“…According to the role of M2 polarity in increasing angiogenesis [ 49 , 51 ], a raised angiogenesis in the INTRCPZ group was observed that was accompanied by an increased M2 phenotype in this group. Although cuprizone model is not a facsimile of multiple sclerosis, however, Rashid et al proposed a raised perfusion in RRMS against hypoperfusion in PPMS patients [ 52 ].…”