Global Issues in Volatile Substance Misuse

Dell, Colleen Anne; Gust, Steven W.; MacLean, Sarah

doi:10.3109/10826084.2011.580169

Cited by 56 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In other populations, inhalants have been linked to cognitive and neurological impairment, sudden sniffing death syndrome due to cardiac arrhythmia, renal, pulmonary and teratogenic effects [58,66,68]. Additionally, evidence exists of psychological and physical dependence among volatile solvent users [30,69].…”

Section: Discussionmentioning

confidence: 99%

The epidemiology of substance use among street children in resource‐constrained settings: a systematic review and meta‐analysis

et al. 2013

View full text Add to dashboard Cite

Aims To compile and analyze critically the literature published on street children and substance use in resource-constrained settings. Methods We searched the literature systematically and used meta-analytical procedures to synthesize literature that met the review’s inclusion criteria. Pooled-prevalence estimates and 95% confidence intervals (CI) were calculated using the random-effects model for life-time substance use by geographical region as well as by type of substance used. Results Fifty studies from 22 countries were included into the review. Meta-analysis of combined life-time substance use from 27 studies yielded an overall drug use pooled-prevalence estimate of 60% (95% CI = 51–69%). Studies from 14 countries contributed to an overall pooled prevalence for street children’s reported inhalant use of 47% (95% CI = 36–58%). This review reveals significant gaps in the literature, including a dearth of data on physical and mental health outcomes, HIV and mortality in association with street children’s substance use. Conclusions Street children from resource-constrained settings reported high life-time substance use. Inhalants are the predominant substances used, followed by tobacco, alcohol and marijuana.

show abstract

Section: Discussionmentioning

confidence: 99%

The epidemiology of substance use among street children in resource‐constrained settings: a systematic review and meta‐analysis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…This conclusion is also supported by one of our previous studies that demonstrated that d -serine, also a selective co-agonist at the glycine binding site of NMDA receptors, reversed locomotor hyperactivity, motor incoordination, and learning impairment induced by toluene administration in rats (Lo et al , 2009). Indeed, the neurobehavioral profiles of toluene including biphasic effect on locomotor activity (Riegel and French, 1999; Riegel et al , 2003; Chan et al , 2004; Dell et al , 2011), ataxia (Lo et al , 2009), and learning impairments (Lo et al , 2009; Win-Shwe et al , 2010; Huerta-Rivas et al , 2012) overlap those of NMDA receptor antagonists, such as phencyclidine (PCP) and ketamine. Sarcosine and another GlyT1 inhibitor, N -(3-[4’-fluorophenyl]-3-[4’-phenylphenoxy]propyl)sarcosine (NFPS), have been reported to antagonize the effects of NMDA receptor channel blockers.…”

Section: Discussionmentioning

confidence: 99%

Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice

Chan

Chung

Stoker

et al. 2012

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances, including motor incoordination and cognitive impairment. Toluene alters the function of a large number of receptors and ion channels. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in toluene-induced behavioral manifestations. The present study determined the effects of various toluene doses on motor coordination, recognition memory, body temperature, and intracranial self-stimulation (ICSS) thresholds in mice. Additionally, the effects of sarcosine on the behavioral and physiological effects induced by toluene were evaluated. Sarcosine may reverse toluene-induced behavioral manifestations by acting as an NMDA receptor co-agonist and inhibiting the effects of the type I glycine transporter (GlyT1). Mice were treated with toluene alone or combined with sarcosine pretreatment and assessed for rotarod performance, object recognition memory, rectal temperature, and ICSS thresholds. Toluene dose-dependently induced motor incoordination, recognition memory impairment, and hypothermia and lowered ICSS thresholds. Sarcosine pretreatment reversed toluene-induced changes in rotarod performance, novel object recognition, and rectal temperature but not ICSS thresholds. These findings suggest that the sarcosine-induced potentiation of NMDA receptors may reverse motor incoordination, memory impairment, and hypothermia but not the enhancement of brain stimulation reward function associated with toluene exposure. Sarcosine may be a promising compound to prevent acute toluene intoxications by occupational or intentional exposure.

show abstract

“…Volatile substance abuse is a dangerous behavior that has been documented throughout the world [13,43]. Within just the United States, a recent National Survey on Drug Use and Health estimates that more than 22 million Americans twelve years of age and older have abused volatile substances at least once in their lifetimes [48].…”

Section: Introductionmentioning

confidence: 99%

Binge toluene exposure in pregnancy and pre-weaning developmental consequences in rats

Bowen

Hannigan

2013

Neurotoxicology and Teratology

View full text Add to dashboard Cite

The persistent rate of abuse of inhaled organic solvents, especially among women of child-bearing age, raises the risk for teratogenic effects of maternal toluene abuse. In this study, timed-pregnant Sprague Dawley rats were exposed from Gestation Day (GD) 8 to GD20 to 12,000 or 8,000 parts per million (ppm) toluene, or 0 ppm (controls) for 30 min twice daily, 60 min total daily exposure. Pups were assessed from postnatal day (PN) 4 to PN21 using a developmental battery measuring growth (i.e., body weight), maturational milestones (e.g., eye opening & incisor eruption), and biobehavioral development (e.g., negative geotaxis & surface righting). Pups exposed in utero to 12,000 ppm or 8,000 ppm toluene weighed significantly less than the non-exposed control pups beginning at PN4 and PN12 (respectively) until PN21. Toluene resulted in significant increases in an index of poor perinatal outcome, specifically a composite of malformations, defined “runting” and neonatal death. No significant delays were observed in reaching maturational milestones. The results reveal that brief, repeated, prenatal exposure to high concentrations of toluene can cause growth retardation and malformations in rats. A comparison of the present, conservative results with findings in previous studies implies that binge patterns of toluene exposure in pregnant rats modeling human solvent abuse can result in developmental and morphological deficits in offspring. These results do not exclude the possibility that maternal toxicity as well as teratogenic effects of toluene may contribute to outcomes. The results suggest that abuse of inhaled organic solvents like toluene may result in similar early developmental outcomes in humans.

show abstract

Global Issues in Volatile Substance Misuse

Cited by 56 publications

References 16 publications

The epidemiology of substance use among street children in resource‐constrained settings: a systematic review and meta‐analysis

The epidemiology of substance use among street children in resource‐constrained settings: a systematic review and meta‐analysis

Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice

Binge toluene exposure in pregnancy and pre-weaning developmental consequences in rats

Contact Info

Product

Resources

About