Global sensitivity analysis for a perfusion bioreactor based on CFD modelling

Nașcu, Ioan; Sebastia‐Saez, Daniel; Chen, Tao; Du, Wenli

doi:10.1016/j.compchemeng.2022.107829

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…It is important to acknowledge that the experiments are not exempt from measurement inaccuracies, and these errors must be factored into the statistical analysis especially when multiple sensors are used to extract the same data. A few studies involving detailed kinetic models for cell metabolism have not been available to validate the results and have presented in silico results as proof-of-concept [ 36 , 38 , 75 , 87 , 95 , 96 ]. Table 4 summarises relevant available year-wise research outputs, studied cell culture system, adopted approaches, and validation strategy.…”

Section: State Of the Artmentioning

confidence: 99%

Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation

Singh,

Jiménez del Val,

Glassey

et al. 2024

Bioengineering

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Large-scale bioprocesses are increasing globally to cater to the larger market demands for biological products. As fermenter volumes increase, the efficiency of mixing decreases, and environmental gradients become more pronounced compared to smaller scales. Consequently, the cells experience gradients in process parameters, which in turn affects the efficiency and profitability of the process. Computational fluid dynamics (CFD) simulations are being widely embraced for their ability to simulate bioprocess performance, facilitate bioprocess upscaling, downsizing, and process optimisation. Recently, CFD approaches have been integrated with dynamic Cell reaction kinetic (CRK) modelling to generate valuable information about the cellular response to fluctuating hydrodynamic parameters inside large production processes. Such coupled approaches have the potential to facilitate informed decision-making in intelligent biomanufacturing, aligning with the principles of “Industry 4.0” concerning digitalisation and automation. In this review, we discuss the benefits of utilising integrated CFD-CRK models and the different approaches to integrating CFD-based bioreactor hydrodynamic models with cellular kinetic models. We also highlight the suitability of different coupling approaches for bioprocess modelling in the purview of associated computational loads.

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Section: State Of the Artmentioning

confidence: 99%

Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation

Singh,

Jiménez del Val,

Glassey

et al. 2024

Bioengineering

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Reactive Flow CFD Simulation for VOC Abatement: Model Validation Using Experimental Data for Propane Total Oxidation

Fatahillah,

Heynderickx,

Van Geem

et al. 2024

Ind. Eng. Chem. Res.

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A two-dimensional computational fluid dynamics (CFD) model for an annular fixed-bed chemical reactor, incorporating a radial bed porosity correlation, has been developed. The model was first validated against experimental data for the total oxidation of propane on a CuO-CeO 2 /γ-Al 2 O 3 catalyst using Langmuir−Hinshelwood kinetics, yielding a mean absolute relative error of 13%. The model accurately reflects the effects of the increased space time and oxygen inlet partial pressure on propane conversion across various temperatures. Following validation, the CFD model was employed to investigate propane total oxidation on a Co/ZSM-5 catalyst using Mars−van Krevelen kinetics, derived from different experimental setups, with the results qualitatively matching experimental trends under both dry and humid conditions. Finally, the model was used to compare the performance of the two catalysts under identical conditions, revealing that CuO-CeO 2 /γ-Al 2 O 3 outperforms Co/ZSM-5, with the performance difference narrowing at higher temperatures.

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Optimization and Control of a Perfusion Bioreactor System in Tissue Engineering

Nașcu

2022

2022 IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR)

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Global sensitivity analysis for a perfusion bioreactor based on CFD modelling

Cited by 3 publications

References 37 publications

Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation

Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation

Reactive Flow CFD Simulation for VOC Abatement: Model Validation Using Experimental Data for Propane Total Oxidation

Optimization and Control of a Perfusion Bioreactor System in Tissue Engineering

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