Glucaminium ionic liquid-functionalized stationary phase for the separation of nucleosides in hydrophilic interaction chromatography

Jiang, Qiong; Zhang, Mingliang; Wang, Xusheng; Guo, Yong; Qiu, Hongdeng; Zhang, Shusheng

doi:10.1007/s00216-015-8927-4

Cited by 19 publications

(6 citation statements)

References 39 publications

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“…For adenine, hypoxanthine and inosine, higher salt concentration weakened the electrostatic attraction between solutes and stationary phase, reducing the retention. For thymine, thymidine, uridine and cytidine, higher salt concentration reduced the solubility of some solutes on the water-enriched layer on the surface of stationary phase, which made the elution ability of the mobile phase to solutes decreased and retention increased [31,32].…”

Section: Investigation Of Retention Of Sil-2-mim In Hilic Modementioning

confidence: 99%

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Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Yang

Liu

Chen

et al. 2016

Journal of Chromatography A

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Section: Investigation Of Retention Of Sil-2-mim In Hilic Modementioning

confidence: 99%

“…The emergence of nitrogen could prove that immobilization on the silica surface was successful because of naked silica without nitrogen atoms. The bonding amount of Sil-2-MIm and Sil-1-MIm was 2.37 mol/m 2 and 2.25 mol/m 2 , respectively, according to the following equation [31][32][33]:…”

Section: Elemental Analysismentioning

confidence: 99%

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Yang

Liu

Chen

et al. 2016

Journal of Chromatography A

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“…R is the universal gas constant, T is column temperature in Kelvin, and ϕ is the phase ratio. As shown in Figure S6b, the retention time was reduced for increasing temperature, which also demonstrated that both adsorption and partitioning contribute to the retention mechanism. , …”

Section: Resultsmentioning

confidence: 71%

“…As shown in Figure S6b, the retention time was reduced for increasing temperature, which also demonstrated that both adsorption and partitioning contribute to the retention mechanism. 31,32 3.4. Chromatographic Performance of the MOF-808@ silica Composite.…”

Section: Effect Of Acetonitrile Content and Other Factors Onmentioning

confidence: 99%

Core–Shell Metal–Organic Frameworks as the Stationary Phase for Hydrophilic Interaction Liquid Chromatography

et al. 2020

ACS Appl. Nano Mater.

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A strategy based on in situ growth of a metal–organic framework composite material was proposed by introducing a sodium dodecyl benzenesulfonate (SDBS) group to increase the electrostatic interaction between the MOF ligand and silica. In this work, mesoporous silica spheres were first functionalized with a zirconium(IV)-based metal–organic framework material (MOF-808), which produced a core–shell particle (MOF-808@silica) as a hydrophilic interaction liquid chromatography (HILIC) stationary phase. The obtained material improves and enhances the selectivity and stability of the stationary phase in traditional MOF-based HILIC. A series of methods such as elemental analysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, and Brunauer–Emmett–Teller were used to confirm that MOF-808 was successfully modified onto silica. The relative standard deviation (RSD) of the retention time for stability with 120 h of continuous elution was found to range from 0.2% to 0.6%, and the RSD of the repeatability for 10 replicates of continuous elution was found to range from 0.1% to 0.3%. Furthermore, the column batch-to-batch reproducibility of the retention time was reproducible with an RSD of less than 2.2% depending on the analyte. The composite materials were found to be superior to most reported MOF-based stationary phases in terms of separation performance for various polar compounds, preparative reproducibility, and chromatographic stability. In short, MOF-808@silica composite material expands and improves the use of MOF materials as stationary phases in hydrophilic chromatography, revealing a method to prepare a MOF@silica composite that shows good performance when used for chromatographic analysis.

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“…RPLC has been employed to analyze melamine , but melamine was retained weakly because of the inherent hydrophilicity of melamine. As an alternative, a HILIC/IEC column has been explored to determine melamine . Therefore, the developed stationary phase was exploited to separate melamine in milk.…”

Section: Resultsmentioning

confidence: 99%

Controllable preparation of a hydrophilic/ion‐exchange mixed‐mode stationary phase by surface‐initiated atom transfer radical polymerization using a mixture of two functional monomers

Wang

Wei

2017

J of Separation Science

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Mixed-mode chromatographic stationary phases require functionalization with at least two functional groups to yield multiple interactions with analytes. Departing from reported methods, a mixture of two different monomers, glycidyl methacrylate and 2-dimethylaminoethylmethacrylate, was grafted onto the surface of silica by a one-step surface-initiated atom transfer radical polymerization to prepare a novel hydrophilic interaction/anion-exchange mixed-mode chromatographic stationary phase. The grafted amounts of functional groups were controlled via varying the ratio of monomers in the polymerization system. The influences of water content, salt concentration and pH in the mobile phase were investigated to illustrate the mixed interaction between the stationary phase and analytes. The retention of various solutes on three columns, especially acidic and basic solutes, showed an obvious dependence on the ratio of the two monomers in the polymerization system. The results indicated that the strategy proposed in this work was beneficial to develop various types of mixed-mode chromatographic stationary phases with adjustable selectivity to meet the needs of complex samples. Finally, the column was successfully employed in the isolation of melamine in liquid milk.

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Glucaminium ionic liquid-functionalized stationary phase for the separation of nucleosides in hydrophilic interaction chromatography

Cited by 19 publications

References 39 publications

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Core–Shell Metal–Organic Frameworks as the Stationary Phase for Hydrophilic Interaction Liquid Chromatography

Controllable preparation of a hydrophilic/ion‐exchange mixed‐mode stationary phase by surface‐initiated atom transfer radical polymerization using a mixture of two functional monomers

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