2017
DOI: 10.1073/pnas.1708433114
|View full text |Cite
|
Sign up to set email alerts
|

Global analysis of ribosome-associated noncoding RNAs unveils new modes of translational regulation

Abstract: SignificanceNoncoding RNAs are an underexplored reservoir of regulatory molecules in eukaryotes. We analyzed the environmental response of roots to phosphorus (Pi) nutrition to understand how a change in availability of an essential element is managed. Pi availability influenced translational regulation mediated by small upstream ORFs on protein-coding mRNAs. Discovery, classification, and evaluation of long noncoding RNAs (lncRNAs) associated with translating ribosomes uncovered diverse new examples of transl… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

13
196
2
9

Year Published

2017
2017
2024
2024

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 184 publications
(220 citation statements)
references
References 98 publications
(132 reference statements)
13
196
2
9
Order By: Relevance
“…The position of ribosome footprints generated from MBPs suggests that ribosome occupancy contributes to defining the site of phasiRNA biogenesis on these transcripts . Indeed, functional translation of a positionally conserved short ORF of the AtTAS3 transcript is critical to efficient tasiRNA production (Bazin et al, 2017).…”
Section: Xrn4-mediated Cotranslational Decaymentioning
confidence: 99%
“…The position of ribosome footprints generated from MBPs suggests that ribosome occupancy contributes to defining the site of phasiRNA biogenesis on these transcripts . Indeed, functional translation of a positionally conserved short ORF of the AtTAS3 transcript is critical to efficient tasiRNA production (Bazin et al, 2017).…”
Section: Xrn4-mediated Cotranslational Decaymentioning
confidence: 99%
“…Several well-characterized examples and global analyses indicate that uORFs can modulate the translation of their downstream main ORFs (12, 13, 1517). Moreover, numerous presumed non-coding RNAs have been found to possess translated small ORFs (sORFs), usually below 100 codons (7, 11, 18, 19). The protein products of these sORFs are so small that they may serve as signaling peptides (16, 19).…”
Section: Introductionmentioning
confidence: 99%
“…In plant research, ribosome profiling has been used to study the translational regulation in diverse aspects of plant physiology, for example, photomorphogenesis, chloroplast differentiation, cotyledon development, hypoxia, hormone responses, nutrient deprivation, drought, pathogen responses, and biogenesis of small interfering RNAs (15, 18, 2229). We previously optimized the resolution of this technique, specifically to 3-nt periodicity, to uncover unannotated ORFs in Arabidopsis (11).…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have shown that the mature, functional cucurbit SE‐CC contains the machinery for mRNA translation (Lin et al ; Ma et al ), and hence, it is possible that protein synthesis may occur in the phloem (Ham and Lucas ). In this situation, lncRNAs could act as regulators of translation (Jabnoune et al ; Bazin et al ), or be translated into short peptides (Ruizorera et al ) in the phloem. Furthermore, as SEs retain the endoplasmic reticulum (ER), miRNAs might inhibit the translation of target mRNAs at the SE‐ER (Li et al ).…”
Section: Discussionmentioning
confidence: 99%