Glucocorticoid exposure and fracture risk in patients with new-onset rheumatoid arthritis

Abstract

Among younger, new-onset RA patients, fracture risk was significantly elevated at high levels of daily and cumulative dose, and was similar to unexposed patients by 12 months post-discontinuation.

Glucocorticoids in Management of Adult Rheumatoid Arthritis-Current Prescribing Practices and Perceptions of Physicians in India: GLUMAR Survey

“…Osteoporosis is a concern with use of steroids [21,22]. The risk can be tackled by implementing anti-osteoporotic strategies [23].…”

‘To treat or not to treat’: raising awareness on the effects of graft versus host disease drugs on musculoskeletal system

“…There are multiple side effects of the use of steroids such as immunosuppression, osteopenia, oedema, muscle atrophy, skin atrophy, and impaired wound healing (long-term use) [10]. Vertebral fractures because of increased osteocyte and osteoblast death by apoptosis and inhibition of osteoblast generation is another important feature which the rehabilitation specialists need to be aware of where a patient might complain of non-resolving persisting back pain [11]. Lastly, avascular necrosis is one of the most debilitating adverse effects, which typically happens within a couple of years of HCT [12].…”

It is the Best of Treatments, It is the Worst of Treatments: The Continuing Love‐Hate Relationship With Glucocorticoids in Rheumatoid Arthritis

“…Not surprisingly, these are also dose dependent. In a recently published retrospective analysis of newly diagnosed RA patients under the age of 65 years, doses of prednisone above 15 mg/day significantly increased the risk of fracture . This risk went back down to the level of unexposed patients at 12 months postdiscontinuation of the steroids.…”