Glioneuronal tumor with neuropil-like islands

Prayson, Richard A.; Abramovich, Caroline M.

doi:10.1053/hupa.2000.19433

Cited by 8 publications

(19 citation statements)

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“…These authors demonstrated p53 immunoexpression in 4/6 cases (66.66%) studied by them and found 1p/19q loss of heterozygosity (LOH) deletion in none. Prayson and Abramovich found up to 40% of the tumor cells to show a positive immunoreactivity for p53 9 . Kevyani et al.…”

Section: Discussionmentioning

confidence: 97%

Glioneuronal tumor with neuropil‐like islands: A new entity

Agarwal¹,

Suri²,

Rishi³

et al. 2009

Neuropathology

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Glioneuronal tumor with neuropil-like islands (GTNI) is a distinctive and rare tumor characterized by both glial and neuronal differentiation. However, unlike other mixed glioneuronal tumors, which are characterized by a favorable prognosis, this neoplasm has been found to be potentially aggressive. We report here a case arising in a 60-year old male patient who presented with seizures, forgetfulness and right-sided hemiparesis, due to a left frontal lobe tumor. Unlike most cases described in the literature, the present tumor was unique in its radiological appearance, which was cystic. On microscopic evaluation, the glial component was chiefly gemistocytic punctuated by neuropil-like islands. Strong nuclear immunolabeling of p53 and absence of 1p/19q deletion by fluorescence in situ hybridization assay were consistent with those in previous reports.

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Section: Discussionmentioning

confidence: 97%

Glioneuronal tumor with neuropil‐like islands: A new entity

Agarwal¹,

Suri²,

Rishi³

et al. 2009

Neuropathology

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“…Reported cases were located supratentorially [46], with the exception of one example situated in the cervicothoracic spinal cord [12]. As a rule, the underlying lesions were astrocytomas WHO grade II or III [39, 46]; one case was associated with ependymoma [10]. …”

Section: Glioneuronal Tumour With Neuropil-like Islandsmentioning

confidence: 99%

The 2007 WHO Classification of Tumours of the Central Nervous System

et al. 2007

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The fourth edition of the World Health Organization (WHO) classiWcation of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a diVerent age distribution, location, genetic proWle or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic proWles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO 'Blue Book', the classiWcation is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classiWcation is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the deWnition of brain tumours to the clinical oncology and cancer research communities world-wide. Introduction and historical annotation

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“…While cases of cerebral GTNI are reported in the literature, 5–8 spinal GTNI are extremely rare and to the best of our knowledge only three case have been described so far 9–11 . We report herein a unique case of pediatric primary spinal cord GTNI with meningeal dissemination.…”

Section: Introductionmentioning

confidence: 83%

“…Rosette‐forming glioneuronal tumors (RGNT) represent a peculiar variant of GNT occurring infratentorially in the fourth ventricle with unusual clinico‐pathological features 2,3 and have been described as an independent entity in the current 2007 World Health Organization (WHO) classification of CNS neoplasms 4 . A distinctive form of glioneuronal tumor with neuropil‐like islands (GTNI) occurring in the cerebrum have been reported in the literature 5,6 . These tumors are composed of small round neurocytic cells immunoreactive to a wide range of neuronal markers, including the neuronal nuclear antigens HuC/D and NeuN, forming large rosette‐like structures around neuropil islands and dispersed in a glial fibrillary background.…”

Section: Introductionmentioning

confidence: 99%

Spinal glioneuronal tumor with neuropil‐like islands and meningeal dissemination: histopathological and radiological study of a pediatric case

Poliani

Sperlì

Valentini³

et al. 2009

Neuropathology

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Cerebral and spinal location of glioneuronal tumors have been recently described as a novel type of primary CNS neoplasia. A distinctive rare form of glioneuronal tumors with neuropil-like islands (GTNI) have been reported to occur in the adult cerebrum, whereas spinal GTNI localization is extremely rare. In the present report we describe a case of a 15-month-old child with a spinal GTNI of the cervical region and meningeal dissemination. Histologically the tumor was composed of round, small neurocytic-like cells arranged around eosinophilic neuropil cores and embedded in a diffuse fibrillar glial component forming prominent "rosetted" neuropil islands displaying strong immunoreactivity for neuronal markers. Cerebral GTNI shows abundant glial components not rarely exhibiting anaplastic features that justify their inclusion within the group of diffuse astrocytomas. In contrast, including our case, spinal GTNI do not show histological evidence of anaplastic features and exhibits a significant neuronal component that may imply considering these lesions in a separate group. Nevertheless, due to their exceptional rarity, the natural history of these lesions is not yet fully understood, but spinal GTNI seems to have an unfavorable clinical course despite their benign histopathological features, which must be taken into account for appropriate treatment and follow-up of the patient.

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Glioneuronal tumor with neuropil-like islands

Cited by 8 publications

References 0 publications

Glioneuronal tumor with neuropil‐like islands: A new entity

Glioneuronal tumor with neuropil‐like islands: A new entity

The 2007 WHO Classification of Tumours of the Central Nervous System

Spinal glioneuronal tumor with neuropil‐like islands and meningeal dissemination: histopathological and radiological study of a pediatric case

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