Global gene-mining strategy for searching nonribosomal peptides as antimicrobial agents from microbial sources

Han, Panpan; Ma, Aijin; Ning, Yuping; Zhou, C.; Liu, Yangliu; Liu, Zhuo; Li, Siting; Jia, Yingmin

doi:10.1016/j.lwt.2023.114708

Cited by 1 publication

(3 citation statements)

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“…Bogorols, Brevibacillins, Brevilaterins, and BT peptides have similar basic structures. They contain 13 amino acids and an N-terminal C6-fa y acid chain (Hmp-Aba-Val-Orn-Val-Val-Val-Lys-Val-Leu-Lys-Tyr-Leu-Vol) [63], with a molecular weight of 1.555-1.617 kDa, with amino acid substitutions at some positions. Therefore, these similar AMPs should be named Brevilaterins, as shown in Figure 1 [10,26,[64][65][66][67].…”

Section: Structural Features Of Brevilaterinsmentioning

confidence: 99%

“…B. laterosporus produces a variety of AMPs and is thought to be responsible for producing short-sequence (<20 AAs) AMPs [ 10 , 62 ]. Seventeen AMPs produced by B. laterosporus have been identified, but the nomenclature varies among discoverers [ 63 ], including Bogorols [ 64 ], Brevibacillins [ 65 , 66 ], Brevilaterins [ 10 ], BT peptides [ 67 ], BL-A60 [ 25 ], Bacteriocin DS-3 [ 68 ], and others. Bogorols, Brevibacillins, Brevilaterins, and BT peptides have similar basic structures.…”

Section: B Laterosporus Antimicrobial Peptidesmentioning

confidence: 99%

“… Structural characteristics of Brevilaterins [ 10 , 26 , 64 , 65 , 66 , 67 ]. This structure diagram has been drawn based on information regarding the structure and visual representation provided in reference [ 63 , 64 ]. In the same amino acid sequence template, the structures of these antimicrobial peptides differ only at the amino acids at specific positions, and the corresponding substituted amino acids are indicated by different colored ovals.…”

Section: Figurementioning

confidence: 99%

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Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Liu,

Zai,

Weng

et al. 2024

Microorganisms

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Brevibacillus laterosporus (B. laterosporus) is widely distributed in nature and demonstrates significant potential for applications in biological control, environmental protection, agricultural production, and clinical medicine. This review provides a comprehensive overview of the applications of B. laterosporus in crop cultivation and animal feeding, as well as an examination of the antimicrobial peptides produced by B. laterosporus and their antibacterial mechanisms. B. laterosporus enhances crop cultivation by secreting hydrolases to improve nutrient absorption capabilities, synthesizing hormones to promote crop growth, and producing proteins to inhibit the reproduction of harmful organisms. B. laterosporus has been used to improve animal production by regulating the structure of the intestinal microbiota and inhibiting the growth of pathogenic bacteria through the secretion of various antimicrobial peptides. The bactericidal activity of Brevilaterins secreted by B. laterosporus is attributed to their ability to bind to lipopolysaccharide/lipid II molecules on the cell membrane, thereby altering permeability. Brevilaterins also inhibit bacterial reproduction by affecting relevant gene pathways in the cell membranes of pathogenic bacteria. These pathways include ATP synthesis, peptidoglycan biosynthesis, membrane transport, and cellular metabolism. In conclusion, B. laterosporus exhibits substantial potential as a probiotic activity in crop and animal production. However, applications of B. laterosporus in animal production could be improved, necessitating further research to elucidate the underlying probiotic mechanisms.

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