Today, the sustainability challenge has become a relevant issue in the fashion industry. However, given that the request for sustainability is relatively new in this industry, empirical research that could guide companies towards supply chain sustainability is lacking. This study aims to deepen the understanding of the main strategic approaches to sustainability used in fashion supply chain management (SCM). Ten case studies were examined in terms of the practices that characterise these approaches. Moreover, contextual factors, drivers and barriers that support or hinder different approaches were identified. To accomplish this goal, both environmental sustainability and social sustainability were investigated, and all the areas of fashion SCM (i.e. new product development, source, make, deliver, retail, return, governance) were considered simultaneously to offer a wide overview of this industry's sustainability issue.