Global myocardial perfusion and diastolic function are impaired to a similar extent in patients with type 2 diabetes mellitus and in patients with coronary artery disease—evaluation by contrast echocardiography and pulsed tissue Doppler

Abstract

Aims/hypothesis Using modern echocardiography, we quantified the extent of global myocardial function and

Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease

“…The mean baseline value E' of 8.2+1.5 cm/second diastolic myocardial velocity in the present data is consistent with earlier data showing values of 8.8+1.7 cm/second in individuals with type 2 diabetes without coronary artery disease vs. 10.1+1.7 in age matched non-diabetic controls, 30 and similar also to an analogue study with values of 8.5+1.7 vs. 9.5+1.7 cm/second. 22 The rosiglitazone-induced augmentation of diastolic myocardial velocity to 8.9+1.2 cm/second observed here does not bring diastolic function to the levels of non-diabetic controls, however.…”

Structural lesions and changing pattern of expression of genes encoding cardiac muscle proteins are associated with ventricular myocyte dysfunction in type 2 diabetic Goto-Kakizaki rats fed a high-fat diet

“…A variety of diastolic and systolic dysfunctions have been widely reported in type 2 diabetic patients, and the severity of abnormalities depends on the patients' age and the duration of diabetes. Haemodynamic abnormalities include reduced left ventricular ejection fraction, impaired myocardial velocity at early diastole, abnormal relaxation during the early filling phase, prolonged isovolumetric relaxation, lower peak systolic and early diastolic velocity, impaired diastolic relaxation and filling and reduced peak filling rate (von Bibra et al 2005;Dounis et al 2006;Markuszewski et al 2006;Sharman et al 2007). The GotoKakizaki (GK) rat is a genetic animal model of type 2 diabetes, which was created by selective breeding of an outbred colony of Wistar rats with selection for high…”

Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+signalling in young type 2 Zucker diabetic fatty rat heart

“…Clinical and preclinical studies using Doppler imaging, echocardiography, radionuclide angiography and other techniques have demonstrated a variety of diastolic and systolic dysfunctions in type 2 diabetic patients. These haemodynamic abnormalities include reduced left ventricular ejection fraction, impaired myocardial velocity at early diastole, abnormal relaxation during the early filling phase, prolonged isovolumetric relaxation, lower peak systolic and early diastolic velocity, impaired diastolic relaxation and filling and reduced peak filling rate, with the severity of the abnormalities depending on the patients' 326 F. C. age and duration of diabetes (von Bibra et al 2005;Dounis et al 2006;Markuszewski et al 2006;Sharman et al 2007).…”