Glioblastoma: State of the Art of Treatments and Applications of Polymeric and Lipidic Nanomedicines

Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol

“…One of the topical areas of application of polymer self-organizing systems is the creation of polymerosomes as synthetic carriers of bioactive compounds, including anticancer, antiviral, antimicrobial agents, and genetic material (DNA and RNA). , Encapsulation of target substrates due to covalent bonding, ionic, or hydrophobic interaction allows us to ensure controlled distribution between organs and tissues, achievement of therapeutic concentration to the target organ, crossing the blood–brain barrier, and membrane protective systems, under conditions of pathogenic cells’ drug resistance. , In addition to the ability to self-organize and encapsulate target substrates, the polymer carrier system must be biocompatible, biosimilar, and biodegradable, and its bioactivity should not reduce the activity of therapeutic agents (drug, DNA, RNA).…”

High potency EDC-crosslinked bovine serum albumin nanoencapsulation of berberine enhances in vitro anticancer efficacy against glioblastoma by inducing ROS mediated cell apoptosis

“…Also, the poor response and resistance to conventional radiotherapy and chemotherapy of GBM demand for the development of innovative and effective treatment modalities. 3,4,5,6 The majority of clinical chemotherapeutic medicines have extremely limited applications due to their poor solubility, non-specific distribution, quick elimination, and systemic toxicity, thereby compromising the effectiveness of the treatment and resulting in adverse side effects. 7 Furthermore, the administration of therapeutic molecules is more challenging in glioma as compared to other cancers because of the blood-brain barrier (BBB).…”