Glomerular Lesions in a Strain of Genetically Diabetic Mice

Abstract

GLOMERULAR LESIONS IN MICEdepressing PIF production by the hypothalamus (10). Apparently when the two lower doses of estradiol were injected, the action of the ME implant on AP prolactin predominated. However, the largest dose of estradiol given, lOpg, was able to completely counteract the effect of the ME prolactin implant on A P prolactin levels. This dose of estradiol may have acted both at the AP and hypothalamic levels. It is of interest that AP weight was equally increased by the 10-pg dose of estradiol in both the control and ME prolactin implanted rats.Several workers have reported on estrogen uptake by the hypothalamus and AP. Eisenfeld and Axelrod (11) observed that administered estradiol--H was approximately 5 times as concentrated in hypothalamic tissue and approximately 60 times as concentrated in AP tissue as in plasma. This may indicate a specific affinity by the AP and hypothalamus for estrogen. I t would be of interest to determine to what extent uptake of estrogen by these two tissues may be modified by an ME implant of prolactin. The present findings, as well as the observation that high circulating levels of prolactin can depress A P prolactin levels in rats ( 1 2 ) , suggest that circulating levels of prolactin may normally alter the actions of estrogen on the AP and hypothalamus. Summary.A median eminence implant of prolactin significantly lowered anterior pituitary prolactin content and concentration in female rats. Injection of 1.0 pg of estradiol benzoate daily for 5 days was unable to counteract this action of the ME implant of pro-lactin, whereas 5 pg was only Partially effective. However, injection of 10.0 pg of estradi-01 benzoate daily was as effective in increasing anterior pituitary prolactin levels in the presence its in the absence of an ME implant of prolactin. These results suggest that circulating levels of prolactin, by acting on the hypothalamus, may be able to modify the action of estrogen in promoting prolactin secretion.Glomerular lesions, similar to those found in human diabetes mellitus were observed in nonobese, genetically determined, spontaneously diabetic mice (1). The lesions were not found in pen-bred Swiss albino control ani-mals under the same laboratory conditions. The hereditary diabetic mice of the KR

The kidneys of NZB/B1, NZO/B1, NZC/B1 and NZY/B1 mice

“…Some of the differences in the reported findings relating to the NZB strain may be due to divergence in substrains, many of which have been separated from the original line for a considerable time. In the NZO strain metabolic characteristics possibly play a part in accentuating the renal lesions (Treser et al, 1968). Variations in environment can also exert a strong influence.…”

Glomerular basement membrane: biosynthesis and chemical composition in the streptozotocin diabetic rat.

“…This lesionl, first described by Kimmelstiel and Wilson (5), represents the most specific diabetic microvascular lesion, althouglh diffuse thickening of the glomerular basement membrane (GBM)' occurs with equal or greater frequency (6,7). Glomerular lesions resembling those seen in human diabetes have also been described in experimental animals with both genetic (8,9) and experimental diabetes (10)(11)(12)(13) suggesting that environmental factors may play a role in their pathogenesis. For example.…”

Hyaline Glomerulopathy in B6C3F1 Mice

“…Hyaline glomerulopathy; ultrastructure; lamellae; kidney; mouse Hyaline glomerulopathy, also known as glomerulosclerosis (7,8,12,16,20) or glomerulonephritis (1 1 , 13,14,17), is a spontaneous disease of undetermined etiology that occurs sporadically in various strains of aging mice. The pathogenesis of this condition'is uncertain, but based on the ultrastructural and immunocytochemical characteristics, it is widely regarded as being of an immune origin.…”