1997
DOI: 10.1159/000190225
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Glomerular ICAM-1 Expression Related to Circulating TNF-α in Human Glomerulonephritis

Abstract: To clarify the in vivo involvement of cellular adhesion molecules and cytokines in human glomerulonephritis, we have investigated the glomerular and interstitial expression of intercellular adhesion molecule 1 (ICAM-1) in 69 kidney biopsy specimens by immunohistochemical methods and its correlation with serum bioactive tumor necrosis factor alpha (TNF-α) and soluble ICAM-1 (sICAM-1) levels in 43 cases. In normal controls, glomerular ICAM-1 expression and serum TNF-α and sICAM-1 levels showed a mean score of 1.… Show more

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Cited by 38 publications
(24 citation statements)
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“…In addition, the elevated serum level of tumor necrosis factor-α (TNF-α; 218.8 pg/ml) was decreased to 36.7 pg/ml, detected by ELISA as previously described. 8 We found that in 13 other patients with membranous nephropathy, urinary levels of IL-8 were below detectable levels, and urinary MCAF/MCP-1 and serum TNF-α levels were not as high (4.0 Ϯ 0.1 pg/mg · creatinine and 2.7 Ϯ 2.5 pg/ml, respectively), as in the patient described. She has received prednisolone 10 mg for maintenance every other day and the proteinuria has never recurred.…”
supporting
confidence: 41%
“…In addition, the elevated serum level of tumor necrosis factor-α (TNF-α; 218.8 pg/ml) was decreased to 36.7 pg/ml, detected by ELISA as previously described. 8 We found that in 13 other patients with membranous nephropathy, urinary levels of IL-8 were below detectable levels, and urinary MCAF/MCP-1 and serum TNF-α levels were not as high (4.0 Ϯ 0.1 pg/mg · creatinine and 2.7 Ϯ 2.5 pg/ml, respectively), as in the patient described. She has received prednisolone 10 mg for maintenance every other day and the proteinuria has never recurred.…”
supporting
confidence: 41%
“…ICAM-1 expression is induced by INF-␥ (45), reactive oxygen species (ROS) (46), and IL-1 (47). ICAM-1 is widely expressed in glomerular and interstitial areas in GN (48,49) and was also prominently expressed in this murine model of GN. Induction of ICAM-1 expression in GN was significantly decreased in TNFϪ/Ϫ mice, this corresponding with a significant reduction of glomerular and interstitial inflammatory cells.…”
Section: Discussionmentioning
confidence: 99%
“…Complement inhibition with sCrry in Crry transgenic mice and with Crry-Ig given as a recombinant protein had similar effects, with Crry-Ig consistently greater than sCrry (i.e., normalizing expression toward MRL ϩ/ϩ animals). TNF signaling through its TNFR1 has been shown to modulate the expression of iNOS and ICAM-1, which, in turn, can mediate inflammation and tissue damage (41). The expression of both iNOS and ICAM-1 was increased in MRL/lpr mouse brains compared with that in MRL ϩ/ϩ controls.…”
Section: Increased Expression Of Tnfr1 Inos and Icam-1 In Brains Ofmentioning
confidence: 99%