Glomerular filtration rate, effective renal bloodflow, and maximal tubular excretory capacity in infancy

West, Joseph R.; Smith, Homer W.; Chasis, Herbert

doi:10.1016/s0022-3476(48)80124-1

Cited by 154 publications

(51 citation statements)

References 12 publications

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“…The anatomical fact that throughout childhood, and particularly in infancy, the ratio of the renal cortex to the medulla is lower than in the adult (14) might lead us to expect a low G.F./TmPAH ratio. However, our figures do not substantiate such an expectation; an indication (5,(17)(18)(19). Since this may not be the best point of reference, we have also given the absolute values.…”

Section: Resultscontrasting

confidence: 67%

“…ratio persists through the second or third year and in some instances later. West and his group (5) have also shown that this ratio is high in most of their infants under two years of 5 Two infants in the group were studied on repeated occasions: B. K. at 10 and 55 days-of age, and E. D. at 22 and at 54 days of age. In both infants the TmPAH (absolute values) remained stationary over the interim period, while the G.F. increased slightly in B. K. and considerably in E. D. age and Barnett et al (6) in examining premature infants found the F.F.…”

Section: Resultsmentioning

confidence: 99%

“…Recently West et al (5) reported a study of renal function in infants during the first two years of life and Barnett et al (6), a study in premature infants. This present study was begun in 1945 to determine the rate of maturation of certain of the kidney functions from the newborn period through childhood.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Maturation of Renal Function in Childhood: Clearance Studies12

Rubin¹,

Bruck²,

Rapoport³

et al. 1949

J. Clin. Invest.

246

120

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Section: Resultscontrasting

confidence: 67%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Maturation of Renal Function in Childhood: Clearance Studies12

Rubin¹,

Bruck²,

Rapoport³

et al. 1949

J. Clin. Invest.

246

120

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show abstract

“…Differences may be due to age-divergent expression of metabolic enzymes and/or transport systems necessary for absorption or excretion. para-Aminohippurate, a classic substrate for the organic anion transport system, and penicillin, another Oat substrate, are excreted less efficiently by newborns than by adults (West et al, 1948;Barnett et al, 1949). Furthermore, in humans, the capacity to transport organic anions does not mature until 7 to 8 months of age (West et al, 1948).…”

Section: Buist and Klaassenmentioning

confidence: 99%

RAT AND MOUSE DIFFERENCES IN GENDER-PREDOMINANT EXPRESSION OF ORGANIC ANION TRANSPORTER (OAT1–3; SLC22A6–8) mRNA LEVELS

Buist

Klaassen²

2004

Drug Metabolism and Disposition

132

112

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ABSTRACT:Organic anion transporters (Oats) mediate the initial step of active renal excretion, specifically substrate uptake into proximal tubule cells. Despite extensive characterization of rat Oats, mouse Oat expression patterns are virtually unknown. This study was designed to identify basal expression patterns of mouse Oat1 (Slc22a6), Oat2 (Slc22a7), and Oat3 (Slc22a8) mRNA, compare these patterns with those in rat, and characterize postnatal development of mouse Oat mRNA. Tissues were collected from adult male and female 129J and C57BL/6 mice, and male and female C57BL/6 mice 0 to 40 days of age. Oat mRNA levels were determined by branched DNA signal amplification. Mouse Oat1 mRNA was primarily expressed in kidney of both strains, with male predominance. Mouse Oat2 mRNA levels were highest in kidney of both strains without gender predominance. In both strains, Oat3 mRNA was highest in kidney, and liver expression was male-predominant. However, only 129J mice had higher Oat3 mRNA levels in female kidney than in male kidney. During postnatal development, both Oat1 and Oat2 mRNA levels began to rise after 25 days of age. Oat3 mRNA levels rose gradually from birth through 40 days of age. Oat2 mRNA increased 30-fold during the first 40 days, whereas Oat1 and Oat3 increased about 2-fold. The most notable species differences in Oat mRNA expression were a lack of Oat2 female predominance in mouse kidney and a less dramatic Oat3 male predominance in mouse liver. With the exception of a significant species difference in Oat2 expression, many similarities were found between rat and mouse Oat mRNA levels.

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“…Desde los estudios preliminares de Barnett 26 se sabe que la velocidad de filtracion glomerular en el recien nacido es menor que en el adulto, aun cuando se efectue la correccion correspondiente por area de superficie corporal 7 . Estudios posteriores han estimado la velocidad de filtracion glomerular a traves de la depuracion de inulina 2 -27 y de creatinina 1 -4 -5 - 13 .…”

Section: Discusionunclassified

Función Renal en Recién Nacidos de Termino y Pretérmino Durante el Segundo Día de Vida

U¹,

H²,

C³

et al. 1986

Rev. chil. pediatr.

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Glomerular filtration rate (GFR) by means of creatinine clearence was measured in 42 newborn infants, whose gestational ages (GA) ranged from 26 to 41 weeks. Renal excretion of water, Na and K were also measured. A direct correlation was find between gestational age (GA) and creatinine clearence (r: 0.67). An inverse correlation ocurred between GA and Na fraccional excretion (r: -0.84), GA and plasma K concentration (r: -0.67). but no correlation was find among GA and K urinary excretion. Uiiiie's volume and water excretion were also inversely related to GA (r: 0.83 and r: -0.54 respectively). (Key words: Creatinine Cleaience. Glomerular filtration rate. Renal function. Term and preterm newborn infants. Water, Sodium, Potasium, excretion).El progresivo interes por el estudio de la funcion renal en el recien nacido de diferente edad gestacional y los cambios que sobre elia impone la vida extrauterina ha llevado, en los ultimos afios, a un conocimiento mas precise de la fisiologia del riflon en desarrollo.Las investigaciones realizadas, se han orientado fundamentalmente a evaluar la velocidad de filtracion glomerular y sus modificaciones en la vida postnatal 1 " 12 , asi como al estudio de algunas funciones del transporte de agua y electroHtOS 3 ' 4 ' 8 ' 9 -13-22.Lq avanzado hasta ahora, ha permitido un mejor enfoque terapeutico del recien nacido critico, especialmente del pretermino, contribuyendo a mejorar sustancialmente las tasas de morbimortalidad de este grupo.En el presente estudio, se analizan algunos de los parametros de funcion renal en recien nacidos normales de termino y pretermino antes de los dos di'as de vida, dada la falta de referencias nacionales sobre esta materia.

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Glomerular filtration rate, effective renal bloodflow, and maximal tubular excretory capacity in infancy

Cited by 154 publications

References 12 publications

Maturation of Renal Function in Childhood: Clearance Studies12

Maturation of Renal Function in Childhood: Clearance Studies12

RAT AND MOUSE DIFFERENCES IN GENDER-PREDOMINANT EXPRESSION OF ORGANIC ANION TRANSPORTER (OAT1–3; SLC22A6–8) mRNA LEVELS

Función Renal en Recién Nacidos de Termino y Pretérmino Durante el Segundo Día de Vida

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