Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature

Abstract

Background Glomus tumors are rare mesenchymal tumors originating from glomus bodies in the skin. Glomus tumors of the kidney are rare tumors and only a few cases have been reported in the medical literature. An extensive search revealed a very limited number of primary renal glomus tumors. Although most of these cases were benign in nature, including a case with uncertain diagnosis of malignant potential, two were malignant. Case Report We present a unique case of a 57-year-old male patient with an incidentally discovered 2 cm left renal mass. Histopathology examination and immunohistochemical studies confirm the diagnosis of glomangioma (a form of glomus tumor). The patient was followed for one year after partial nephrectomy and showed a benign course without any evidence of local recurrence or metastasis. Conclusion To the best of our knowledge, this is the 16th case of primary benign renal glomus tumors. Primary renal glomus tumors are rare and may mimic other mesenchymal renal neoplasms radiologically. Proper investigation (including histopathological analysis and immunohistochemical staining) of kidney tumors is essential to make the diagnosis of glomus tumors, which usually show a benign clinical course following resection.

A Case of Ovarian Glomus Tumor and Literature Review

“…Surgical resection remains the treatment in choice described in other viscera and diagnosed by histopathology [12,13].The top differential diagnoses in this case based on hematoxylin and eosin (H and E) stained slides included cell surface epithelial carcinoma, sex-cord stromal tumor, neuroendocrine tumor, hepatoid carcinoma or metastatic gastrointestinal stromal tumor (GIST). Immunohistochemical staining using various markers such as pan-Cytokeratins alpha-inhibin, calretinin, synaptophysin, chromogranin, alpha fetoprotein, and c-Kit can be used to aid in the diagnosis.…”

Giant Ileocecal Inflammatory Fibroid Polyp: Unique Clinical Presentation

“…IMT is a spindled myoepithelial cell proliferation with lymphocytic infiltrate that mostly stained with ALK-1. Plexiform fibromyxoma is usually a multinodular concentric around muscularis propria which lacks blood vessels and negative for CD34 [ 24 ].…”

Vascular Neoplasms and Related Lesions of Kidney

“…The glomus tumor family is a group of pericytic neoplasms derived from the modified perivascular cells of the glomus body, and includes glomus tumor and its variants, glomangioma and glomangiomyoma [81]. Most cases occur in the distal extremities, with rare cases arising in the visceral organs; approximately 30 reports of renal glomus tumor and variants have been documented in the literature to date [81][82][83][84][85][86][87][88]. Patients presented within a wide age range (8 months to 81 years; mean 53 years) with hematuria, abdominal pain, palpable mass, or asymptomatically with an incidentally detected lesion [81].…”

“…On CT imaging, a well-demarcated, hypodense heterogeneous mass which shows moderate enhancement with contrast administration is typically seen [87,89]. Overall, no specific radiologic features have been identified and the findings are often suggestive of RCC, necessitating nephrectomy with histopathologic examination for definitive diagnosis [82,83].…”