Glomerular filtration rate in schoolgirls with covert bacteriuria.

Jones, Karen; Asscher, A. W.; Jones, Eleanor; Mattholie, Kevin; Leach, K. G.; Thomson, Graeme

doi:10.1136/bmj.285.6351.1307

Cited by 48 publications

(5 citation statements)

References 11 publications

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“…Carrier state of ESBL (+) strains was mainly associated with previous long-term stays in hospitals, which correlates with our findings [16, 30–33]. Treatment should be considered individually, because antibiotic therapy may promote antibiotic resistance and predispose to symptomatic infection [34, 35].…”

Section: Discussionsupporting

confidence: 83%

Frequency of infections caused by ESBL-producing bacteria in pediatric ward – single center five-year observation

Będzichowska¹,

Przekora²,

Stapińska-Syniec³

et al. 2019

aoms

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Introduction Infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) are a serious therapeutic and clinical problem. An increasing role of ESBL(+) pathogens is observed in both community- and hospital-acquired infections. The aim of the study was to assess the incidence and the risk factors for ESBL(+) bacteria infection in a pediatric ward during a 5-year period. Material and methods The medical documentation data of patients hospitalized in the Department of Pediatrics, Pediatric Nephrology and Allergology between 2011 and 2015 were subjected to a retrospective analysis. Cases of ESBL(+) bacterial infections were analyzed in detail. Results 0.57% (46) of all the hospitalizations (8015) during the 5-year observation period in our department were caused by ESBL (+) pathogens. It constituted 8.5% of all positive microbiological cultures obtained. The analysis revealed an increasing trend in the number of ESBL (+) infections throughout the observed period. 43.5% of patients were only asymptomatic carriers. In 71.7% urinary tract structural and functional abnormalities were present. 76.1% of patients had been hospitalized previously and 60.9% had undergone urinary tract invasive procedures. Conclusions The results confirm the rising trend of ESBL (+) infections during the observed period. ESBL (+) bacteria were isolated primarily in previously hospitalized children with particular reference to urinary tract invasive procedures during hospitalizations. Moreover, the study showed that patients with urogenital disorders and non-urinary chronic diseases are more susceptible to these priority pathogen infections.

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Section: Discussionsupporting

confidence: 83%

Frequency of infections caused by ESBL-producing bacteria in pediatric ward – single center five-year observation

Będzichowska¹,

Przekora²,

Stapińska-Syniec³

et al. 2019

aoms

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“…In addition, due to intrauterine VUR, increased intraluminal pressure develops in the urinary tract, with a consequent harmful effect on the developing metanephros [6][7][8]. During the initial diagnostic evaluation of children with VUR, scars are found in the renal cortex and especially in the poles in 30-50% of cases [3].…”

Section: Pathogenesismentioning

confidence: 99%

“…20% of those suffering from end-stage chronic renal failure are due to an adverse progression of chronic atrophic pyelonephritis [7]. In 37% of adults with IRR, regardless of whether there is an underlying VUR, renal function deteriorates, while in 14% of this population, end-stage chronic renal failure is developed [8]. IRR is one of the most important etiological factors for the development of chronic renal failure (CRF) both in childhood and adulthood.…”

Section: Prognosismentioning

confidence: 99%

Pathogenesis and prognosis of intrarenal reflux

2023

Folia Medica Cracoviensia

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Scar development in the children's renal cortex with vesicoureteral reflux (VUR) is one of the most important parameters of prognosis. It can develop regardless of the chosen treatment, even after the regression of VUR. The shape of the renal papillae, the ascending urinary tract infection, the greater than third-degree VUR, and finally the increased intra-calyceal pressure, induce the formation of renal scarring in the renal parenchyma. Renal scarring may complicate VUR independently of the therapeutic strategy (conservative or operative) and its regression. For restitution of this entity, many scientific terms have been used and the most common of them is intrarenal reflux (IRR). The effects of VUR on future renal function result from the limited ability of the affected kidney to grow (failure of renal growth) due to the existence of scars in the renal cortex, the worsening of these scars, or finally the creation of new scars. With the present study, we intend to clarify the etiology and the pathophysiology of IRR and the relation of VUR prognosis to newer biomarkers such as N-acetyl-beta-glycosaminidase, beta-2 microglobulin, Pentraxin-3 and Liver-type fatty-acid-binding protein.

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“…An isolated positive urine culture can be found in children without symptoms (asymptomatic bacteriuria) and should not be treated, because antibiotics may promote symptomatic disease and antibiotic resistance and do not confer any longterm benefit. 4,5 Cystitis occurs when infection is limited to the urethra and bladder; children present with localising symptoms, such as frequency, urgency, dysuria, cloudy urine and lower abdominal discomfort. Pyelonephritis is almost always associated with fever, 6 except in some young infants.…”

Section: Frequency and Clinical Presentationmentioning

confidence: 99%

Diagnosis and management of urinary tract infection in children

Williams

Hodson

Isaacs

et al. 2010

J Paediatrics Child Health

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A young child presents to their primary health provider with fever and irritability. How likely is a urinary tract infection? How should a urine sample be collected? How accurate are urinary dipsticks and microscopy compared with culture for the diagnosis? What route and type of antibiotics should be used? What imaging is indicated? Diagnosing and treating children with urinary tract infection presents many questions. This review summarises the most relevant recent primary studies, systematic reviews and guidelines.

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Glomerular filtration rate in schoolgirls with covert bacteriuria.

Cited by 48 publications

References 11 publications

Frequency of infections caused by ESBL-producing bacteria in pediatric ward – single center five-year observation

Frequency of infections caused by ESBL-producing bacteria in pediatric ward – single center five-year observation

Pathogenesis and prognosis of intrarenal reflux

Diagnosis and management of urinary tract infection in children

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