Global proteomic analysis reveals lysine succinylation contributes to the pathogenesis of aortic aneurysm and dissection

Zhang, Hongwei; Wang, Haiyue; Yang, Ping; Chen, Lu; Liu, Yu; Xu, Zhi‐Kang; Wang, Chenhao; Hu, Jia

doi:10.1016/j.jprot.2023.104889

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Succinylation has also been implicated in the regulation of mitochondrial function and oxidative stress response ( 8 , 20 ). Dysregulation of succinylation has been associated with various metabolic disorders ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, succinylation of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase, enhances its activity, leading to increased flux through the glycolytic pathway (16)(17)(18)(19). Succinylation has also been implicated in the regulation of mitochondrial function and oxidative stress response (8,20). Dysregulation of succinylation has been associated with various metabolic disorders (21, 22).…”

Section: Introductionmentioning

confidence: 99%

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Protein succinylation: regulating metabolism and beyond

Hou,

Chen,

et al. 2024

Front. Nutr.

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Modifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation modifications identified, particularly through recent mass spectrometry analysis. Among them, succinylation (Ksuc) on protein lysine residues causes a variety of biological changes. Succinylation of proteins contributes to many cellular processes such as proliferation, growth, differentiation, metabolism and even tumorigenesis. Mechanically, Succinylation leads to conformation alteration of chromatin or remodeling. As a result, transcription/expression of target genes is changed accordingly. Recent research indicated that succinylation mainly contributes to metabolism modulations, from gene expression of metabolic enzymes to their activity modulation. In this review, we will conclude roles of succinylation in metabolic regulation of glucose, fat, amino acids and related metabolic disease launched by aberrant succinylation. Our goal is to stimulate extra attention to these still not well researched perhaps important succinylation modification on proteins and cell processes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protein succinylation: regulating metabolism and beyond

Hou,

Chen,

et al. 2024

Front. Nutr.

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Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection

Feng,

Yi,

Huo

et al. 2024

Antioxidants & Redox Signaling

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Post‐translational modifications of proteins in cardiovascular diseases examined by proteomic approaches

Stastna

2024

The FEBS Journal

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Over 400 different types of post‐translational modifications (PTMs) have been reported and over 200 various types of PTMs have been discovered using mass spectrometry (MS)‐based proteomics. MS‐based proteomics has proven to be a powerful method capable of global PTM mapping with the identification of modified proteins/peptides, the localization of PTM sites and PTM quantitation. PTMs play regulatory roles in protein functions, activities and interactions in various heart related diseases, such as ischemia/reperfusion injury, cardiomyopathy and heart failure. The recognition of PTMs that are specific to cardiovascular pathology and the clarification of the mechanisms underlying these PTMs at molecular levels are crucial for discovery of novel biomarkers and application in a clinical setting. With sensitive MS instrumentation and novel biostatistical methods for precise processing of the data, low‐abundance PTMs can be successfully detected and the beneficial or unfavorable effects of specific PTMs on cardiac function can be determined. Moreover, computational proteomic strategies that can predict PTM sites based on MS data have gained an increasing interest and can contribute to characterization of PTM profiles in cardiovascular disorders. More recently, machine learning‐ and deep learning‐based methods have been employed to predict the locations of PTMs and explore PTM crosstalk. In this review article, the types of PTMs are briefly overviewed, approaches for PTM identification/quantitation in MS‐based proteomics are discussed and recently published proteomic studies on PTMs associated with cardiovascular diseases are included.

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Global proteomic analysis reveals lysine succinylation contributes to the pathogenesis of aortic aneurysm and dissection

Cited by 5 publications

References 33 publications

Protein succinylation: regulating metabolism and beyond

Protein succinylation: regulating metabolism and beyond

Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection

Post‐translational modifications of proteins in cardiovascular diseases examined by proteomic approaches

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