Glomerulonephritis in aleutian disease of mink: Histological and immunofluorescence studies

Pan, I. C.; Tsai, K. S.; Karstad, L.

doi:10.1002/path.1711010207

Cited by 28 publications

(12 citation statements)

References 19 publications

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“…Both general and specific mechanisms can be proposed to account for the increases in anti-DNA antibody that have been noted. In a general way, later triggering of self-perpetuating anti-DNA antibody could be the result of the constant buildup of toxic immune complexes (15,19) causing release of host debris, including cellular DNA. Recent results indicating absence of suppressor T cell function under conditions of treatment with anti-DNA-DNA complexes supports the idea that this immune complex may have unique properties (2).…”

Section: Discussionmentioning

confidence: 99%

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Autoimmunity in Aleutian disease: contribution of antiviral and anti-DNA antibody to hypergammaglobulinemia

Hahn¹,

Hahn²

1983

Infect Immun

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The contributions to Aleutian disease gammopathy of specific antiviral antibody and an autoimmune component, anti-DNA antibody, were studied with pastel ranch mink naturally infected with Aleutian disease virus. Specific antibody activities were determined by countercurrent immunoelectrophoresis and radioimmune assay, respectively. Gamma globulin levels (percent -y) were determined by serum electrophoresis. Within an infected mink population, it was possible to predict the level of gammopathy from measurement of the two antibody levels. For the mink serum samples used, there was better correlation between anti-DNA antibody levels and total serum immunoglobulin than between anti-Aleutian disease virus antibody titers and percent Y. With serum samples taken over a 2-week interval, significant increases were measured in anti-DNA antibody and percent y. Increases in anti-Aleutian disease virus titers during this period were not significant. The results suggest that the continuing increases in serum immunoglobulin in Aleutian disease virus-infected mink are due to both a specific antiviral response and an autoimmune response, as reflected in generation of anti-DNA antibody.Aleutian disease (AD) is an immunopathological disorder of mink induced by persistent infecon July 31, 2020 by guest http://iai.asm.org/ Downloaded from

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Section: Discussionmentioning

confidence: 99%

“…tion with AD virus (ADV) (16). The main lesions of the disease are caused by overproduction of immunoglobulin and formation and deposition of immune complexes (10,15,19). Antibody to viral antigens can be detected as early as 7 days (17) after infection.…”

mentioning

confidence: 99%

Autoimmunity in Aleutian disease: contribution of antiviral and anti-DNA antibody to hypergammaglobulinemia

Hahn¹,

Hahn²

1983

Infect Immun

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“…Observations on the macroscopic level lead to questions regarding whether there are differences between strains in permissiveness of cells which support viral replication. The distinction between the sites of viral replication and viral sequestration may be crucial since viruses are present in forms of active replication, latency, sequestration [16,17] or immune complexes [2,7,16,18]. To understand these disparate differences in the pathogenesis of PPV infection, the tissue tropisms and DNA replication profiles in Kresse and NADL-8 virus-inoculated late-term gestation swine fetuses were compared.…”

Section: Introductionmentioning

confidence: 99%

Tissue tropisms of porcine parvovirus in swine

Oraveerakul

Choi

Molitor

1993

Archives of Virology

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Late-term gestation swine fetuses, similar to adult animals, are able to effectively mount immune response and survive porcine parvovirus (PPV) infection. An exception to this is the Kresse strain of PPV, which causes fetal death in late-term gestation swine fetuses. In an effort to understand the basis for this profound difference in pathogenicity between Kresse strain and the prototype strain of PPV, NADL-8, studies were designed to examine potential difference in sites of replication and quantity of virus produced between Kresse and NADL-8 strains. In order to define the sites of viral replication or sites of viral sequestration in situ hybridization, using digoxigenin-labeled strand-specific oligonucleotide probes, was applied to detect the presence of either double stranded viral DNA (RF) or viral single stranded DNA in tissues of infected fetuses. The presence and the state of viral DNA was confirmed by Southern blot hybridization. Relative amounts of RF-DNA synthesis in each tissue was compared between the two virus strains. Virus replication appeared to be of comparable levels in the livers of both NADL-8 and Kresse infected swine fetuses. Differences between these strains were observed in the brain and spleen; RF-DNA was detected in the brain and spleens of Kresse infected fetuses but not in NADL-8 infected ones. These findings indicate that differences in DNA replication of the PPV strains in selective sites, as well as the quantity of virus produced, may explain the distinction in pathogenesis of these viruses.

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“…Antibody to ADV antigen appears 9 to 10 days after infection and reaches very high levels (1,4,9). ADV in the circulation of persistently infected mink is in the form of infectious virus-antibody complexes (8), and the arterial and glomerular lesions of Aleutian disease are caused by deposition of immune complexes with a subsequent inflammatory response (3,6,11).…”

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confidence: 99%

Pathogenesis of aleutian disease of mink: identification of nonpersistent infections

Larsen¹,

Porter²

1975

Infect Immun

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Aleutian disease virus usually produces a persistent infection and progressive immune complex disease in mink of the Aleutian genotype. Study of Aleutian disease virus infection in non-Aleutian mink showed that about one-quarter developed nonpersistent infections by the virus, and that the nonpersistence was not genetically determined by the host. The nonpersistently infected mink developed only a transient elevation of serum gamma globulin, and much lower specific Aleutian disease virus antibody titers than persistently infected mink. No lesions were found in the nonpersistently infected mink.

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Glomerulonephritis in aleutian disease of mink: Histological and immunofluorescence studies

Cited by 28 publications

References 19 publications

Autoimmunity in Aleutian disease: contribution of antiviral and anti-DNA antibody to hypergammaglobulinemia

Autoimmunity in Aleutian disease: contribution of antiviral and anti-DNA antibody to hypergammaglobulinemia

Tissue tropisms of porcine parvovirus in swine

Pathogenesis of aleutian disease of mink: identification of nonpersistent infections

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