SUMMARYA recent paper (IEEE Trans. Aut. Contr. 2010; 55(9):2156-2160) considered stabilization of a class of continuous-time nonlinear sandwich systems via state feedback. This paper is a discrete-time counterpart of it. The class of nonlinear sandwich systems consists of saturation elements sandwiched between linear systems. We focus first on single-layer sandwich systems, which consist of a single saturation sandwiched between two linear systems. For such systems, we present necessary and sufficient conditions for semi-global and global stabilization problems by state feedback, and develop design methodologies to achieve the prescribed stabilization. We extend the results to single-layer sandwich systems subject to additional actuator saturation. Finally, we discuss further extension to general multi-layer sandwich systems with an arbitrary number of saturations sandwiched between linear systems, both with and without actuator saturation. The design methodologies can be viewed as extensions of classical low-gain design methodologies developed during the 1990s in the context of stabilizing linear systems subject to actuator saturation.