Glomeruloid reactive angioendotheliomatosis in a woman with systemic lupus erythematosus and antiphospholipid syndrome mimicking reticular erythematous mucinosis

Ferreli, Caterina; Atzori, Laura; Rongioletti, Franco

doi:10.1016/j.jdcr.2020.12.012

Cited by 4 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, the gold standard for clinical diagnosis of APS is APL, whose positive rate is 0.999%–4.89% in the healthy population and 5.59%, 9.87%, 10.98%, and 16.95% in patients with pathological pregnancy, venous thromboembolism, myocardial infarction, and stroke, respectively, according to Massimo et al [ 5 ], indicating that it may be involved in the occurrence of related diseases. APLs are autoimmune antibodies that act on phospholipid-binding proteins, phospholipids, or their complexes, recognize and bind with phospholipid-binding proteins on platelets and endothelial cell membranes, and are mainly composed of anti-beta 2-glycoprotein I antibody (anti- β 2-GPI), anti-cardiolipin antibody (ACL), and lupus anticoagulant (LA) [ 6 ]. LA is a heterogeneous immunoglobulin that mainly interferes with the phospholipid-dependent coagulation process and prolongs the clotting time.…”

Section: Introductionmentioning

confidence: 99%

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Ding

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To investigate the application value of combined detection of anti-beta 2-glycoprotein I antibody (anti-β2-GPI), anti-cardiolipin antibody (ACL), and lupus anticoagulant (LA) in the diagnosis of patients with antiphospholipid syndrome (APS). Methods. 30 APS patients in our hospital between Jan. 2020 and Jan. 2021 were chosen as the experimental group, and 30 healthy persons with normal physical examination during the same period were selected as the control group The anti-β2-GPI and ACL indexes of both groups were detected by enzyme-linked immunosorbent assay (ELISA), with the LA levels tested by modified dilute Russell’s viper venom time (dRVVT) and LA ratio calculated. The diagnostic efficacy of single detection and combined detection was analyzed by plotting the receiver operating characteristic (ROC) curve. Results. The serum indexes in the experimental group were remarkably higher than those in the control group ( P < 0.001 ). ROC curve analysis suggested that in the diagnosis of APS, the area under the ROC curve by detecting anti-β2-GPI, ACL, LA ratio alone and simultaneously were 0.517, 0.583, 0.683, and 0.817 respectively, and the combined detection of the three had remarkably higher sensitivity and specificity than those of each single detection. Conclusion. The indexes of anti-β2-GPI, ACL, and LA ratio were highly expressed in APS patients, and the combined detection of the three has high diagnostic value and can effectively screen and assist the diagnosis of APS.

show abstract

Section: Introductionmentioning

confidence: 99%

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Ding

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…1 Variants of CRA are often associated with chronic infection and systemic disease and include reactive angioendotheliomatosis (RAE), glomeruloid angioendotheliomatosis, intravascular histiocytosis, acroangiodermatitis (pseudo-Kaposi sarcoma), diffuse dermal angiomatosis, and angiopericytomatosis. [1][2][3][4][5] Recent cases, however, suggest that these entities may overlap clinically and may not represent distinct forms of CRA. 6,7 The clinical appearance of CRA is nondistinctive and may range from widely distributed erythematous macules and ecchymoses to purpuric papules, nodules, and plaques, with a tendency to affect the limbs.…”

Section: Discussionmentioning

confidence: 99%

“…8 Several cases of RAE have been connected with antiphospholipid antibody syndrome and adverse drug reaction. 4,[9][10][11][12] Furthermore, RAE has been observed in adenopathy and extensive skin patch overlying a plasmacytoma syndrome, an early manifestation of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes syndrome, which rapidly progresses without treatment and can become life-threatening. 13,14 Angiomatosis with cryoproteins, also known as angiopericytomatosis, is an infrequently recognized variant of RAE with few published cases in the literature.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reticular Patches in a Patient With Multiple Myeloma: Answer

Chen

Vaughan

Matisko

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

“…Cold agglutinins, 24 lymphoma, 24 monoclonal gammopathy of unknown signifigance, 25 antiphospholipid syndrome 26,27 Angiomatosis with cryoproteins (angiopericytomatosis)…”

Section: Intraluminal Glomeruli-like Proliferation Of Capillariesmentioning

confidence: 99%

Cutaneous reactive angiomatosis associated with intravascular cryoprotein deposition as the presenting finding in a patient with underlying lymphoplasmacytic lymphoma: A case report and review of the literature

et al. 2021

View full text Add to dashboard Cite

Cutaneous reactive angiomatosis, a group of disorders defined by benign vascular proliferation, is associated with a number of systemic processes, including intravascular occlusion by cryoproteins. We report a case of a 64-year-old female patient who presented with a 1-year history of nontender petechiae of the bilateral arms and lower legs. Dermoscopic evaluation showed increased vascularity with a globular pattern. Over a period of months, her findings progressed to erythematous to violaceous plaques with admixed hypopigmented stellate scarring of the bilateral lower extremities, forearms, and lateral neck. Biopsy showed increased thin-walled, small dermal blood vessels with focal inter-anastamosis. Some vessels were occluded by eosinophilic globules suspicious for cryoprotein. Subsequent laboratory studies confirmed a diagnosis of type 1 cryoglobulinemia, prompting a bone marrow biopsy that revealed lymphoplasmacytic lymphoma. Herein, we report the fourth case of angiomatosis secondary to intravascular cryoproteins as the initial presentation of an underlying hematologic malignancy. We also present a review of the literature and emphasize the need for thorough initial workup and close and prolonged clinical monitoring for underlying systemic disease in these patients.

show abstract

Glomeruloid reactive angioendotheliomatosis in a woman with systemic lupus erythematosus and antiphospholipid syndrome mimicking reticular erythematous mucinosis

Cited by 4 publications

References 13 publications

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Reticular Patches in a Patient With Multiple Myeloma: Answer

Cutaneous reactive angiomatosis associated with intravascular cryoprotein deposition as the presenting finding in a patient with underlying lymphoplasmacytic lymphoma: A case report and review of the literature

Contact Info

Product

Resources

About