Global Consensus Position Statement on the Use of Testosterone Therapy for Women

Davis, Susan Ruth; Baber, Rodney J; Panay, Nicholas; Bitzer, Johannes; Pérez, Sonia Cerdas; Islam, Rakibul M; Kaunitz, Andrew M.; Kingsberg, Sheryl A.; Lambrinoudaki, Ιrene; Liu, James H.; Parish, Sharon J.; Pinkerton, Jo Ann V.; Rymer, Janice; Simon, James A.; Vignozzi, Linda; Wierman, Margaret E.

doi:10.1210/jc.2019-01603

Cited by 184 publications

(116 citation statements)

References 16 publications

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“…According to the recent consensus referring to testosterone therapy for women (2019) the only evidence-based indication for the use of testosterone in women is for the treatment of postmenopausal women who have been diagnosed as having HSDD after formal bio-psychosocial assessment [ 52 ]. Patients should be monitored for their clinical response to treatment and assessed for signs of androgen excess with a serum total T concentration every 6 months, to screen for overuse.…”

Section: Discussionmentioning

confidence: 99%

“…If no benefit is experienced by this time, treatment should be ceased. Systemic DHEA is not associated with significant improvement in libido or sexual function in postmenopausal women with normal adrenal function and cannot be recommended for women with HSDD [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…There is not sufficient data confirming the efficacy of such treatment for other indications. HSDD diagnosis must be deliberated, based on excluding other factors which may lead to sexual disorders in that women population [ 52 ].…”

Section: Androgens In Menopausementioning

confidence: 99%

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Changes of androgens levels in menopausal women

Brzozowska

Lewiński²

2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Changes of androgens levels in menopausal women

Brzozowska

Lewiński²

2020

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“…The choice of the right progestin is critical as it can make the difference in long-term outcomes [219]. Lastly, there is an unmet need for providing and approving testosterone treatments specific for women, formulated with the aim of approximating physiological testosterone concentrations for premenopausal women [220]. Nowadays just a few studies have evaluated the musculoskeletal effects of testosterone.…”

Section: Sex Disparity In Osteoporosis Risk and Preventionmentioning

confidence: 99%

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

Gemmati

Varani

Bramanti

et al. 2019

IJMS

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Gender medicine is the first step of personalized medicine and patient-centred care, an essential development to achieve the standard goal of a holistic approach to patients and diseases. By addressing the interrelation and integration of biological markers (i.e., sex) with indicators of psychological/cultural behaviour (i.e., gender), gender medicine represents the crucial assumption for achieving the personalized health-care required in the third millennium. However, ‘sex’ and ‘gender’ are often misused as synonyms, leading to frequent misunderstandings in those who are not deeply involved in the field. Overall, we have to face the evidence that biological, genetic, epigenetic, psycho-social, cultural, and environmental factors mutually interact in defining sex/gender differences, and at the same time in establishing potential unwanted sex/gender disparities. Prioritizing the role of sex/gender in physiological and pathological processes is crucial in terms of efficient prevention, clinical signs’ identification, prognosis definition, and therapy optimization. In this regard, the omics-approach has become a powerful tool to identify sex/gender-specific disease markers, with potential benefits also in terms of socio-psychological wellbeing for each individual, and cost-effectiveness for National Healthcare systems. “Being a male or being a female” is indeed important from a health point of view and it is no longer possible to avoid “sex and gender lens” when approaching patients. Accordingly, personalized healthcare must be based on evidence from targeted research studies aimed at understanding how sex and gender influence health across the entire life span. The rapid development of genetic tools in the molecular medicine approaches and their impact in healthcare is an example of highly specialized applications that have moved from specialists to primary care providers (e.g., pharmacogenetic and pharmacogenomic applications in routine medical practice). Gender medicine needs to follow the same path and become an established medical approach. To face the genetic, molecular and pharmacological bases of the existing sex/gender gap by means of omics approaches will pave the way to the discovery and identification of novel drug-targets/therapeutic protocols, personalized laboratory tests and diagnostic procedures (sex/gender-omics). In this scenario, the aim of the present review is not to simply resume the state-of-the-art in the field, rather an opportunity to gain insights into gender medicine, spanning from molecular up to social and psychological stances. The description and critical discussion of some key selected multidisciplinary topics considered as paradigmatic of sex/gender differences and sex/gender inequalities will allow to draft and design strategies useful to fill the existing gap and move forward.

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“…A new interesting avenue of research, which may provide interesting data for the endocrinologist treating female SD, is the transdermal and topical use of testosterone. A position statement issued in 2019 by several societies studying female sexual health, among which the International Menopause Society, the Endocrine Society, the International Society for Sexual Medicine, and the International Society of Endocrinology, clearly states that treatment of HSDD is the only evidence-based indication for testosterone therapy in post-menopausal women (85). The hormone was indeed approved as patches of 300 µg for the HSSD in women with precocious menopause (86).…”

Section: Testosterone Deficiencymentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist

Carosa

Sansone

Jannini

2020

European Journal of Endocrinology

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Sexual function is an important component of either general health and quality of life in both genders. Many studies have focused on the different risk factors for sexual dysfunctions, proving an association with several medical conditions. Endocrine disorders have been often mentioned in the pathogenesis of female and male sexual dysfunctions; however, particularly in women, sexual function is rarely addressed during clinical, in general, and endocrinological, in particular, consultations. As a thorough diagnosis is required in order to provide an adequately tailored treatment, knowing how each endocrine dysfunction can impair sexual health is of the utmost importance, considering the high prevalence of conditions such as disorders of pituitary, thyroid, adrenal, gonads, as well as metabolic disorders. We performed a thorough review of existing literature on the different mechanisms involved in the pathogenesis of female sexual dysfunctions secondary to endocrine disorders in order to provide an up-to-date reference.

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Global Consensus Position Statement on the Use of Testosterone Therapy for Women

Cited by 184 publications

References 16 publications

Changes of androgens levels in menopausal women

Changes of androgens levels in menopausal women

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

MANAGEMENT OF ENDOCRINE DISEASE: Female sexual dysfunction for the endocrinologist

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