Glomerular Cysts&lt;subtitle&gt;An Unusual Variety of "Polycystic Kidneys":&lt;/subtitle&gt;&lt;subtitle&gt;Report of Two Cases&lt;/subtitle&gt;

Vlachos, John

doi:10.1001/archpedi.1967.02090250077003

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…Similar cysts of the kidney have been re ported previously [6,14,[17][18][19]. but none in association with dysplastic kidneys and agen esis of the contralateral kidney.…”

Section: Discussionsupporting

confidence: 77%

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Morphogenesis of Glomerular Cysts in Renal Dysplasia

Pardo-Mindan¹,

Pablo²,

Vazquez³

1978

Nephron

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The glomerular origin and the morphogenesis of the cysts in a case of renal dysplasia are described. On light microscopy, islets of cartilage, immature ducts and cortical cysts were found. A primitive glomerular tuft was present in some cysts. On electron microscopy part of the inner surface of the cysts was lined by epithelium with pedicels. These findings suports the hypothesis that the cause of the cysts is the dilatation of the glomerular spaces when the respective glomeruli become functional.

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“…Similar cysts of the kidney have been re ported previously [6,14,[17][18][19]. but none in association with dysplastic kidneys and agen esis of the contralateral kidney.…”

Section: Discussionsupporting

confidence: 77%

“…Vlaclios and Tsakraklidis [19] consider the possibility of mild cases of poly cystic kidneys becoming more severe by pro gressive increase in the size and number of the cysts. This would explain why there is so much variation in the size of the kidney of similar reported cases [6,14,[17][18][19], according to the morphology of the cysts.…”

Section: Discussionmentioning

confidence: 99%

Morphogenesis of Glomerular Cysts in Renal Dysplasia

Pardo-Mindan¹,

Pablo²,

Vazquez³

1978

Nephron

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“…The cysts of the polycystic kidney are classified into four types with regard to their different origins (OSATHANONDH and POTTER, 1964;DU BoIs,1969;BERNSTEIN, 1973). The glomerular cysts are histologically identified by the presence of tufts of glomerular capillaries (VLACHOS and TSAKRAKLIDIS, 1967;TAXY and FILMER, 1976). Furthermore, PARDO-MINDAN, PABLO and VAzQuEz's (1978) electron microscope examination of the cysts in a case of renal dysplasia in man revealed the presence of an epithelium with pedicels on a part of the inner surface lining the cysts.…”

Section: Discussionmentioning

confidence: 99%

Scanning and transmission electron microscopy of cysts in the renal cortex of the macaque monkey.

Miyoshi

Ogawa

Shingu

et al. 1984

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary.Renal cysts in the cortex of the monkey kidney were observed by scanning and transmission electron microscopy, in an attempt to determine the three-dimensional structures of the epithelial cells in these cysts.The cysts were composed of a thin wall which limited a large spherical space containing a jelly-like substance and some wandering cells. Rudimentary tufts of glomerular capillaries and/or a mound-like swelling were present on the inner surface of the cyst wall, and the inner surface of the cysts was lined with an epithelium with pedicels. The epithelial cells were podocytes, whose surface structure was similar to that on the glomerular capillary in the normal renal corpuscle.The terminal foot processes were characteristically interdigitated not only on the glomerular capillaries, but also on the mound-like swelling and concave surface of the parietal portion of the cyst.A discrete, smooth-surfaced area was found on the side opposite to the glomerulus or swelling.This area was covered by squamous epithelial cells.At the peripheral zone of the smooth-surfaced area, elongated epithelial cells were demonstrated. Our findings indicate that the podocyte layer of the cyst corresponds to the internal leaflet of Bowman's capsule, and the squamous cell layer to the external leaflet. The moundlike swelling covered by podocytes is considered to represent a stage of possible evagination of the tufts of glomerular capillaries.There was no evidence of an opening of the urinary tubule in the cyst wall.

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“…Renal cystic diseases constitute a heterogenous group of hereditary, acquired and developmental disorders. Clinical symptoms of renal disease depend on the degree of involvement of the kidneys [16,17] and the widespread reduction in the functional kidney mass will usually lead to renal failure. In humans, PKD is an important cause of morbidity and mortality, being more common than other significant hereditary disorders such as sickle cell anemia, hemophilia, Huntington's chorea, and cystic fibrosis.…”

Section: Introductionmentioning

confidence: 99%

The First Report of Clinical and Pathological Studies of Polycystic Kidney Disease in a Herrik Lamb in the Middle East

Akbarī¹,

Javanbakht²,

Hobbenaghi³

2012

J Bacteriol Parasitol

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In April 2012, a 1-week-old female lamb was presented for evaluation to the field service at the Teaching Hospital Center, University of Urmia School of Veterinary Medicine with a history of progressive bilateral abdominal distention since birth. Two days after birth, the animal had mental dullness, a poor growth rate comparable to a twin, and progressive bilateral abdominal distension. On physical examination, the animal was in poor body condition and had a mass palpable in the cranial ventral abdomen (The abdomen was tight, round, and painful on palpation) and also lamb was bright, low awareness and responsive. Temperature (37°C), pulse (154 beats per minute), and respiration (55 breaths per minute) and weighing 3.5 kg were elevated. Histopathological examinations revealed that bilaterally enlarged kidneys were characterized by renal tubules at all levels of the nephron unit and extended into the cranial ventral abdomen. Glomeruli were sporadic, small and often hypoplastic or atrophic, located within a dilated Bowman's capsule. Renal cysts were usually bilateral, occurred in cortex and medulla and varied from less than 0.5 mm to over 5 mm in diameter. Cysts were lined by epithelial cells of nephron origin. Macroscopic and microscopic studies were similar to autosomal recessive polycystic kidney disease in humans and to previous reports of juvenile polycystic disorders in several animal species. Consequently, a polycystic kidney disease was diagnosed in Herrik lamb.

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Glomerular Cysts<subtitle>An Unusual Variety of "Polycystic Kidneys":</subtitle><subtitle>Report of Two Cases</subtitle>

Cited by 10 publications

References 8 publications

Morphogenesis of Glomerular Cysts in Renal Dysplasia

Morphogenesis of Glomerular Cysts in Renal Dysplasia

Scanning and transmission electron microscopy of cysts in the renal cortex of the macaque monkey.

The First Report of Clinical and Pathological Studies of Polycystic Kidney Disease in a Herrik Lamb in the Middle East

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