Gliclazide-induced acute hepatitis

Dourakis, Spyros P.; Tzemanakis, Eftichios; Sinani, Chrisanthi; Kafiri, Georgie; Hadziyannis, Stephanos J.

doi:10.1097/00042737-200012010-00021

Cited by 30 publications

(16 citation statements)

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“…The liver demonstrated cholestasis, bile-duct proliferation, and panacinar necrosis consistent with a hypersensitivity drug reaction. Similar cases of non-fatal hepatitis consistent with a hypersensitivity reaction have been reported with glyburide [3] and gliclazide [4]. In all four cases, liver enzymes were only moderately elevated and only the patient treated with glipizide manifested hepatic failure.…”

supporting

confidence: 75%

Glipizide treatment with short-term alcohol abuse resulting in subfulminant hepatic failure

2003

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supporting

confidence: 75%

Glipizide treatment with short-term alcohol abuse resulting in subfulminant hepatic failure

2003

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“…Two case reports (one French 2and one Greek 3) of gliclazide‐induced acute hepatitis have been reported. Our case is the first report in English literature of hepatitis thought to be most likely associated with gliclazide.…”

Section: Discussionmentioning

confidence: 99%

Gliclazide‐induced hepatitis

2003

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A 64-year-old man presented with tiredness, and a diagnosis of type 2 diabetes was made based on two raised random blood glucose values. He was commenced on gliclazide. Three months later, blood investigations revealed elevated liver enzymes (hepatitic pattern). Further investigations revealed no obvious cause for his abnormal liver function tests. Gliclazide was discontinued and a subsequent liver biopsy revealed features consistent with an acute hepatitis. His liver function tests returned to normal three months after discontinuation of gliclazide.

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“…Drug-induced hepatotoxicity has been reported infrequently with various sulfonylureas used as glucose-lowering agents for the management of T2DM : chlorpropamide [120], tolazamide [121], glibenclamide (glyburide) [122][123][124], glimepiride [125], and gliclazide [126,127].…”

Section: 2sulfonylureasmentioning

confidence: 99%