This paper demonstrates the advantages of using the computational fluid dynamics for plant operations or strategic investment decisions.To estimate an optimized geometric design of a tundish with increased steel volume, computational fluid dynamics can help reduce numerous and cost-intensive operational trials. The results concerning the separation of alumina-particles based on a mode of operation with one strand were numerically comprehended and qualitatively confirmed. For this purpose, the particle trajectories of the 50 IJm Al20 3-particles were calculated by means of the Euler-Lagrange model. Based on this model an optimized tundish design and tundish inserts were developed.

Glomerulosclerosis was found in 47% of 64 nonobese genetically "diabetic" KK mice. The changes consisted of a progressive increase in mesangial matrix and cells forming diffuse lesions. Nodular-type lesions,

GLOMERULAR LESIONS IN MICEdepressing PIF production by the hypothalamus (10). Apparently when the two lower doses of estradiol were injected, the action of the ME implant on AP prolactin predominated. However, the largest dose of estradiol given, lOpg, was able to completely counteract the effect of the ME prolactin implant on A P prolactin levels. This dose of estradiol may have acted both at the AP and hypothalamic levels. It is of interest that AP weight was equally increased by the 10-pg dose of estradiol in both the control and ME prolactin implanted rats.Several workers have reported on estrogen uptake by the hypothalamus and AP. Eisenfeld and Axelrod (11) observed that administered estradiol--H was approximately 5 times as concentrated in hypothalamic tissue and approximately 60 times as concentrated in AP tissue as in plasma. This may indicate a specific affinity by the AP and hypothalamus for estrogen. I t would be of interest to determine to what extent uptake of estrogen by these two tissues may be modified by an ME implant of prolactin. The present findings, as well as the observation that high circulating levels of prolactin can depress A P prolactin levels in rats ( 1 2 ) , suggest that circulating levels of prolactin may normally alter the actions of estrogen on the AP and hypothalamus. Summary.A median eminence implant of prolactin significantly lowered anterior pituitary prolactin content and concentration in female rats. Injection of 1.0 pg of estradiol benzoate daily for 5 days was unable to counteract this action of the ME implant of pro-lactin, whereas 5 pg was only Partially effective. However, injection of 10.0 pg of estradi-01 benzoate daily was as effective in increasing anterior pituitary prolactin levels in the presence its in the absence of an ME implant of prolactin. These results suggest that circulating levels of prolactin, by acting on the hypothalamus, may be able to modify the action of estrogen in promoting prolactin secretion.Glomerular lesions, similar to those found in human diabetes mellitus were observed in nonobese, genetically determined, spontaneously diabetic mice (1). The lesions were not found in pen-bred Swiss albino control ani-mals under the same laboratory conditions. The hereditary diabetic mice of the KR

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