Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival

Abstract

ObjectiveTo determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).Methods502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imaging Atlas (n=250) were independently reviewed. The shortest distance from the tumor contrast enhancement to the nearest lateral ventricular wall, the location of the VSVZ, was measured (GBM-VSVZDist). The relationship of GBM-VSVZDist with the proportion of glioblastomas at each distance point and overall survival was explored with a Pearson’s correlation and Cox regression model, respectively, adjusting for the well-established glioblastoma prognosticators.Results244/502 glioblastomas had VSVZ contact. The proportion of non-VSVZ-contacting glioblastomas correlated inversely with GBM-VSVZDist (partial Pearson’s correlation adjusted for tumor volume R=-0.79, p=7.11x10-7). A fit of the Cox regression model adjusted for age at diagnosis, Karnofsky performance status score, post-operative treatment with temozolomide and/or radiotherapy, IDH1/2 mutation status, MGMT promoter methylation status, tumor volume, and extent of resection demonstrated a significantly decreased overall survival only when glioblastoma contacted the VSVZ. Overall survival did not correlate with GBM-VSVZDist.ConclusionsIn the two independent cohorts analyzed, glioblastomas at diagnosis were found in close proximity or in contact with the VSVZ with a proportion that decreased linearly with GBM-VSVZDist. Patient survival was only influenced by the presence or absence of a gadolinium-enhanced glioblastoma contact with the VSVZ. These results may guide analyses to test differential effectiveness of VSVZ radiation in VSVZ-contacting and non-contacting glioblastomas and/or inform patient selection criteria in clinical trials of glioblastoma radiation.

Prognostic analysis and nomogram construction for older patients with IDH-wild-type glioblastoma

“…Our study showed that SVZ involvement is a negative prognostic factor of PFS for older IDH-wild-type glioblastoma in univariate and multivariate analyses and an unfavourable prognostic factor of OS in univariate analysis but not an independent prognostic factor of OS in multivariate analysis. Mistry et al [ 62 ] analysed the relationship between the distance to the lateral ventricular wall from glioblastoma and the survival outcome of 502 glioblastoma patients, and the results showed a significantly decreased overall survival only when glioblastoma contacted the lateral ventricular wall. OS did not correlate with distance to the lateral ventricular wall from glioblastoma.…”

C-C motif chemokine ligand 2/C-C receptor 2 is associated with glioma recurrence and poor survival

“…The inclusion criteria were as follows: i) All the cases were solitary lesions and pathologically diagnosed as glioma (2016 WHO classification of tumors of the central nervous system ( 3 )); ii) both the first and second operations were performed in Qilu Hospital; iii) cranial MRI was performed after the first operation with detection of enhanced new lesions, or >25% larger than before, iv) the expected survival time was >8 weeks and v) the Karnofsky score (KPS) was >60( 26 ). Patients with irradiation necrosis were excluded.…”

Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions

“…This may be due to the fact that NSCs in SVZ can leave the niche and migrate over long distances to promote tumor relapse, and GBM exposed to SVZ are closely related to cerebrospinal fluid, which circulates and spreads tumor cells to distant locations [ 25 ]. Studies have shown that GBM patients exposed to SVZ have a higher expression rate of CD133 (a GBM biomarker related to radiation resistance expressed by both NSCs and GSCs) than those not exposed [ 36 , 38 – 40 ]. Therefore, CD133 expression by NSCs in SVZ may be a factor in the high recurrence and poor prognosis of GBM.…”