Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave

Abstract

INTRODUCCIÓN El estado nutricional materno antes y durante la gestación tiene un gran impacto en los resultados materno-fetales (1). El hierro es un nutriente esencial, cofactor de diferentes enzimas del metabolismo (2), necesario para la síntesis de neurotransmisores y la mielinización del sistema nervioso (3) y un componente básico de la hemoglobina y la mioglobina (2). Las alteraciones en el estado de hierro materno durante la gestación se han asociado a enfermedades desde la anemia ferropénica hasta la preeclampsia. La anemia, diagnosticada por una reducción en la concentración de hemoglobina materna (<11g/dl) y de la ferritina sérica (<15ug/L) (4), disminuye la capacidad de trabajo en la madre, aumenta el riesgo de infecciones y el tiempo de tratamiento (5). En el feto, la anemia se ha asociado con restricción de crecimiento intrauterino (RCIU),

Glycosylation Profile of the Transferrin Receptor in Gestational Iron Deficiency and Early-Onset Severe Preeclampsia

“…Placental TfR1 expressed α 2-3 sialic acid instead of α 2-6 sialic acid and a tendency of overexpression of α 2-3 sialic acid was observed in preeclamptic placentas. According with our previous findings, placental protein extracts from preeclamptic placentas are highly sialylated [31], including those linked to α 2-6 position. Van den Eijnden et al have proposed a low expression of α 2-6 sialyltransferase as a possible explanation of the reduced α 2-6 sialic acid in the TfR1 glycoprotein [59].…”

“…Previously, we found changes in the glycosylation profile of trophoblastic villi in women with preeclampsia compared with normal gestation [31]. In the present study, we sought to investigate whether changes occur in the glycosylation profile of TfR1 in placentas from women with preeclampsia.…”

Expression of placental glycans and its role in regulating peripheral blood NK cells during preeclampsia: a perspective

“…Additionally, alterations in iron status have been associated with hypertensive disorders of pregnancy ( 168 – 171 ). Glycosylation profiles induced by hypoxia and placental inflammation have been proposed to alter the exchange of macronutrients and micronutrients across the syncytiotrophoblast ( 172 , 173 ). Iron is transferred from the mother to the fetus via the placenta after being taken up by TfR1 at the apical membrane of the syncytiotrophoblast ( 174 – 177 ).…”