antigen levels and many molecular markers. The Gleason score assigned to the tumour at radical prostatectomy is the most powerful predictor of progression after radical prostatectomy. However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts.

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“…The recurrences of the patients after radical prostatectomy in many literatures were quite different, because of the number of cases, follow-up period, surgical techniques and diagnostic criteria of biochemical recurrence were different. Sakr et al [32] studied 534 patients after radical operation and found the biochemical recurrence of the patients was 40%. Recently, Ricethe et al have reported that biochemical recurrence rate is 24.2%-38.5% among 1 159 patients after radical prostatectomy [33].…”

Section: Discussionmentioning

confidence: 99%

Application of histone modification in the risk prediction of the biochemical recurrence after radical prostatectomy

Zhou

Li²,

Huang³

et al. 2009

Asian J Androl

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The role of histone modifications in the development and progression of cancer remains unclear. Here, we gave an investigation of the relationship between the various histone modifications and the risk prediction of the biochemical recurrence after radical prostatectomy (RP). Histone 3 lysine 4 dimethylation (H3K4diMe), trimethylation (H3K4triMe), lysine 36 trimethylation (H3K36triMe), histone 4 lysine 20 trimethylation (H4K20triMe) and acetylation of histome 3 lysine 9 (H3K9Ac) were evaluated using immnuohistochemistry coupled with the tissue microarray technique in 169 primary prostatectomy tissue samples. Recursive partitioning analysis (RPA) was used to analyze the data. Through global histone modification analysis in patients who underwent radical prostatectomy, we found that H3K4triMe can predict the risk of the biochemical recurrence for the low grade prostate cancer (Gleason score ≤ 6) after RP. In the case of high grade prostate cancer (Gleason score ≥ 7), H4K20triMe and H3K9Ac accompanying with the pre-operation prostate-specific antigen (PSA) level could also predict the risk of the biochemical recurrence after RP. In combination with the Gleason score and pre-operation PSA level, the acetylation and methylation of histones H3 and H4 can predict the biochemical recurrence of the prostate cancer following RP.

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Gleason score 7 prostate cancer: a heterogeneous entity? correlation with pathologic parameters and disease-free survival

Cited by 129 publications

References 9 publications

Clinical utility of apparent diffusion coefficient (ADC) values in patients with prostate cancer: Can ADC values contribute to assess the aggressiveness of prostate cancer?

Clinical utility of apparent diffusion coefficient (ADC) values in patients with prostate cancer: Can ADC values contribute to assess the aggressiveness of prostate cancer?

Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies

Application of histone modification in the risk prediction of the biochemical recurrence after radical prostatectomy

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