Gliogenic and neurogenic progenitors of the subventricular zone: Who are they, where did they come from, and where are they going?

Marshall, Christine A. G.; Suzuki, Satoshi; Goldman, James E.

doi:10.1002/glia.10213

Cited by 136 publications

(111 citation statements)

References 107 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Because many astrocytes of the forebrain originate postnatally from progenitors in the SVZ (Marshall et al, 2003), for review we examined the effects of expressing ATF5 or Azip-ATF5 in SVZ cells, first in culture and then in vivo. For culture studies, we dissected the SVZ from the P1 rat forebrain, dissociated the cells, and immunopanned with an anti-PSA-NCAM antibody.…”

Section: Atf5 Represses and Azip-atf5 Leads To Astrocytic Differentmentioning

confidence: 99%

See 1 more Smart Citation

Downregulation of Activating Transcription Factor 5 Is Required for Differentiation of Neural Progenitor Cells into Astrocytes

Angelastro¹,

Mason²,

Игнатова³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

The mechanisms that regulate neural progenitor cell differentiation are primarily unknown. The transcription factor activating transcription factor 5 (ATF5) is expressed in neural progenitors of developing brain but is absent from mature astrocytes and neurons. Here, we demonstrate that ATF5 regulates the conversion of ventricular zone (VZ) and subventricular zone (SVZ) neural progenitors into astrocytes. Constitutive ATF5 expression maintains neural progenitor cell proliferation and blocks their in vitro and in vivo differentiation into astrocytes. Conversely, loss of ATF5 function promotes cell-cycle exit and allows astrocytic differentiation in vitro and in vivo. CNTF, a promoter of astrocytic differentiation, downregulates endogenous ATF5, whereas constitutively expressed ATF5 suppresses CNTF-promoted astrocyte genesis. Unexpectedly, constitutive ATF5 expression in neonatal SVZ cells both in vitro and in vivo causes them to acquire properties and anatomic distributions of VZ cells. These findings identify ATF5 as a key regulator of astrocyte formation and potentially of the VZ to SVZ transition.

show abstract

Section: Atf5 Represses and Azip-atf5 Leads To Astrocytic Differentmentioning

confidence: 99%

“…Presumably, SVZ cells arise from local VZ cells or from the ventral VZ, from which many SVZ cells migrate dorsally (Marshall et al, 2003). Nothing is known about the mechanisms by which VZ cells transform into SVZ cells.…”

Section: Atf5 Negatively Regulates Neural Progenitor Differentiation mentioning

confidence: 99%

Downregulation of Activating Transcription Factor 5 Is Required for Differentiation of Neural Progenitor Cells into Astrocytes

Angelastro¹,

Mason²,

Игнатова³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…However, in vivo evidence for this hypothetical "astrocytic stem cell" is lacking. For example, retroviral lineage analyses have characterized the generation of olfactory interneurons, cortical astrocytes, and oligodendrocytes from SVZ progenitors (Marshall et al, 2003;Zerlin et al, 2004;Luskin, 1993), but whether GFAP ϩ astroglial "ancestors" can generate these three lineages in the postnatal SVZ has not been established. Previously, exploration of the neurogenic potential of astroglial cells has been hindered by the inability to both identify these cells at defined periods of development and subsequently follow their long-term fate.…”

Section: Introductionmentioning

confidence: 99%

Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem CellsIn Vivo

et al. 2006

View full text Add to dashboard Cite

To identify the fates that astroglial cells can attain in the postnatal brain, we generated mice carrying an inducible Cre recombinase (Cre-ER T2 ) controlled by the human GFAP promoter (hGFAP). In mice carrying the GCE (hGFAP-Cre-ER T2 ) transgene, OHT (4-hydroxytamoxifen) injections induced Cre recombination in astroglial cells at postnatal day 5 and allowed us to permanently tag these cells with reporter genes. Three days after recombination, reporter-tagged cells were quiescent astroglial cells that expressed the stem cell marker LeX in the subventricular zone (SVZ) and dentate gyrus (DG). After 2-4 weeks, the tagged GFAP lineage included proliferating progenitors expressing the neuronal marker Dcx (Doublecortin) in the SVZ and the DG. After 4 weeks, the GFAP lineage generated mature neurons in the olfactory bulb (OB), DG, and, strikingly, also in the cerebral cortex. A major portion of all neurons in the DG and OB born at the end of the first postnatal week were generated from GFAP ϩ cells. In addition to neurons, mature oligodendrocytes and astrocytes populating the cerebral cortex and white matter were also the progeny of GFAP ϩ astroglial ancestors. Thus, genetic fate mapping of postnatal GFAP ϩ cells reveals that they seed the postnatal brain with neural progenitors/stem cells that in turn give rise to neural precursors and their mature neuronal and oligodendrocytic progeny in many CNS regions, including the cerebral cortex.

show abstract

“…In the developing telencephalon, the neuroepithelium gives rise to the subventricular zone (SVZ), a secondary proliferative layer of progenitors that simultaneously generates both neurons and glia (for review, see Marshall et al, 2003). The contemporaneous production of neurons and glia makes the SVZ a unique system in which to study the molecular mechanisms directing cell fate decisions.…”

Section: Introductionmentioning

confidence: 99%

Olig2 Directs Astrocyte and Oligodendrocyte Formation in Postnatal Subventricular Zone Cells

Marshall¹,

Novitch²,

Goldman³

2005

J. Neurosci.

232

217

View full text Add to dashboard Cite

The subventricular zone (SVZ) in the neonatal mammalian forebrain simultaneously generates olfactory interneurons, astrocytes, and oligodendrocytes. The molecular cues that enable SVZ progenitors to generate three distinct cell lineages without a temporal switching mechanism are not known. Here, we demonstrate that the basic helix-loop-helix transcription factor Olig2 plays a central role in this process. Olig2 is specifically expressed in gliogenic progenitors in the postnatal SVZ and by all glial lineages derived from this structure. By expressing normal and dominant-interfering forms of Olig2 in vivo, we show that Olig2 repressor function is both sufficient and necessary to prevent neuronal differentiation and to direct SVZ progenitors toward astrocytic and oligodendrocytic fates. Although Olig2 activity has been associated previously with motor neuron and oligodendrocyte development, our findings establish a previously unappreciated role for Olig2 in the development of astrocytes. Furthermore, these results indicate that Olig2 serves a critical role in pan-glial versus neuronal fate decisions in SVZ progenitors, making it the first intrinsic fate determinant shown to operate in the early postnatal SVZ.

show abstract

Gliogenic and neurogenic progenitors of the subventricular zone: Who are they, where did they come from, and where are they going?

Cited by 136 publications

References 107 publications

Downregulation of Activating Transcription Factor 5 Is Required for Differentiation of Neural Progenitor Cells into Astrocytes

Downregulation of Activating Transcription Factor 5 Is Required for Differentiation of Neural Progenitor Cells into Astrocytes

Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem CellsIn Vivo

Olig2 Directs Astrocyte and Oligodendrocyte Formation in Postnatal Subventricular Zone Cells

Contact Info

Product

Resources

About