Global research status and frontiers on microvascular invasion of hepatocellular carcinoma: A bibliometric and visualized analysis

He, Tao; Zou, Jieyu; Sun, Ke; Yang, Juan; Lei, Tingting; Xu, Lin; Liu, Jin-Heng; Yin, Sineng; Li, Guangkuo

doi:10.3389/fonc.2022.1037145

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…Despite a thorough analysis, we were unable to demonstrate a significant impact of D-HOPE on HCC recurrence. In our series, HCC recurrence was closely associated with HCC features, such as microvascular invasion and tumor grading, which is consistent with the evidence from the literature [ 82 , 83 ]. In contrast with the findings from the Zurich group [ 55 ], even after adjusting for potential confounders, we did not observe any significant differences in HCC recurrence rate between recipients of a D-HOPE-treated graft and those who received a graft preserved by SCS.…”

Section: Discussionsupporting

confidence: 92%

Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation

Rigo

Stefano

Patrono

et al. 2023

JPM

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Background: Machine perfusion may be able to mitigate ischemia-reperfusion injury (IRI), which increases hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). This study aimed to investigate the impact of dual-hypothermic oxygenated machine perfusion (D-HOPE) on HCC recurrence in LT. Methods: A single-center retrospective study was conducted from 2016 to 2020. Pre- and postoperative data of HCC patients undergoing LT were analyzed. Recipients of a D-HOPE-treated graft were compared to those of livers preserved using static cold storage (SCS). The primary endpoint was recurrence-free survival (RFS). Results: Of 326 patients, 246 received an SCS-preserved liver and 80 received a D-HOPE-treated graft (donation after brain death (DBD), n = 66; donation after circulatory death (DCD), n = 14). Donors of D-HOPE-treated grafts were older and had higher BMI. All DCD donors were treated by normothermic regional perfusion and D-HOPE. The groups were comparable in terms of HCC features and estimated 5-year RFS according to the Metroticket 2.0 model. D-HOPE did not reduce HCC recurrence (D-HOPE 10%; SCS 8.9%; p = 0.95), which was confirmed using Bayesian model averaging and inverse probability of treatment weighting-adjusted RFS analysis. Postoperative outcomes were comparable between groups, except for lower AST and ALT peak in the D-HOPE group. Conclusions: In this single-center study, D-HOPE did not reduce HCC recurrence but allowed utilizing livers from extended criteria donors with comparable outcomes, improving access to LT for patients suffering from HCC.

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Section: Discussionsupporting

confidence: 92%

Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation

Rigo

Stefano

Patrono

et al. 2023

JPM

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“…Previous studies have established that the presence of MVI is one of the key factors in early recurrence of HCC and poor outcomes after curative liver resection or liver transplantation. 13 Preoperative assessment of MVI is important for accurate selection of candidates for the various treatment options. For example, studies in which MVI status was evaluated preoperatively found that the rate of early recurrence was lower after surgical resection than after radiofrequency ablation and that anatomical resection was superior to nonanatomical resection.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MRI Features for Predicting Microvascular Invasion and Postoperative Recurrence in Hepatocellular Carcinoma Without Peritumoral Hypointensity

Chen,

Li,

Zhang

et al. 2023

JHC

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Purpose To identify MRI features of hepatocellular carcinoma (HCC) that predict microvascular invasion (MVI) and postoperative intrahepatic recurrence in patients without peritumoral hepatobiliary phase (HBP) hypointensity. Patients and Methods One hundred and thirty patients with HCC who underwent preoperative gadoxetate-enhanced MRI and curative hepatic resection were retrospectively reviewed. Two radiologists reviewed all preoperative MR images and assessed the radiological features of HCCs. The ability of peritumoral HBP hypointensity to identify MVI and intrahepatic recurrence was analyzed. We then assessed the MRI features of HCC that predicted the MVI and intrahepatic recurrence-free survival (RFS) in the subgroup without peritumoral HBP hypointensity. Finally, a two-step flowchart was constructed to assist in clinical decision-making. Results Peritumoral HBP hypointensity (odds ratio, 3.019; 95% confidence interval: 1.071–8.512; P =0.037) was an independent predictor of MVI. The sensitivity, specificity, positive predictive value, negative predictive value, and AUROC of peritumoral HBP hypointensity in predicting MVI were 23.80%, 91.04%, 71.23%, 55.96%, and 0.574, respectively. Intrahepatic RFS was significantly shorter in patients with peritumoral HBP hypointensity ( P <0.001). In patients without peritumoral HBP hypointensity, the only significant difference between MVI-positive and MVI-negative HCCs was the presence of a radiological capsule ( P =0.038). Satellite nodule was an independent risk factor for intrahepatic RFS (hazard ratio,3.324; 95% CI: 1.733–6.378; P <0.001). The high-risk HCC detection rate was significantly higher when using the two-step flowchart that incorporated peritumoral HBP hypointensity and satellite nodule than when using peritumoral HBP hypointensity alone ( P <0.001). Conclusion In patients without peritumoral HBP hypointensity, a radiological capsule is useful for identifying MVI and satellite nodule is an independent risk factor for intrahepatic RFS.

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“…RMI based on ultrasonography, menopausal status, and serum CA125 levels can quantitatively assess the risk of malignancy for accurate preoperative diagnosis of OC ( 25 ). Analyzing keyword bursts can help researchers in identifying the frontier or future trends in specific fields ( 35 ). The keyword with the highest burst intensity is pelvic masses, spanning from 2007 to 2012.…”

Section: Discussionmentioning

confidence: 99%

Application of medical imaging in ovarian cancer: a bibliometric analysis from 2000 to 2022

Leng,

Li,

Zhu

et al. 2023

Front. Oncol.

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BackgroundOvarian cancer (OC) is the most lethal tumor within the female reproductive system. Medical imaging plays a significant role in diagnosis and monitoring OC. This study aims to use bibliometric analysis to explore the current research hotspots and collaborative networks in the application of medical imaging in OC from 2000 to 2022.MethodsA systematica search for medical imaging in OC was conducted on the Web of Science Core Collection on August 9, 2023. All reviews and articles published from January 2000 to December 2022 were downloaded, and an analysis of countries, institutions, journals, keywords, and collaborative networks was perfomed using CiteSpace and VOSviewer.ResultsA total of 5,958 publications were obtained, demonstrating a clear upward trend in annual publications over the study peroid. The USA led in productivity with 1,373 publications, and Harvard University emerged as the most prominent institution with 202 publications. Timmerman D was the most prolific contributor with 100 publications, and Gynecological Oncology led in the number of publications with 296. The top three keywords were “ovarian cancer” (1,256), “ultrasound” (725), and “diagnosis” (712). In addition, “pelvic masses” had the highest burst strength (25.5), followed by “magnetic resonance imaging (MRI)” (21.47). Recent emergent keywords such as “apoptosis”, “nanoparticles”, “features”, “accuracy”, and “human epididymal protein 4 (HE 4)” reflect research trends in this field and may become research hotspots in the future.ConclusionThis study provides a comprehensive summary of the key contributions of OC imaging to field’s development over the past 23 years. Presently, primary areas of OC imaging research include MRI, targeted therapy of OC, novel biomarker (HE 4), and artificial intelligence. These areas are expected to influence future research endeavors in this field.

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Global research status and frontiers on microvascular invasion of hepatocellular carcinoma: A bibliometric and visualized analysis

Cited by 5 publications

References 33 publications

Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation

Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation

MRI Features for Predicting Microvascular Invasion and Postoperative Recurrence in Hepatocellular Carcinoma Without Peritumoral Hypointensity

Application of medical imaging in ovarian cancer: a bibliometric analysis from 2000 to 2022

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