Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: a systematic review

Dadashi, Masoud; Sameni, Fatemeh; Bostanshirin, Nazila; Yaslianifard, Somayeh; Khosravi-Dehaghi, Nafiseh; Nasiri, Mohammad Javad; Goudarzi, Mehdi; Hashemi, Ali; Hajikhani, Bahareh

doi:10.1016/j.jgar.2021.10.022

Cited by 52 publications

(39 citation statements)

References 192 publications

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“…Colistin resistance, which is especially associated with mobile genetic elements, such as (mcr) genes, emerged as a major threat to the control of infections caused by Gram-negative bacteria. Dadashi et al (2021) investigated the global prevalence of mcr-mediated colistin-resistant E. coli clinical isolates in Oceania, Africa, America, Europe, and Asia, which were 0.32, 2.27, 5.19, 25.49, and 66.72, respectively. Their research included 79% of the works published between 2014 and 2020 ( Dadashi et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“… Dadashi et al (2021) investigated the global prevalence of mcr-mediated colistin-resistant E. coli clinical isolates in Oceania, Africa, America, Europe, and Asia, which were 0.32, 2.27, 5.19, 25.49, and 66.72, respectively. Their research included 79% of the works published between 2014 and 2020 ( Dadashi et al, 2021 ). Shen et al (2018) investigated 774 non-duplicate MCR-1-positive E. coli (MCRPEC) isolates from 774 stool samples collected from 5,159 healthy individuals in 30 provinces and municipalities in 2016, with MCRPEC prevalence ranging from 3.7 to 32.7% (average: 15.0%)—substantially higher than previously reported ( Shen et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Bacterial Resistance of Escherichia coli From Swine in Large-Scale Pig Farms in Beijing

Liu

Liu²,

Cheng

et al. 2022

Front. Microbiol.

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With widespread use of antibiotics in the aquaculture industry, bacterial resistance has recently attracted increasing attention. Continuous emergence of multi-resistant bacteria has greatly threatened human and animal health, as well as the quality and safety of livestock products. To control bacterial resistance, the effect of bacterial resistance needs to be well understood. The purpose of this study was to explore the factors influencing Escherichia coli (E. coli) drug resistance in large-scale pig farms. In this study, 296 strains of E. coli isolated and identified from large-scale pig farms in Beijing were used as the research objects. In vitro drug sensitivity tests were used to determine the sensitivity to 10 antibiotics of pig-derived E. coli. SPSS logistic regression was employed to analyze the effects of the season, pig type, sampling point (medication type) and sampling location on resistance and multi-drug resistance of E. coli from pigs. The degrees of drug resistance to 10 antibiotics of the 296 strains of pig-derived E. coli were varied, their resistance rates were between 4.05 and 97.64%, and their multi-drug resistance was appalling, with the highest resistance to six antibiotics being 26.35%. The isolated strains were proven more resistant to tetracyclines, penicillin and chloramphenicol, which are commonly used for disease prevention in pig farms, and less resistant to quinolones and aminoglycosides, which are not used in pig farms. The resistance of the isolated strains in spring and summer was generally higher than that in winter. E. coli resistance in piglets, fattening pigs and sows was more serious than that in nursery and sick pigs. The results showed that the season, type of medication and type of pig had an influence on the pig-derived E. coli resistance, among which the type of medication was the most influencing factor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Bacterial Resistance of Escherichia coli From Swine in Large-Scale Pig Farms in Beijing

Liu

Liu²,

Cheng

et al. 2022

Front. Microbiol.

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“…In particular, ST410 isolates have been reported in Asia (China and Vietnam), Europe (Italy), and America (Brazil), while ST617 isolates have been described in Asia (China, Korea, and Taiwan), and Europe (France and Italy). Alternatively, ST4 isolates have been reported in Arabia Saudi [ 68 ]. It is noteworthy that at present, there is no information regarding the prevalence or distribution of E. coli ST410 and ST617 lineages in Mexico, and the unique report of a single human-derived ETEC strain belonging to the ST4 lineage is by Saldaña-Ahuactzi et al [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617

et al. 2022

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Aquatic environments are recognized as one of the main reservoirs for the emergence and dissemination of high-risk lineages of multidrug-resistant (MDR) bacteria of public health concern. However, the genomic characteristics of antibiotic-resistant Escherichia coli isolates from aquatic origins remain limited. Herein, we examined the antibiotic resistance and virulence genomic profiles of three E. coli recovered from surface water in northwest Mexico. Antimicrobial susceptibility testing, whole-genome sequencing (WGS), and in-depth in silico analysis were performed. Two E. coli exhibited MDR phenotypes. WGS-based typing revealed genetic diversity, and phylogenetic analysis corroborated a notable divergent relationship among the studied E. coli. One E. coli strain, harboring enterotoxigenic and extraintestinal pathogenic-associated virulence genes, was assigned to the ST4 lineage. MDR E. coli, belonging to the international high-risk clones ST410 and ST617, carried genes and mutations conferring resistance to aminoglycosides, β-lactams, quinolones, sulfonamides, tetracyclines, and trimethoprim. This study describes, for the first time, the detection and genomic profiling of high-risk lineages of E. coli ST410 and ST617 from surface water in Mexico. Additionally, our results underscore the role of surface water as a reservoir for critical pathogenic and MDR E. coli clones and the need for the surveillance and monitoring of aquatic environments via WGS from the One Health perspective.

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“…The major clonal group was composed of ST359 and its double-locus variant, ST101, included six isolates. Both ST359 and ST101 have been previously reported among mcr -positive isolates of human and animal origin in Asia, Europe, Americas and Oceania [ 67 ]. The two K. pneumoniae isolates with mcr-1 were assigned to ST307 and ST23, which are both known as international ‘high-risk clones’ and have been commonly found in clinical settings in Russia [ 68 , 69 , 70 , 71 , 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of mcr-1-Positive Escherichia coli and Klebsiella pneumoniae Isolates: Results from Russian Sentinel Surveillance (2013–2018)

et al. 2022

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Background: The dissemination of mobile colistin resistance (mcr) genes is a serious healthcare threat because polymyxins represent “last-line” therapeutics for multi-drug-resistant Gram-negative pathogens. This study aimed to assess the prevalence of colistin resistance and mcr genes and characteristics of clinical Escherichia coli (Eco) and Klebsiella pneumoniae (Kpn) isolates and plasmids carrying these genes in Russia. Methods: A total of 4324 Eco and 4530 Kpn collected in the frame of sentinel surveillance in 2013–2018 were tested for susceptibility to colistin and other antibiotics using the broth microdilution method. mcr genes were screened by real-time PCR. Phylogeny, genomic features and plasmids of mcr-positive isolates were assessed using whole-genome sequencing and subsequent bioinformatic analysis. Results: Colistin resistance was detected in 2.24% Eco and 9.3% Kpn. Twenty-two (0.51%) Eco and two (0.04%) Kpn from distant sites carried mcr-1.1. Most mcr-positive isolates co-harbored ESBLs and other resistance determinants to various antibiotic classes. The mcr-positive Eco belonged to 16 MLST types, with ST359 being most common; Kpn belonged to ST307 and ST23. mcr-1.1 was carried mainly in IncI2 (n = 18) and IncX4 (n = 5) plasmids highly similar to those identified previously in human, animal and environmental isolates. Conclusion: This study demonstrated a dissemination of “typical” mcr-bearing plasmids among diverse Eco and Kpn genotypes and across a wide geographic area in Russia. Given the frequent association of mcr with other resistance determinants and potential clinical impact, the continual surveillance of this threat is warranted.

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Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: a systematic review

Cited by 52 publications

References 192 publications

Effect of Bacterial Resistance of Escherichia coli From Swine in Large-Scale Pig Farms in Beijing

Effect of Bacterial Resistance of Escherichia coli From Swine in Large-Scale Pig Farms in Beijing

Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617

Molecular Epidemiology of mcr-1-Positive Escherichia coli and Klebsiella pneumoniae Isolates: Results from Russian Sentinel Surveillance (2013–2018)

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