Global methylation and promoter-specific methylation of the P16, SOCS-1, E-cadherin, P73 and SHP-1 genes and their expression in patients with multiple myeloma during active disease and remission

Martínez-Baños, Déborah; Sánchez-Hernández, Beatríz; Jiménez, Guadalupe; Barrera-Lumbreras, Georgina; Barrales-Benítez, Olga

doi:10.3892/etm.2017.4274

Cited by 19 publications

(13 citation statements)

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“…Genome-wide methylation arrays have been performed at several stages of MM disease, demonstrating the occurrence of DNA hypomethylation at early MM phases; importantly, the hypomethylated status was shown to further decline during MM progression [ 34 ]. Notably, promoter hypermethylation of several cancer-related genes (i.e., BNIP-3, p16, E-CAD, DAPK-1), was reported to correlated with adverse prognosis [ 30 , 128 , 129 , 130 ]. Recent studies have reported on the promoter methylation-dependent silencing of RASSF4 (RAS association domain family member 4), occurring with MM disease progression; with a correlation with adverse prognosis [ 131 ].…”

Section: Role Of Epigenetics In Supporting the Mgus-to-mm Transitimentioning

confidence: 99%

Epigenetic Aberrations in Multiple Myeloma

Caprio

Sacco

Giustini

et al. 2020

Cancers

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Multiple myeloma (MM) is a plasma cell dyscrasia characterized by proliferation of clonal plasma cells within the bone marrow. Several advances in defining key processes responsible for MM pathogenesis and disease progression have been made; and dysregulation of epigenetics, including DNA methylation and histone modification, has emerged as a crucial regulator of MM pathogenesis. In the present review article, we will focus on the role of epigenetic modifications within the specific context of MM.

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Section: Role Of Epigenetics In Supporting the Mgus-to-mm Transitimentioning

confidence: 99%

Epigenetic Aberrations in Multiple Myeloma

Caprio

Sacco

Giustini

et al. 2020

Cancers

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“…In addition, a high mutation rate in SOCS genes was observed in patients with ovarian cancer [16]. SOCS genes methylation may play important roles in carcinogenesis and tumor progression and may be used as diagnostic and prognostic tumor biomarkers [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Zhang¹,

Sun²,

Bao³

2021

Preprint

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Backgroud:Suppressors of cytokine signaling (SOCS) family play important roles in the development of cancers by inhibiting the transmission of the Janus kinases–signal transducers and activators of transcription (JAK-STAT) signaling pathway. However, the expression patterns and prognostic value of SOCS family genes in non-small cell lung cancer (NSCLC) remains unclear. Methods: The SOCS family genes expression profiles were explored using ONCOMINE and GEPIA online tools. The mutation and copy number alterations of SOCS family genes in NSCLC were assessed by cBioportal for Cancer Genomics. The methylation status of SOCS family members were analyzed through MEXPRESS and UCSC Xena website. The prognostic values of SOCS family genes in NSCLC were explored through Kaplan-Meier Plotter database. Results: The expression levels of SOCS2, SOCS3, and cytokine-inducible SH2-containing protein (CIS/CISH) were significantly reduced in NSCLC tissues compared to normal lung tissues. The aberrant DNA methylation of SOCS family genes were frequent in NSCLC. CISH methylation was negatively correlated with gene expression in NSCLC. The Kaplan-Meier Plotter analysis demonstrated high expression of SOCS1 may be a predictor of poor prognosis in lung adenocarcinoma(LUAD) but served as a favorable prognostic marker of lung squamous cell carcinoma. The high expression levels of SOCS2 and SOCS4-7 were significantly correlated with better overall survival (OS) in LUAD but not in lung squamous carcinoma (LUSC) patients. Conclusions:Our findings indicated that the aberrant gene expression and DNA methylation of SOCS family members are common in NSCLC and contribute to tumorigenesis. SOCS family genes may serve as therapeutic targets and prognostic biomarkers for NSCLC patients

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“…Besides, MGMT is tightly related to the prognosis of breast cancer, esophageal cancer, and glioma [39][40][41]; LCAT is veri ed to be markedly correlated with the prognosis of HCC, which has constituted a 4-gene signature with SPINK1, TXNRD1, and PZP [42]. Additionally, CISH is associated with the prognosis for patients with gallbladder carcinoma, breast cancer, prostate cancer, and multiple myeloma [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Using Integrated Multi-Omics Data Analysis to Identify 5-gene Signature for Predicting Survival of Patients with Hepatocellular Carcinoma

Zhang

Zhao

et al. 2021

Preprint

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Due to the poor prognosis for hepatocellular carcinoma (HCC) presently, a systemic analysis supported by the multi-omics data is extremely necessary to search for gene markers for the clinical prognostic prediction of HCC. The data on RNA-seq, single nucleotide polymorphism (SNP), and copy number variation (CNV), etc. were downloaded from TCGA, leading to a final of 367 samples, which were divided into training set and testing set randomly. In the training set, both prognosis-related genes and those with SNP or CNV were screened, which were incorporated for feature selection using the random forest method. The testing and GEO verification sets (N = 265) were used to verify the constructed gene-related prognosis model. qPCR was used to detect the expression of 5 genes in clinical specimens. After including genomic variant and prognosis-related genes, we got 78 candidate genes and 5 feature genes (CISH, LHPP, MGMT, PDRG1, and LCAT) eventually through random forest feature selection. The 5-gene signature is an independent prognostic risk factor for HCC patients. In addition, the signature shows good predicting performance and clinical practicality in train- ing set, testing set and external verification set. The results of qPCR based on clinical samples showed that the expression of PDRG1 was increased in colon cancer tissues and the expression of CISH, LHPP, MGMT and LCAT were decreased in colon cancer tissues. We identify the ability of 5-gene signature to serve as an innovative marker of survival prediction for patients with HCC.

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Global methylation and promoter-specific methylation of the P16, SOCS-1, E-cadherin, P73 and SHP-1 genes and their expression in patients with multiple myeloma during active disease and remission

Abstract: Abstract. Tumor suppressor gene promoter CpG island methylation is a well-recognized mechanism in cancer pathogenesis, but its role in multiple myeloma (MM) is controversial. The present study investigated the methylation status and expression of

Cited by 19 publications

References 50 publications

Epigenetic Aberrations in Multiple Myeloma

Epigenetic Aberrations in Multiple Myeloma

Expression Status and Prognostic Values of SOCS Family Genes in Non-small Cell Lung Cancer

Using Integrated Multi-Omics Data Analysis to Identify 5-gene Signature for Predicting Survival of Patients with Hepatocellular Carcinoma

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