Global Longitudinal Strain and Left Atrial Volume Index Provide Incremental Prognostic Value in Patients With Hypertrophic Cardiomyopathy

Hiemstra, Yasmine L.; Debonnaire, Philippe; Bootsma, Marianne; Zwet, Erik W. van; Delgado, Victoria; Schalij, Martin J.; Atsma, Douwe E.; Bax, Jeroen J.; Marsan, Nina Ajmone

doi:10.1161/circimaging.116.005706

Cited by 74 publications

(54 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GLS was also a marker of ventricular arrhythmias [39] and was independently associated with adverse cardiovascular outcomes in HCM [69]. A recent study concluded that a reduction of GLS À15% represented patients with better survival in HCM and suggested that GLS should be considered a valuable subclinical biomarker to be incorporated in the standardised risk stratification workup of HCM patients [70].…”

Section: Hypertrophic Cardiomyopathiesmentioning

confidence: 99%

Echocardiographic Strain in Clinical Practice

Trivedi

Altman

Stanton

et al. 2019

Heart, Lung and Circulation

View full text Add to dashboard Cite

The accurate evaluation of left ventricular (LV) function has been central to monitoring of therapy, institution of specific therapeutic interventions and as a prognostic marker for risk stratification in a variety of cardiovascular conditions. However, LV ejection fraction, the most commonly used measure of LV systolic function, is a 'coarse' measure of global LV function, with several limitations. Strain analysis, a measure of myocardial deformation, has come to the forefront more recently as a more sensitive measure of myocardial function than LV ejection fraction. Its utility in detection of early subclinical LV dysfunction, defining regional variation in specific cardiomyopathies, utility to monitor improvement with therapy and as a prognostic marker in a variety of cardiac conditions has led to its increasing use in clinical practice. This review will briefly summarise specific methodological aspects, use in diagnosis and prognostic utility of strain analysis in various cardiovascular conditions.

show abstract

Section: Hypertrophic Cardiomyopathiesmentioning

confidence: 99%

Echocardiographic Strain in Clinical Practice

Trivedi

Altman

Stanton

et al. 2019

Heart, Lung and Circulation

View full text Add to dashboard Cite

show abstract

“…Left ventricular function abnormalities, even without overt structural changes in the heart, can be a marker of sudden death. Larger left atrial volume index, longer mechanical dispersion indices, and decreased global longitudinal peak strain are markers for appropriate implantable defibrillator shocks in patients with HCM . Lower values of 2D speckle tracking‐derived end‐systolic peak longitudinal strain is described as a predictor of nonsustained ventricular tachycardia and SCD in patients with HCM .…”

Section: Functional Abnormalitiesmentioning

confidence: 99%

“…Larger left atrial volume index, longer mechanical dispersion indices, and decreased global longitudinal peak strain are markers for appropriate implantable defibrillator shocks in patients with HCM. 15,16 Lower values of 2D speckle tracking-derived end-systolic peak longitudinal strain is described as a predictor of nonsustained ventricular tachycardia and SCD in patients with HCM. 17 Advanced LV diastolic dysfunction like restrictive LV filling is a strong predictor of sudden death in HCM.…”

Section: Fun C Tional Ab Normalitie Smentioning

confidence: 99%

Value of echocardiogram in predicting sudden cardiac death: A look beyond ejection fraction

Koshy

George

2019

Echocardiography

View full text Add to dashboard Cite

“…Second, we were unable to obtain biochemical values or use another imaging method to correlate these associations with our findings and conduct a follow-up of these subjects to assess prognosis and cardiac complications. (10)(11)(12)(13) 12 (10-13) 10 (9-13) 10 (9-11.2) 0.010 E/e' 7.9 (6.5-9.9) 9.3 (7.9-11.9) 11.6 (9.7-14.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Left ventricular and atrial global strain evaluation within subtypes of ventricular remodeling

Zavaleta

Villa²,

Diaz

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Left ventricular hypertrophy is associated with poor prognosis and adverse events. Left ventricular and left atrial global strain and left atrial reservoir strain (LV-GS; LAGS ; LA-RS) could be used as markers for myocardial function in different forms of ventricular remodeling. The aim of this study was to evaluate LV-GS and LAGS scores in different ventricular remodeling variants and identify risk factors for myo-cardial dysfunction. Methods and Results: This cross-sectional study was divided into four groups of ventricular remodeling: normal geometry, eccentric hypertrophy (EH), concentric hypertrophy (CH) and concentric remodeling (CR). Strain analysis was obtained using standardized protocols. We included 121 subjects, 33 with previous myocardial infarction (MI). We found that EH had the lowest LV-GS and CH the lowest LAGS and LA-RS. Atrial and ventricular dysfunction was present in 40 (33%) and 14 (11.5%) subjects, respectively. Smoking, male sex and previous MI were associated with LV dysfunction and smoking and dyslipidemia with LA dysfunction. EH was closely associated with LV dysfunction and CH with LA dysfunction. Conclusions: We conclude that different types of ventricular geometry had echocardiographic profiles associated with different risk factors for dysfunction assessed by strain. The assessment of ventricular remodeling by global strain could be used as a complementary tool in the echocardiographic evaluation of ventricular and atrial function.

show abstract

Global Longitudinal Strain and Left Atrial Volume Index Provide Incremental Prognostic Value in Patients With Hypertrophic Cardiomyopathy

Abstract: GLS and LAVI are independently associated with adverse outcome in patients with hypertrophic cardiomyopathy and may help to optimize risk stratification in these patients.

Cited by 74 publications

References 34 publications

Echocardiographic Strain in Clinical Practice

Echocardiographic Strain in Clinical Practice

Value of echocardiogram in predicting sudden cardiac death: A look beyond ejection fraction

Left ventricular and atrial global strain evaluation within subtypes of ventricular remodeling

Contact Info

Product

Resources

About