Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Conlledo, Rodrigo; Rodríguez, Álvaro; Godoy, Javiera; Merino, Carlos Adolfo; Martínez, Felipe

doi:10.4067/s0716-10182012000200012

Cited by 3 publications

(2 citation statements)

References 44 publications

(42 reference statements)

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“…Second, the results of the statistic analysis were not powerful enough to get such a solid conclusion. More recently, a study performed by Conlledo et al confirmed that early lymphocyte count was independently associated with increased mortality in patients with sepsis or septic shock [ 20 ]. Besides, the study also indicated that the absolute lymphocyte count was closely associated with late infection.…”

Section: Discussionmentioning

confidence: 99%

Reduced lymphocyte count as an early marker for predicting infected pancreatic necrosis

Shen

Sun

et al. 2015

BMC Gastroenterol

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BackgroundEarly occurrence of immunosuppression is a risk factor for infected pancreatic necrosis (IPN) in the patients with acute pancreatitis (AP). However, current measures for the immune systems are too cumbersome and not widely available. Significantly decreased lymphocyte count has been shown in patients with severe but not mild type of AP. Whereas, the correlation between the absolute lymphocyte count and IPN is still unknown. We conduct this study to reveal the exact relationship between early lymphocyte count and the development of IPN in the population of AP patients.MethodsOne hundred and fifty-three patients with acute pancreatitis admitted to Jinling Hospital during the period of January 2012 to July 2014 were included in this retrospective study. The absolute lymphocyte count and other relevant parameters were measured on admission. The diagnosis of IPN was based on the definition of the revised Atlanta classification.ResultsPatients were divided into two groups according to the presence of IPN. Thirty patients developed infected necrotizing pancreatitis during the disease course. The absolute lymphocyte count in patients with IPN was significantly lower on admission (0.62 × 109/L, interquartile range [IQR]: 0.46–0.87 × 109/L vs. 0.91 × 109/L, IQR: 0.72–1.27 × 109/L, p < 0.001) and throughout the whole clinical course than those without IPN. Logistic regression indicated that reduced lymphocyte count was an independent risk factor for IPN. The optimal cut-offs from ROC curve was 0.66 × 109/L giving sensitivity of 83.7 % and specificity of 66.7 %.ConclusionsReduced lymphocyte count within 48 h of AP onset is significantly and independently associated with the development of IPN.

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Section: Discussionmentioning

confidence: 99%

Reduced lymphocyte count as an early marker for predicting infected pancreatic necrosis

Shen

Sun

et al. 2015

BMC Gastroenterol

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“…La albúmina es de gran importancia en la estabilización y mantenimiento del volumen del líquido extracelular, que evita que el líquido del torrente sanguíneo se extravase al intersticio y tejidos; además, participa en la unión a oligoelementos, fármacos, vitaminas, entre otras funciones (9) . Las globulinas, proteínas globulares con un peso molecular superior al de las albúminas (10) , participan en la defensa del organismo combatiendo infecciones, en el transporte de sustancias, la coagulación sanguínea y los procesos enzimáticos (11) . La fosfatasa alcalina, proteína enzimática cuya función principal es la desfosforilación, está presente en todo el organismo, pero se halla principalmente en el hígado, las vías biliares, los riñones, los huesos y la mucosa intestinal (12) .…”

Section: Introductionunclassified

Correlación del recuento de eosinófilos con las proteínas totales y la fosfatasa alcalina en pacientes asintomáticos con niveles normales y elevados de aspartato aminotransferasa de un policlínico de Villa El Salvador en Lima-Perú

Guevara-Tirado

2022

Horizmed

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Objetivo: Evaluar la correlación del recuento diferencial de eosinófilos con niveles de proteínas totales y fosfatasa alcalina en pacientes con valores normales y elevados de aspartato aminotransferasa pertenecientes a un policlínico de Villa El Salvador en Lima, Perú. Materiales y métodos: Estudio observacional, analítico y correlacional realizado en pacientes de ambos sexos con edades iguales o mayores a 18 años, aparentemente sanos, con niveles normales y elevados de la enzima aspartato aminotransferasa. 279 pacientes cumplieron con los criterios de elegibilidad. Se utilizó la prueba de correlación de Spearman para determinar grado de correlación entre recuento de eosinófilos con fosfatasa alcalina y proteínas totales en pacientes con niveles normales y elevados de aspartato aminotransferasa. Resultados: No hubo correlación entre las variables estudiadas en el grupo con valores de aminotransferasas normales. Sin embargo, en el grupo que presentó valores de aspartato aminotransferasa elevados se encontró una correlación moderada y negativa entre el recuento de eosinófilos con las proteínas totales (Rho = -465) y correlación baja y positiva con la fosfatasa alcalina (Rho = 296). Conclusiones: En presencia de valores de aminotransferasas superiores al rango normal, los eosinófilos se correlacionan con las proteínas totales y la fosfatasa alcalina. Son necesarios estudios con mayor número de pacientes y complejidad metodológica para determinar si la interacción entre eosinófilos con la albúmina y la fosfatasa ocurre frecuentemente en condiciones de aminotransferasas elevadas, y considerar posibles implicaciones en la fisiopatología de las enfermedades crónicas asociadas a esta enzima, así como posibles repercusiones clínicas y terapéuticas.

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Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection

Liu

She

et al. 2021

Burns &Amp; Trauma

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Background The current study aimed to evaluate the value of immune cell counts and neutrophil-to-lymphocyte ratio (NLR) when attempting to predict 28-day mortality. Methods We conducted an observational retrospective study that included consecutive septic patients. Severity scores on the first day and peripheral circulating immune cell counts (at day 1, day 3, day 5 and day 7 of admission) were collected during each patient’s emergency intensive care unit stay. We assessed the associations of peripheral circulating immune cell counts and NLR with the severity of illness. The relationships between 28-day mortality and peripheral circulating immune cell counts and NLR with were evaluated using Cox proportional cause-specific hazards models. Results A total of 216 patients diagnosed with sepsis caused by IAI were enrolled. The lymphocyte counts (days 1, 3, 5 and 7) and monocyte counts (days 3, 5 and 7) were significantly lower in non-survivors (n = 72) than survivors (n = 144). The NLR values at each time point were significantly higher in non-survivors. The day 1 lymphocyte counts, as well as the monocyte counts, were significantly lower in the highest-scoring group, when stratified by the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores, than in the other groups (p < 0.05). The day 1 NLR was significantly higher in the highest-scoring group than in the other groups (p < 0.05). The day 5 and day 7 lymphocyte counts, day 3 and day 7 monocyte counts and day 7 NLR were significant predictors of 28-day mortality in the Cox proportional hazards models (day 5 lymphocyte count: hazard ratio, 0.123 (95% CI, 0.055–0.279), p < 0.001; day 7 lymphocyte count: hazard ratio, 0.115 (95% CI, 0.052–0.254), p < 0.001; day 3 monocyte count: hazard ratio, 0.067 (95% CI, 0.005–0.861), p = 0.038; day 7 monocyte count: hazard ratio, 0.015 (95% CI, 0.001–0.158), p < 0.001; day 7 NLR: hazard ratio, 0.773 (95% CI, 0.659–0.905), p = 0.001). Conclusions The results showed that circulating lymphocytes and monocytes were dramatically decreased within 7 days in non-survivors following sepsis from an IAI. Lymphocyte counts, monocyte counts and NLR appeared to be associated with the severity of illness, and they may serve as independent predictors of 28-day mortality in septic patients with IAIs.

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Globulinas totales y recuento linfocitario como marcadores de mortalidad en sepsis y shock séptico

Cited by 3 publications

References 44 publications

Reduced lymphocyte count as an early marker for predicting infected pancreatic necrosis

Reduced lymphocyte count as an early marker for predicting infected pancreatic necrosis

Correlación del recuento de eosinófilos con las proteínas totales y la fosfatasa alcalina en pacientes asintomáticos con niveles normales y elevados de aspartato aminotransferasa de un policlínico de Villa El Salvador en Lima-Perú

Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection

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