Gloriosa superba L. (Flame Lily): Micropropagation and in Vitro Production of Colchicine

Finnie, J.F.; Staden, J. Van

doi:10.1007/978-3-642-57970-7_10

Cited by 18 publications

(13 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antimalarial activity of an ethanol leaf extract of Setaria megaphylla (Poaceae) was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections (Okokon et al 2007). The roots and tubers of Gloriosa superba, an ornamental climbing herb native of tropical Asia and Africa, have been used in traditional Indian medicine for the treatment of gout, in diseases of skin, and several other purposes (Finnie and Staden 1994). Choochote et al (2004) have reported colchicine-like activity in the hexane, dichloromethane, and methanol fractions of G. superba.…”

Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

View full text Add to dashboard Cite

Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of Plasmodium falciparum in culture using the fluorescence-based SYBR Green assay. Plant extracts showed moderate to good antiparasitic effects. Promising antiplasmodial activity was found in the extracts from two plants, Phyllanthus emblica leaf 50% inhibitory concentration (IC₅₀) 3D7: 7.25 μg/mL (ethyl acetate extract), 3.125 μg/mL (methanol extract), and Syzygium aromaticum flower bud, IC₅₀ 3D7:13 μg/mL, (ethyl acetate extract) and 6.25 μg/mL (methanol extract). Moderate activity (30-75 μg/mL) was found in the ethyl acetate and methanol extracts of Abrus precatorius (seed) and Gloriosa superba (leaf); leaf ethyl acetate extracts of Annona squamosa and flower of Musa paradisiaca. The above mentioned plant extracts were also found to be active against CQ-resistant strains (Dd2 and INDO). Cytotoxicity study with P. emblica leaf and S. aromaticum flower bud, extracts showed good therapeutic indices. These results demonstrate that leaf ethyl acetate and methanol extracts of P. emblica and flower bud extract of S. aromaticum may serve as antimalarial agents even in their crude form. The isolation of compounds from P. emblica and S. aromaticum seems to be of special interest for further antimalarial studies.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

View full text Add to dashboard Cite

show abstract

“…The roots and tubers of this plant have been used in traditional Indian medicine for the treatment of gout, rheumatic arthritis, diseases of the skin and liver, and several other purposes (Finnie and Staden, 1994). Since the detection of colchicine in Gloriosa (Clewer et al, 1915), a number of researchers have suggested that Gloriosa could serve as a commercial source of colchicine (Sarin et al, 1977;Srivastava and Chandra, 1977), as the colchicine content in the genera Colchicum has been reported to be lower than in Gloriosa (Bellet and Graignault, 1985).…”

Section: Introductionmentioning

confidence: 99%

“…Since the discovery of colchicine in Gloriosa, its commercial importance has increased as it has a higher content of colchicine than Colchicum (Yoschida, 1988a; Finnie & van Staden 1994). In horticultural practice, vegetative propagation of Gloriosa is commonly used but the growth is very low (Kranse 1986).…”

Section: Introductionmentioning

confidence: 99%

Improved Growth And Colchicine Concentration In <i>Gloriosa Superba</i> On Mycorrhizal Inoculation Supplemented With Phosphorus-Fertilizer

Pandey¹,

Malik²,

Dey³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: Gloriosa superba produces an array of alkaloids including colchicine, a compound of interest in the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which has shown anti-gout, anti-inflammatory, and anti-tumor activity. However, this promising compound remains expensive and Gloriosa superba is such a good source in global scale. Increase in yield of naturally occurring colchicine is an important area of investigation. Materials and Methods:The effects of inoculation by four arbuscular mycorrhizal (AM), fungi, Glomus mossae, Glomus fasciculatum, Gigaspora margarita and Gigaspora gilmorei either alone or supplemented with P-fertilizer, on colchicine concentration in Gloriosa superba were studied. The concentration of colchicine was determined by high-performance thin layer chromatography. Results: The four fungi significantly increased concentration of colchicine in the herb. Although there was significant increase in concentration of colchicine in non-mycorrhizal P-fertilized plants as compared to control, the extent of the increase was less compared to mycorrhizal plants grown with or without P-fertilization. This suggests that the increase in colchicine concentration may not be entirely attributed to enhanced P-nutrition and improved growth. Among the four AM fungi Glomus mossae was found to be best. The total colchicine content of plant (mg / plant) was significantly high in plants inoculated with Glomus mossae and 25 mg kg -1 phosphorus fertilizer (348.9 mg /plant) while the control contain least colchicine (177.87 mg / plant).

show abstract

“…In traditional Indian medicine, roots and tubers of G. superba have been used for the treatment of gout, rheumatic arthritis, diseases of skin and liver, and several other purposes (Finnie and Van Staden 1994 ) . Several researchers have suggested that Gloriosa could serve as a commercial source of colchicine (Sarin et al 1977 ;Srivastava and Chandra 1977 ) , since the detection of colchicine in Gloriosa (Clewer et al 1915 ) as the colchicine content in the genera Colchicum has been reported to be lower than in Gloriosa (Bellet and Gaignault 1985 ) .…”

Section: Gloriosa Superba Lmentioning

confidence: 99%

In Vitro Protocols for Ornamental Climbers

Shaheen

Shahzad

2015

Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers

View full text Add to dashboard Cite

Since the time immemorial, plants and plant parts thereof have been used as medicinal sources to cure various ailments and diseases. Recent era witnessed a great loss of this natural wealth because of its excessive use and overexploitation. Thus, it is the need of an hour to take immediate and possible measures for conserving such a great wealth. With the advent of biotechnological approaches, new vitas and horizons were broadened in every sphere of research including plant biotechnology that boosted during the present century and played a vital role in conserving ornamental plants, thus maintaining the depleting natural wealth under laboratory conditions in a short span of time. In vitro studies of several important ornamental climbers have been carried out by different workers, viz., Gloriosa superba , Ceropegia spp . , Allamanda , Passifl ora spp., etc. The present chapter deals with the detailed account of successful protocols developed through in vitro propagation of such elite germplasms.

show abstract

Gloriosa superba L. (Flame Lily): Micropropagation and in Vitro Production of Colchicine

Cited by 18 publications

References 35 publications

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Improved Growth And Colchicine Concentration In <i>Gloriosa Superba</i> On Mycorrhizal Inoculation Supplemented With Phosphorus-Fertilizer

In Vitro Protocols for Ornamental Climbers

Contact Info

Product

Resources

About