Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

Abstract

Glucagon-like peptide (GLP)-1 is released from the intestinal L cells in response tofood ingestion and stimulates insulin secretion from the pancreatic B cells, by binding to its specific receptor (GLP-1R), which is expressed on the pancreatic B cells in the mammalian pancreas. Previously, we demonstrated that chicken GLP-1R was expressed on the pancreatic D cells by using a specific antibody against chicken GLP-1R. In the present study, we compared the localization of GLP-1R in the pancreases of three avian species; white leghorn chicken, northern bobwhite, and common ostrich, using the double immunofluorescence technique. We found that the types of pancreatic islets in the northern bobwhite pancreas were similar to those found

Chicken Intestinal L Cells and Glucagon-like Peptide-1 Secretion

“…3) (Watanabe et al, 2014). Similar localization of cGLP1R has been observed in the pancreatic islets of other avian species, northern bobwhites, and common ostriches (Watanabe et al, 2018). Hall et al (1986) demonstrated a rapid increase in plasma glucose concentration after the intravenous injection of anti-somatostatin serum in domestic fowls.…”

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

“…Glucagon-like peptide-1 in chickens is mainly released from the intestinal epithelial endocrine L cells (including the jejunum and ileum) stimulated by processing of proglucagon, protein, and amino acid [ 142 ]. The GLP-1 receptor (GLP-1R) also expresses in the brain and liver in chickens [ 143 ].…”

“…In mammals, ucOCN also promotes insulin release mainly through two methods: one is directly affecting pancreatic β-cells, and another is indirectly simulating GLP-1 secretion from the small intestine and then GLP-1 activating pancreatic β-cells to secrete insulin [ 54 ]. However, unlike in mammals, the receptor of GLP-1 has been identified in chicken pancreatic D-cells secreting somatostatin rather than in pancreatic β-cells [ 142 , 144 ]. Overall, whether ucOCN affects GLP-1 in chickens is unclear.…”