Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter

Deng, Guifang; Lei, Qiucheng; Gao, Xuejin; Zhang, Yupeng; Zheng, Huazhen; Bi, Joffe; Wang, Xinying

doi:10.3389/fnut.2021.688715

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…The immunofluorescence experiment was followed the previous pattern with minor modifications ( 25 ). The sections (20 μm thick) were mounted on glass slides and washed for 15 min in PBS containing 0.2% Tween-20 (PBST).…”

Section: Methodsmentioning

confidence: 99%

Tilapia Skin Peptides Ameliorate Cyclophosphamide-Induced Anxiety- and Depression-Like Behavior via Improving Oxidative Stress, Neuroinflammation, Neuron Apoptosis, and Neurogenesis in Mice

Zhao

Yin

et al. 2022

Front. Nutr.

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Anxiety- and depression-like behavior following chemotherapy treatment occurs in cancer patients with high probability and no specific therapeutics are available for treatment and prevention of this complication. Here, tilapia skin peptides (TSP), a novel enzymatically hydrolyzed bioactive peptide mixture, obtained from tilapia (Oreochromis mossambicus) scraps, were studied on cyclophosphamide (CP)-induced anxiety- and depression-like behavior in mice. Mice were received intraperitoneal injection of CP for 2 weeks, while TSP was administered for 4 weeks. After the end of the animal experiment, behavioral, biochemical, and molecular tests were carried out. The mice decreased preference for sugar water, increased immobility time in the forced swimming and tail suspension test, and decreased travel distance in the open field test in the Model group, compared with the Control group. Abnormal changes in behavioral tests were significantly improved after the TSP treatment. Additionally, abnormalities on superoxide dismutase, malondialdehyde, glutathione peroxidase were rescued by administration of 1000 mg/kg/d TSP in mice than that of the Model group. TSP has normalized the expression of Iba-1 and the levels of TNF-α and IL-1β in the hippocampus of mice, which indicated that TSP could observably ameliorate neuroinflammatory response in the hippocampus of mice. TSP ameliorated the apoptosis of hippocampal neurons of CA1 and CA3 regions in the TSP group vs. the Model group. The number of doublecortin positive cells was drastically increased by administering 1000 mg/kg/d TSP in mice vs. the Model group. Furthermore, TSP reversed the Nrf2/HO-1 signaling pathway, BDNF/TrkB/CREB signaling pathway, and reduced the Bcl-2/Bax/caspase-3 apoptosis pathway. In conclusion, TSP could restore CP-induced anxiety- and depression-like behavior via improving oxidative stress, neuroinflammation, neuron apoptosis, and neurogenesis in mice hippocampus.

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Section: Methodsmentioning

confidence: 99%

Tilapia Skin Peptides Ameliorate Cyclophosphamide-Induced Anxiety- and Depression-Like Behavior via Improving Oxidative Stress, Neuroinflammation, Neuron Apoptosis, and Neurogenesis in Mice

Zhao

Yin

et al. 2022

Front. Nutr.

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“…To date, there is a lack of research on the direct role of IGF signaling in the normal function of PLCs or the interaction between the IGF system and autophagy in these colonic cells. In contrast, IGF-1 has been shown to be an important mediator of the tropic effect of glucagon-like peptide 2 (GLP-2), which attenuated small intestinal inflammation and improved the immune response of intestinal PCs in the total parenteral nutrition animal model of a study [ 185 ].…”

Section: Autophagy In Normal Large Intestine Epithelial Cells—implica...mentioning

confidence: 99%

Autophagy and the Insulin-like Growth Factor (IGF) System in Colonic Cells: Implications for Colorectal Neoplasia

Kasprzak

2023

IJMS

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Colorectal cancer (CRC) is one of the most common human malignancies worldwide. Along with apoptosis and inflammation, autophagy is one of three important mechanisms in CRC. The presence of autophagy/mitophagy in most normal mature intestinal epithelial cells has been confirmed, where it has mainly protective functions against reactive oxygen species (ROS)-induced DNA and protein damage. Autophagy regulates cell proliferation, metabolism, differentiation, secretion of mucins and/or anti-microbial peptides. Abnormal autophagy in intestinal epithelial cells leads to dysbiosis, a decline in local immunity and a decrease in cell secretory function. The insulin-like growth factor (IGF) signaling pathway plays an important role in colorectal carcinogenesis. This is evidenced by the biological activities of IGFs (IGF-1 and IGF-2), IGF-1 receptor type 1 (IGF-1R) and IGF-binding proteins (IGF BPs), which have been reported to regulate cell survival, proliferation, differentiation and apoptosis. Defects in autophagy are found in patients with metabolic syndrome (MetS), inflammatory bowel diseases (IBD) and CRC. In neoplastic cells, the IGF system modulates the autophagy process bidirectionally. In the current era of improving CRC therapies, it seems important to investigate the exact mechanisms not only of apoptosis, but also of autophagy in different populations of tumor microenvironment (TME) cells. The role of the IGF system in autophagy in normal as well as transformed colorectal cells still seems poorly understood. Hence, the aim of the review was to summarize the latest knowledge on the role of the IGF system in the molecular mechanisms of autophagy in the normal colon mucosa and in CRC, taking into account the cellular heterogeneity of the colonic and rectal epithelium.

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“…In addition to its protective and growth promoting roles in the intestine, GLP-2 exerts anti-inflammatory effects through multiple different mechanisms. For instance, GLP-2 dampened pro-inflammatory cytokine production in LPS-treated macrophages through inhibiting NF-κB activity and ERK phosphorylation [ 131 ] and reducing mucosal inflammatory responses [ 132 ] in mice, while in a model of obstructive jaundice in rats, GLP-2 reduced serum levels of TGF-β1, bilirubin, and endotoxin, which improved intestinal barrier function [ 133 ]. Interestingly, data from animal models of intestinal barrier dysfunction in mice, rats, and piglets underlines the importance and protective action of GLP-2 in inflammation-mediated intestine injuries [ 58 , 134 , 135 ].…”

Section: Glp-1 and Glp-2 As Regulators Of Intestine Integrity And Inf...mentioning

confidence: 99%

“…While parenteral nutrition remains the life-saving standard for nutrient delivery in patients with intestinal failure, serious complications may develop such as liver and intestinal mucosal barrier injury, inflammation, and bacterial translocation [ 137 , 138 ]. To further understand the role of GLP-2 to ameliorate parenteral nutrition-associated gut injury, using a mouse model of parenteral nutrition, Deng et al, showed that GLP-2 significantly suppressed the expression of pro-inflammatory cytokines TNF-a and IL-6 in the ileum and reduced serum levels of D-lactic acids and LPS [ 132 ].…”

Section: Glp-1 and Glp-2 As Regulators Of Intestine Integrity And Inf...mentioning

confidence: 99%

GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk

Abdalqadir

Adeli

2022

Microorganisms

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The intestine represents the body’s largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and basolateral surfaces and respond through endocrine and neuronal signaling to maintain metabolic homeostasis and energy expenditure. The intestine also harbours the largest population of microbes that interact with the host to maintain human health and diseases. Furthermore, the gut is known as the largest endocrine gland, secreting over 100 peptides and other molecules that act as signaling molecules to regulate human nutrition and physiology. Among these gut-derived hormones, glucagon-like peptide 1 (GLP-1) and -2 have received the most attention due to their critical role in intestinal function and food absorption as well as their application as key drug targets. In this review, we highlight the current state of the literature that has brought into light the importance of GLP-1 and GLP-2 in orchestrating intestine–microbiota–immune system crosstalk to maintain intestinal barrier integrity, inflammation, and metabolic homeostasis.

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Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter

Cited by 9 publications

References 42 publications

Tilapia Skin Peptides Ameliorate Cyclophosphamide-Induced Anxiety- and Depression-Like Behavior via Improving Oxidative Stress, Neuroinflammation, Neuron Apoptosis, and Neurogenesis in Mice

Tilapia Skin Peptides Ameliorate Cyclophosphamide-Induced Anxiety- and Depression-Like Behavior via Improving Oxidative Stress, Neuroinflammation, Neuron Apoptosis, and Neurogenesis in Mice

Autophagy and the Insulin-like Growth Factor (IGF) System in Colonic Cells: Implications for Colorectal Neoplasia

GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk

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