Global, regional, and country estimates of metabolic syndrome burden in children and adolescents in 2020: a systematic review and modelling analysis

Noubiap, Jean Jacques; Nansseu, Jobert Richie; Lontchi-Yimagou, Eric; Nkeck, Jan René; Nyaga, Ulrich Flore; Ngouo, Anderson; Tounouga, Dahlia Noëlle; Tianyi, Frank-Leonel; Foka, Audrey Joyce; Ndoadoumgue, Aude Laetitia; Bigna, Jean Joël

doi:10.1016/s2352-4642(21)00374-6

Cited by 146 publications

(91 citation statements)

References 32 publications

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“…The frequency of the A-allele in our study cohort of Arab individuals is 16.6%, with the sub-cohort of individuals with MetS exhibiting a higher value of 21% compared to 14% exhibited by the sub-cohort of MetS-free individuals. Considerable regional and global variation in the estimates for MetS burden on both children (Noubiap et al, 2022) and adults (Ranasinghe et al, 2017;Moreira et al, 2020) have also been reported. These variations in the prevalence of MetS across the populations are probably consistent with variations in the effect allele frequencies and with the association signals across the populations.…”

Section: Discussionmentioning

confidence: 99%

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians

Madhoun

Hebbar²,

Nizam³

et al. 2022

Front. Genet.

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Background: Animal and cell model studies have implicated CAV1 in the pathophysiology of metabolic disorders. Our previous studies demonstrated a potential association of CAV1 rs1997623 C/A variant with pediatric metabolic syndrome (MetS) in Arab children. In the present study, we evaluate whether the CAV1 variant associates with MetS Arab adults as well. The association signal is further examined for ancestry-specific variation by considering cohorts of other ethnicities.Method: The CAV1 rs1997623 was genotyped in three cohorts of Arab (n = 479), South Asian (n = 660), and South East Asian (n = 362) ethnic adults from Kuwait. MetS status of the individuals was diagnosed using the IDF criteria (presence of central obesity and at least two abnormalities out of: elevated TG, low HDL, hypertension, or T2D). The quantitative measure of MetS was calculated as siMS = 2 × WC/Height + FBG/5.6 + TG/1.7 + SBP/130–HDL/1.02 for males or HDL/1.28 for females. Allelic associations with quantitative and dichotomous MetS traits were assessed using linear and logistic regression models adjusted for age and sex. In addition, empirical p-values (Pemp) were generated using max(T) permutation procedure based on 10,000 permutations.Results: The CAV1 variant was significantly associated with MetS status (OR = 1.811 [1.25–2.61]; p-value = 0.0015; Pemp = 0.0013) and with siMS (Effect size = 0.206; p-value = 0.0035; Pemp = 0.0028) in the cohort of Arab individuals. The association was weak and insignificant in the South Asian and South East Asian cohorts (OR = 1.19 and 1.11; p-values = 0.25 and 0.67, respectively).Conclusion: The reported association of CAV1 rs1997623 C/A with MetS in Arab pediatric population is now demonstrated in an adult Arab cohort as well. The weak association signal seen in the Asian cohorts lead us to propose a certain extent of ethnic-specificity in CAV1 rs1997623 association with MetS.

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Section: Discussionmentioning

confidence: 99%

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians

Madhoun

Hebbar²,

Nizam³

et al. 2022

Front. Genet.

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“…In addition, recent evidence shows that worldwide, about 3% of children and 5% of adolescents have MetS. 31…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease

Åberg¹,

Byrne²,

Pirola³

et al. 2023

Journal of Hepatology

120

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“…Central obesity is a marker of insulin resistance, the underlying pathogenic disorder for the development of the metabolic syndrome and T2DM [ 42 ]. Consequently, central obesity is a strong risk factor for metabolic syndrome [ 43 ] and is one of the criteria for its diagnosis [ 44 ]. In Saudi Arabia, where central obesity prevalence is lower than in Qatar [ 40 ], metabolic syndrome among adolescents (12–18 years old) was four times higher than the global estimate (20.6% in 2019 [ 40 ] vs. 5% in 2020 [ 44 ]), suggesting that metabolic syndrome is likely also of concern among adolescents in Qatar.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Overweight, Obesity, Central Obesity, and Type 2 Diabetes among Adolescents in Qatar: A Cross-Sectional Study

Cheema

Abraham

El-Nahas

et al. 2022

IJERPH

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Qatar has a high obesity and type 2 diabetes mellitus (T2DM) burden. This study aimed to (1) determine the prevalence of overweight, obesity, and T2DM in 13–17-year-old adolescents and (2) evaluate associations with adolescents’ lifestyle and breastfeeding history, parental weight, and familial T2DM history. A cross-sectional study (double-stage cluster sampling) was conducted in 2018–2020 using a self-administered parental and adolescent questionnaire. In the results, 23.4% of the adolescents (107/459) were overweight; 19.9% (91/459) were obese; and 37.6% (171/459) had evidence of central obesity. Random blood sugar (RBS) was suggestive of prediabetes (≥140 mg/dL) for 23 (5.0%) adolescents and T2DM (≥200 mg/dL) for none. In multivariable analysis, obesity was significantly associated with no breastfeeding (OR = 3.17, 95% CI: 1.09–9.26) compared to breastfed adolescents for ≥6 months, with first-degree family history of T2DM (OR = 2.27; 95% CI: 1.22–4.27), with maternal obesity (OR = 2.40; 95% CI: 1.01–5.70), and with acanthosis nigricans in adolescents (OR = 19.8; 95% CI: 8.38–46.9). Central obesity was significantly associated with maternal obesity (OR = 2.21; 95% CI: 1.14–4.27) and with acanthosis nigricans (OR = 3.67; 95% CI: 1.88–7.18). Acanthosis nigricans (OR = 4.06; 95% CI: 1.41–11.7) was the only factor associated with elevated RBS. Addressing future disease burden among adults in Qatar will require extensive health and well-being programs, focused on healthy lifestyles and behaviors such as nutritious diets, physical activity, stress management, and self-care.

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Global, regional, and country estimates of metabolic syndrome burden in children and adolescents in 2020: a systematic review and modelling analysis

Cited by 146 publications

References 32 publications

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians

Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease

Assessment of Overweight, Obesity, Central Obesity, and Type 2 Diabetes among Adolescents in Qatar: A Cross-Sectional Study

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