Global DNA hypomethylation and DNA hypermethylation of the alpha synuclein promoter in females with anorexia nervosa

Frieling, Helge; Gozner, Andreas; Römer, K.; Lenz, Bernd; Bönsch, Dominikus; Wilhelm, Júlia; Hillemacher, Thomas; Zwaan, Martina de; Kornhuber, Johannes; Bleich, Stefan

doi:10.1038/sj.mp.4001931

Cited by 97 publications

(81 citation statements)

References 8 publications

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“…The potential to identify distinct epigenetic biomarkers associated with eating disorders has also been explored (74,75). Disruption of epigenetic profile is also implicated in some adverse health outcomes for subjects conceived by means of assisted reproductive technologies (76).…”

Section: Epigenetics and Diseasementioning

confidence: 99%

Prospects for Epigenetic Epidemiology

Foley¹,

Craig²,

Morley³

et al. 2008

American Journal of Epidemiology

220

162

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Section: Epigenetics and Diseasementioning

confidence: 99%

Prospects for Epigenetic Epidemiology

Foley¹,

Craig²,

Morley³

et al. 2008

American Journal of Epidemiology

220

162

View full text Add to dashboard Cite

“…[20][21][22] Indeed, patients with acute AN were reported to have a reduced global DNA methylation. 23 In a recent pilot study 24 we investigated promoter-specific DNA methylation and mRNA expression of the prohormone POMC in patients with and without AN. POMC is prone to epigenetic regulation owing to promoter-related DNA methylation.…”

Section: Discussionmentioning

confidence: 99%

Smoking, but Not Malnutrition, Influences Promoter-Specific DNA Methylation of the Proopiomelanocortin Gene in Patients with and without Anorexia Nervosa

Ehrlich

Walton²,

Roffman

et al. 2012

Can J Psychiatry

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Objective: Our pilot study evaluates the impact of environmental factors, such as nutrition and smoking status, on epigenetic patterns in a disease-associated gene. Method:We measured the effects of malnutrition and cigarette smoking on proopiomelanocortin (POMC) promoter-specific DNA methylation in female patients with and without anorexia nervosa (AN). POMC and its derived peptides (alpha melanocyte stimulating hormone and adrenocorticotropic hormone) are implicated in stress and feeding response. Promoter-specific DNA methylation of the POMC gene was determined in peripheral blood mononuclear cells of 54 healthy female control subjects, 40 underweight patients with AN, and 21 weight-restored patients with AN using bisulfite sequencing. Malnutrition was characterized by plasma leptin.Results: POMC promoter-specific DNA methylation was not affected by diagnosis or nutritional status but significantly negatively associated with cigarette smoking. Conclusions:Although malnutrition may be expected to reduce DNA methylation through its effects on one-carbon metabolism, our negative results are in line with several in vitro and clinical studies that did not show a direct relation between gene-specific DNA methylation and folate levels. In contrast, smoking has been repeatedly reported to alter DNA methylation of specific genes and should be controlled for in future epigenetic studies. W W WObjectif : Notre étude pilote évalue l'effet des facteurs environnementaux, comme la nutrition et le statut de fumeur, sur les modèles épigénétiques d'un gène associé à la maladie.Méthode : Nous avons mesuré les effets de la malnutrition et du tabagisme sur la méthylation de l'ADN spécifique au promoteur du gène pro-opiomélanocortin (POMC) chez des patientes avec et sans anorexie mentale (AM). Le POMC et ses peptides dérivés (hormone mélanostimulante alpha et hormone adrénocorticotrope) sont impliqués dans la

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“…A differential methylation pattern of additional genes apart from SNCA, such as ARK16, GPNMB, and STX1B, has been reported in PD [26], although their mechanistic link to PD has yet to be established. Interestingly, studies in anorexia patients and alcoholics have also reported hypermethylation of the SNCA locus [27,28]. However, epidemiological evidence linking such obsessive behaviors to PD pathogenesis is still lacking.…”

Section: Epigenetic Modulation In Familial Parkinson's Diseasementioning

confidence: 99%