2018
DOI: 10.3389/fmed.2018.00276
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Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway

Abstract: Background: Endothelial progenitor cells (EPCs) can be used to treat ischemic disease in cell-based therapy owing to their neovascularization potential. Glucocorticoids (GCs) have been widely used as strong anti-inflammatory reagents. However, despite their beneficial effects, side effects, such as impairing wound healing are commonly reported with GC-based therapy, and the effects of GC therapy on the wound healing function of EPCs are unclear.Methods: In this study, we investigated how GC treatment affects t… Show more

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Cited by 37 publications
(32 citation statements)
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References 68 publications
(98 reference statements)
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“…The cell apoptotic assay was performed as our previously described method [29]. A total number of 10 6 BCCs were seeded onto 10 cm dishes and cultured in the cultured medium until 80% confluency, and then cells were collected by treatment with trypsin and centrifuged at 1,000 rpm for 5 min.…”
Section: The Cell Apoptotic Assaymentioning
confidence: 99%
“…The cell apoptotic assay was performed as our previously described method [29]. A total number of 10 6 BCCs were seeded onto 10 cm dishes and cultured in the cultured medium until 80% confluency, and then cells were collected by treatment with trypsin and centrifuged at 1,000 rpm for 5 min.…”
Section: The Cell Apoptotic Assaymentioning
confidence: 99%
“…Glucocorticoids inhibit the re-uptake of excitotoxic glutamate from the synapse, impair calcium regulation and increase accumulation of oxygen radicals (Stein-Behrens et al 1992 ), thereby inducing excitotoxicity (Roy and Sapolsky 2003 ; Sorrells et al 2014 ) and compromising neuronal survival (Kaufer et al 2004 ). Other potential deleterious effects of glucocorticoids include impaired wound healing (Carolina et al 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…The PI3k-AKT pathway, a classical regulator of cell cycle and survival, has been implicated in ischemic conditions [11]. Moreover, activation of the AKT signaling pathway in endothelial-progenitor cells has been linked to wound healing and microvascular regeneration [54]. These findings suggest that the injection of BMSC secretomes from SCD patients could positively affect the local microenvironment, thusly facilitating the proliferation, recruitment and migration of resident endothelial cells in response to chemoattractants, which may reinforce skin regeneration and repair in conditions associated with impaired angiogenesis, e.g.…”
Section: Discussionmentioning
confidence: 99%