Global prevalence of ankylosing spondylitis

Dean, Linda E; Jones, Gareth T; MacDonald, Alan G.; Downham, Christina; Sturrock, R. D.; Macfarlane, Gary J.

doi:10.1093/rheumatology/ket387

Cited by 555 publications

(419 citation statements)

References 31 publications

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“…Based on the literature, it is believed that, on a worldwide basis, the disease prevalence is between 0.02% to 0.35% and even higher for people with low socioeconomic status 5 . The disease manifest more frequently in men than in women and its appearance is more usual during the third decade of life and rarely after the age of 45 years 6,7 . The cause of AS is still unknown, although genetic and infectious factors appear to have a significant contribution in triggering inflammatory mechanisms through which the disease can develop.…”

Section: Introductionmentioning

confidence: 99%

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

Kalogeropoulou¹

2017

JRPMS

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Section: Introductionmentioning

confidence: 99%

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

Kalogeropoulou¹

2017

JRPMS

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“…Epidemiological studies have estimated the AS prevalence per 10 000 persons to be 18.6 (in Europe), 18.0 (in Asia) and 12.2 (in Latin America). 12 The progressive biomechanical skeletal degradation augments the susceptibility of the spine for fractures in AS patients, even after low-energy impacts. 13,14 Two decades of old paradigm postulates that a stiff (ankylosed) and osteoporotic spine is prone to fractures, even after a trivial trauma.…”

Section: Introductionmentioning

confidence: 99%

“…12 Spinal fractures in AS are usually associated with advanced age and a longstanding disease, impaired back mobility, syndesmophyte formation, lower bone mineral density and deteriorated microarchitecture in both the axial and the peripheral skeleton. [14][15][16][17] In about two third of the cases, the main etiology consists of falls from standing or sitting position, the cervical region being the most frequently injured (in about 81% cases).…”

Section: Introductionmentioning

confidence: 99%

Evolution of traumatic spinal cord injury in patients with ankylosing spondylitis, in a Romanian rehabilitation clinic

Anghelescu

Onose²,

Popescu

et al. 2016

Spinal Cord Ser Cases

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The ankylosing spondylitis (AS) is a systemic, multi-factorial, chronic rheumatic disease. Patients are highly susceptible to vertebral fractures with or without spinal cord injury (AS-SCI), even after a minor trauma. The study is a retrospective descriptive survey of post-acute, traumatic AS-SCI patients, transferred from the neurosurgical department and admitted in a Romanian Neurorehabilitation Clinic, during 2010-2014. There were 11 males associating AS-SCI (0.90% of all consecutive SCI admitted cases), with an average age of 54.6 years (median 56, limits 42-73 years). The average duration between the medically diagnosed AS and the actual associated spinal fracture(-s) moment was 21.4 years (median 23; limits 10-34 years). Low-energy trauma was incriminated in 54.5% cases. The spinal level of fracture was: cervical (four cases), thoracic (three), lumbar (four), assessed at admission as: American Spinal Injury Association (ASIA) Impairment Scale (AIS) A (four subjects), C (five) and D (two). By the time of discharge, neither patient has neurologically deteriorated; five patients (45.5%) improved of at least grade 1 (AIS). The overall complications were mainly infections: symptomatic urinary tract infections (seven patients; 63.6%), pulmonary (three subjects; 27.3%) and spondylodiscitis (one case; 9%). The average follow-up period was 15.3 months (median 12; limits 1-48 months) after discharge; three subjects gained functional improvement to AIS-E. The clinical profile (different risk factors, mechanisms, types and levels of spinal fractures, additional encephalic and/or cord lesions, co-morbidities), different post-surgical and/or general complications acquired during admission in our rehabilitation ward, served us for future prevention strategies and a better therapeutic management.

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“…Hastalığın belirtileri ve prevalansı, cinsiyete, yaşa ve ırka göre değişkenlik göstermektedir. Prevalansı Avrupa'da 10.000'de 23.8, Asya'da 16.7, Kuzey Amerika'da 31.9 ve Afrika'da 7.4 olarak bildirilmiştir [2]. AS'te başlangıç yaşı genellikle 20'li ve 30'lu yaşlardır; erkeklerde görül-me sıklığı kadınlarda görülme sıklığına göre daha yüksek-tir.…”

Section: Introductionunclassified

Association of HLA-B27, MEFV gene mutations, ERAP1, IL12B and IL23R gene polymorphisms with ankylosing spondylitis.

Pekacar¹,

Akdoğan²,

Hayran³

et al. 2014

Turk J Bioch

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][Association of HLA-B27, MEFV gene mutations, ERAP1, IL12B and IL23R gene polymorphisms with ankylosing spondylitis] ABSTRACT Objective: Genetic factors have an important role in the pathogenesis of ankylosing spondylitis (AS). The aim of this study was to analyse the association of HLA-B27, MEFV mutations, IL12B, IL23R and ERAP1 polymorphisms in Turkish patients with ankylosing spondylitis. Methods: One hundred AS patients and 100 healthy controls were examined for HLA-B27, 12 common MEFV mutations, IL12B (rs3213120), IL23R (rs11209026), and ERAP1 (rs30187) polymorphisms (SNPs) by allele specific PCR, revers hybridization and sequencing techniques. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) scores were calculated. Results: Our results confirmed that HLA-B27 was strongly associated with AS (69% vs 7% in controls) (p<0.001, OR: 29.6, 95% CI: 12.3-71.1). We also found an association between uveitis and HLA-B27 positivity in AS patients (p=0.004). The MEFV mutations were significantly frequent in AS patients (40%) compared with healthy controls (22%) (p=0.006, OR: 2.56, 95% CI: 1.3-4.4). We found that ERAP1 rs30187 was significantly associated with AS patients (p=0.033). The rs30187 CT genotype was associated with increased AS risk compared to CC or TT genotypes (OR: 2.1, 95% CI: 1.2-3.7). However, in patients with AS carrying the C allele increased the risk 1.9 times (95% Cl: 1.1-3.3). There was no association with AS and IL12B (rs3213120) and IL23R (rs11209026). There were no significant differences between HLA-B27, MEFV mutations, ERAP1 (rs30187) and Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI) scores. Conclusion: This study showed that HLA-B27, MEFV mutations and ERAP1 (rs30187) are AS genetic susceptibility genes. Interactions between ERAP1 and HLA-B27 and MEFV mutations may play an important role in the AS pathogenesis.

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Global prevalence of ankylosing spondylitis

Cited by 555 publications

References 31 publications

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

Evolution of traumatic spinal cord injury in patients with ankylosing spondylitis, in a Romanian rehabilitation clinic

Association of HLA-B27, MEFV gene mutations, ERAP1, IL12B and IL23R gene polymorphisms with ankylosing spondylitis.

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