Glomerular Filtration Rate Determined in Conjunction with Routine Renal Scanning

Blue, Peter W.; Jackson, John H.; Ghaed, Nasser

doi:10.1148/radiology.156.2.553-a

Cited by 2 publications

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“…The mean GFR value measured with the Gate's method was 110.8 ± 21.3 (ml/min) and with the DPSM was 106.2 ± 24.0 (ml/min). GFR value obtained by Gate's method is 4.74 (ml/min) higher than the DPSM, which is similar to some studies of foreign authors [6].…”

Section: Resultssupporting

confidence: 89%

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Comparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method a

Dung

Ngoc

Phương

et al. 2021

YDLS

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Glomerular filtration rate (GFR) is an important indicator of renal function. Several methods have been applied to calculate GFR in clinical exams. In this study, we evaluated and compared between radionuclide plasma sampling methods (double blood samples, in vitro methods) and in vivo Gate’s method using 99mTc-diethylene triamine penta-acetic acid (99mTc-DTPA) renography. Subejct and method: 42 patients were participated in this study, including 12 patients with obstructive uropathy (group 1) and 30 renal donors (group 2). The administered doses were in a range of 5 – 7mCi. Then, scintigraphy was performed simultaneously after injection, and GFR was calculated by Gate’s method. Blood samples were collected at 60 mins and 120 mins post-injection, which were counted by a thyroid uptake system, and GFR results were determined using a double plasma sample (DPSM) method. Result: The mean GFRs calculated by renography in groups 1 and 2 were 85.8 ± 16.2 (ml/min) and 118.9 ± 13.9 (ml/min), respectively. Meanwhile, using the in vitro DPSM, the mean GFRs in group 1 and 2 were 73.8 ± 15.4 (ml/min) and 117.0 ± 13.0 (ml/min) respectively. They showed a high correlation between the two methods in the two groups (r = 0.86 and 0.71, respectively). Conclusion: Renography is a simple technique but considered inaccurate for determination of GFR. However, in vitro DPSM is rarely used in Vietnam. In this study, Gate’s method corresponded well with plasma sampling method and tended to overestimate the glomerular filtration rate.

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Section: Resultssupporting

confidence: 89%

“…Region of interests (ROIs) for each kidney, cortex region, background, and aorta were manually drawn and the time-activity curve was generated by xeleris software (GE, USA). GFR was calculated automatically according to the Gate's algorithm [6] and was normalized for a body surface area (BSA) of 1.73m 2 .…”

Section: Preparation Of Radiopharmaceuticalmentioning

confidence: 99%

Comparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method a

Dung

Ngoc

Phương

et al. 2021

YDLS

View full text Add to dashboard Cite

show abstract

“…The mean GFR value measured with the Gate's method was 110.8 ± 21.3 (ml/min) and with the DPSM was 106.2 ± 24.0 (ml/min). GFR value obtained by Gate's method was 4.74 (ml/min) higher than the DPSM, which was similar to some studies of foreign authors [6].…”

Section: Discussionsupporting

confidence: 90%

“…Region of interests (ROIs) for each kidney, cortex region, background, and aorta were manually drawn and the time-activity curve was generated by Xeleris software (GE, USA). GFR was calculated automatically according to the Gate's algorithm [6] and was normalized for a body surface area (BSA) of 1.73 m2.…”

Section: Renal Scintigraphy (Gate's Method)mentioning

confidence: 99%

Comparison of Two Methods for Estimation of Glomerular Filtration Rate: Double Plasma Sampling Method and Renography with 99mTc-DTPA

Thi Kim Dung,

Thi Phuong,

Van Thuyet

et al. 2021

MPS

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: Glomerular filtration rate (GFR) is a crucial metric that is widely used to evaluate kidney function. A method with high accuracy to estimate GFR is renal scintigraphy using radiopharmaceutical 99m-technetium diethylenetriamine pentaacetic acid (99mTc-DTPA) in SPECT (single-photon emission tomography) system. In addition, there is another method, the double plasma sampling method (DPSM) using the same radiopharmaceutical to determine GFR. This study aims to evaluate and compare GFR results collected from 42 patients by the two methods. The result indicates that the two methods have a high correlation with r = 0.857 and r = 0.711 (p<0.05), respectively in the two patient groups. Therefore, DPSM shows a high possibility for clinical application in certain situations. Keywords: 99mTc-DTPA, glomerular filtration rate, renography. References [1] K. Itoh, Comparison of Methods for Determination of Glomerular Filtration Rate: Tc-99m-DTPA Renography, Predicted Creatinine Clearance Method and Plasma Sample Method, Annals of Nuclear Medicine, Vol. 17, No. 7, 2003, pp. 561-565, https://doi.org/10.1007/BF03006669.[2] J. O. Hernandez, A. R. Torres, F. C. Rodriguez, Comparison of Four Methods for Measuring Glomerular Filtration Rate by Inulin Clearance in Healthy Individuals and Patients with Renal Failure, Nefrologia, Vol. 30, No. 3, 2010, pp. 324-330, https://doi.org/10.3265/Nefrologia.pre2010.Mar.10238.[3] L. A. Stevens, A. S. Levey, Measured GFR as a Confirmatory Test for Estimated GFR, Journal of the American Society of Nephrology, Vol. 20, No. 11, 2009, pp. 2305-2313, https://doi.org/10.1681/asn.2009020171.[4] F. J. Hoek, F. A. Kemperman, R. T. Krediet, A Comparison Between Cystatin C, Plasma Creatinine and the Cockcroft And Gault Formula for the Estimation of Glomerular Filtration Rate, Nephrology Dialysis Transplantation, Vol. 18, No. 10, 2003, pp. 2024-2031, https://doi.org/10.1093/ndt/gfg349.[5] W. S. Watson, A Simple Method of Estimating Glomerular Filtration Rate, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 19, No. 9, 1992, pp. 827, https://doi.org/10.1007/bf00182829.[6] P. W. Blue, J. H. Jackson, N. Ghaed, Re: Glomerular Filtration Rate Determined in Conjunction with Routine Renal Scanning, Radiology, Vol. 156, No. 2, 1985, pp. 553, https://doi.org/10.1148/radiology.156.2.553-a.[7] G. F. Gates, Split Renal Function Testing Using 99m-Tc DTPA. A Rapid Technique for Determining Differential Glomerular Filtration, Clinical Nuclear Medicine, Vol. 8, No. 9, 1985, pp. 400-407, https://doi.org/10.1097/00003072-198309000-00003.[8] K. W. Tobis et al., Difference in Estimated GFR with Two Different Formulas in Elderly Individuals, International Urology and Nephrology, Vol. 38, No. 2, 2006, pp. 381-385, https://doi.org/10.1007/s11255-006-0065-7.[9] C. D. Russell et. Al., Measurement of Glomerular Filtration Rate: Single Injection Plasma Clearance Method Without Urine Collection, Journal of Nuclear Medicine, Vol. 26, No. 11, 1985, pp. 1243-1247.[10] M. J. Surma, A. Plachcinska, J. Kusmierek, Modification of a Two Blood Sample Method Used for Measurement of GFR with 99mTc-DTPA, Nuclear Medicine Review - Central & Eastern Europe, Vol. 21, No. 1, 2018, pp. 43-47, https://doi.org/10.5603/nmr.2018.0013.[11] J. S. Fleming et al., Guidelines for the Measurement of Glomerular Filtration Rate Using Plasma Sampling, Nuclear Medicine Communications, Vol. 25, No. 8, 2004, pp. 759-769, https://doi.org/10.1097/01.mnm.0000136715.71820.4a.[12] A. Piepsz et al., Guidelines for Glomerular Filtration Rate Determination in Children, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 28, No. 3, 2001, pp. BP31-BP36.

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Glomerular Filtration Rate Determined in Conjunction with Routine Renal Scanning

Cited by 2 publications

References 0 publications

Comparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method a

Comparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method and gates method for estimation of glomerular filtration rateComparison of double plasma sampling method a

Comparison of Two Methods for Estimation of Glomerular Filtration Rate: Double Plasma Sampling Method and Renography with 99mTc-DTPA

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