Global Consensus Position Statement on the use of Testosterone Therapy for Women

Davis, Susan R.; Baber, Rodney J; Panay, Nicholas; Bitzer, Johannes; Pérez, Sonia Cerdas; Islam, Rakibul M; Kaunitz, Andrew M.; Kingsberg, Sheryl A.; Lambrinoudaki, Ιrene; Liu, James H.; Parish, Sharon J.; Pinkerton, JoAnn V.; Rymer, Janice; Simon, James A.; Vignozzi, Linda; Wierman, Margaret E.

doi:10.1016/j.maturitas.2019.07.001

Cited by 30 publications

(95 citation statements)

References 16 publications

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“…Mean testosterone levels did not change over the study period and were unrelated to either age or menopause, perhaps due to the limited age range in the study (46-62 years) [15]. Testosterone levels have been noted by others to be maintained after age 65 as well [16].…”

Section: Womenmentioning

confidence: 65%

“…Although CVD outcomes per se were not assessed, a small randomized controlled trial in elderly women with heart failure found that 6 months of testosterone treatment was safe and effective for improving functional capacity, insulin resistance, and muscle strength [37]. Nonetheless, the only evidence-based indication for testosterone therapy for women is for the treatment of hypoactive sexual desire disorder (HSDD); there is insufficient evidence to support the use of testosterone for the treatment or prevention of any other symptom or clinical condition [16].…”

Section: Womenmentioning

confidence: 99%

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Sex differences in vascular aging in response to testosterone

2020

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Large elastic arterial stiffening and endothelial dysfunction are phenotypic characteristics of vascular aging, a major risk factor for age-associated cardiovascular diseases. Compared to men, vascular aging in women appears to be slowed until menopause, whereafter vascular aging accelerates to match that seen in men. These sex differences in vascular aging have been attributed to changes in sex hormones that occur with aging. Although the role of estradiol in vascular aging in women has been highlighted in recent aging research, little is known about the impact of declining testosterone concentrations in both sexes. Importantly, while androgen concentrations generally decline with age in men, there are data that indicate reductions in androgen concentrations in women as well. Evidence suggests that low testosterone is associated with impaired endothelial function and increased arterial stiffness in men, although the effect of androgens on vascular aging in women remains unclear. Testosterone may modulate vascular aging by mitigating the effects of oxidative stress and inflammation, although there is sex specificity to this effect. The purpose of this review is to present and summarize the research regarding sex differences in vascular aging in response to androgens, specifically testosterone. Because exercise is a potent lifestyle factor for slowing and reversing vascular aging, we briefly summarize the available literature regarding the regulatory function of testosterone on vascular adaptations to exercise training.

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Section: Womenmentioning

confidence: 65%

Section: Womenmentioning

confidence: 99%

Sex differences in vascular aging in response to testosterone

2020

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“…In this setting, there is greater potential for treatment to result in supraphysiological testosterone levels. The position statement suggests that ‘‘where approved female preparations are unavailable, off‐label prescribing of an approved male formulation is reasonable” 1 . Bio‐identical and compounded products are not recommended.…”

Section: Australian Perspectivementioning

confidence: 99%

“…The 2019 global consensus position statement on the use of testosterone therapy for women 1 aims to provide guidance for clinicians managing women with female sexual dysfunction. The recommendations, graded according to levels of evidence, have been developed by an international taskforce with representatives from a range of organisations and societies, headed by Australian endocrinologist Professor Susan Davis, the current President of the International Menopause Society.…”

mentioning

confidence: 99%

“…The authors of the position statement comment that the relationship between endogenous androgen concentrations and sexual function remains uncertain because of issues related to androgen assays in some studies. Notwithstanding these factors, it is recommended that a baseline measurement of testosterone be taken to avoid overtreatment 1 . Serum total testosterone rather than free testosterone is the recommended biomarker.…”

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confidence: 99%

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