Global Sensitivity Analysis for a perfusion bioreactor system in tissue engineering

Nașcu, Ioan; Chen, Tao; Du, Wenli

doi:10.1016/j.ifacol.2021.10.314

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…The results showed that the maximum shear stress and average shear stress of the inverted hybrid bioreactor were significantly lower than those of the conventional rotary hybrid bioreactor ( Zhao et al, 2005 ). The application of the bioreactor can greatly reduce cell damage, thus affecting the cells’ physiological activity, and finally improve the maximum cell growth density ( Nascu et al, 2021 ).…”

Section: Using Computational Biology To Simulate Large-scale Upstream...mentioning

confidence: 99%

Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospects

Fang

Lyu

et al. 2022

Front. Bioeng. Biotechnol.

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Bioreactors are widely used in cell culture-based viral vaccine production, especially during the coronavirus disease 2019 (COVID-19) pandemic. In this context, the development and application of bioreactors can provide more efficient and cost-effective vaccine production to meet the global vaccine demand. The production of viral vaccines is inseparable from the development of upstream biological processes. In particular, exploration at the laboratory-scale is urgently required for further development. Therefore, it is necessary to evaluate the existing upstream biological processes, to enable the selection of pilot-scale conditions for academic and industrial scientists to maximize the yield and quality of vaccine development and production. Reviewing methods for optimizing the upstream process of virus vaccine production, this review discusses the bioreactor concepts, significant parameters and operational strategies related to large-scale amplification of virus. On this basis, a comprehensive analysis and evaluation of the various process optimization methods for the production of various viruses (SARS-CoV-2, Influenza virus, Tropical virus, Enterovirus, Rabies virus) in bioreactors is presented. Meanwhile, the types of viral vaccines are briefly introduced, and the established animal cell lines for vaccine production are described. In addition, it is emphasized that the co-development of bioreactor and computational biology is urgently needed to meet the challenges posed by the differences in upstream production scales between the laboratory and industry.

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Section: Using Computational Biology To Simulate Large-scale Upstream...mentioning

confidence: 99%

Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospects

Fang

Lyu

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Optimization and Control of a Perfusion Bioreactor System in Tissue Engineering

Nașcu

2022

2022 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR)

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Global Sensitivity Analysis for a perfusion bioreactor system in tissue engineering

Cited by 2 publications

References 18 publications

Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospects

Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospects

Optimization and Control of a Perfusion Bioreactor System in Tissue Engineering

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