Glucocorticoid-loaded pH/ROS dual-responsive nanoparticles alleviate joint destruction by downregulating the NF-κB signaling pathway

Lu, Yanzhu; Zhou, Jiangling; Wang, Qianmei; Cai, Juan; Yu, Bo; Dai, Qijie; Bao, Ying; Chen, Rui; Zhang, Zhongrong; Zhang, Dinglin; Hou, Tianyong

doi:10.1016/j.actbio.2023.04.012

Cited by 12 publications

(12 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, FA-CsA NPs decreased the MPO activity to reduce the accumulation and infiltration of neutrophil in colon tissues, because the pH/ROS dual-responsive material can scavenge ROS and has anti-inflammatory activity. 23,43…”

Section: Discussionmentioning

confidence: 99%

“…pH/ROS dual responsive material was synthesized and characterized by our lab as previously reported method. 23 Cy5 carboxylic acid, 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy (polyethylene glycol)-2000 (DSPE-PEG 2000 ), and folic acid-conjugated 1,2-distearoyl-sn-glycero-3phosphoethanolamine-N-methoxy (polyethylene glycol)-3400 (DSPE-PEG 3400 -FA) were purchased from Xi'an Ruixi Corporation (Xi'an, China). Lecithin (refined) was supplied by Alfa Aesar (Ward Hill, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…CsAloaded pH/ROS dual-responsive NPs were prepared using a modified nanoprecipitation/self-assembly method. 23 The physicochemical properties of NPs are summarized in Table 1. As shown in Table 1, the sizes of blank NPs, CsA NPs, and FA-CsA NPs were 181.2 ± 1.9, 251.7 ± 5.2, and 232.0 ± 4.7 nm, respectively.…”

Section: Fabrication and Characterization Of Npsmentioning

confidence: 99%

“…Based on the microenvironment of inflammatory tissues (e.g., low pH value and high concentration of ROS), we previously prepared pH/ROS dual responsive material by using cinnamaldehyde and ROS-responsive moiety comodified α-cyclodextrin (α-CD). 23 Using this material as a carrier, pH/ ROS dual-responsive nanoparticles (NPs) were fabricated. These NPs can thoroughly release their payloads as well as scavenge ROS and release anti-inflammatory phytochemical cinnamaldehyde under pH or ROS conditions.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cyclosporine A-Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice

Li,

Wu,

et al. 2023

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a frequently occurring disease that seriously influences the patient’s quality of life. To decrease adverse effects and improve efficacy of therapeutics, nanomedicines have been widely used to treat IBD. However, how to thoroughly release payloads under an inflammatory microenvironment and synergistic therapy of IBD need to be further investigated. To address this issue, cyclosporine A (CsA)-loaded, folic acid (FA)-modified, pH and reactive oxygen species (ROS) dual-responsive nanoparticles (FA-CsA NPs) were fabricated using pH/ROS-responsive material as carrier. The prepared FA-CsA NPs had spherical shape and uniform size distribution and could smartly release their payloads under acid and/or ROS microenvironment. In vitro experiments demonstrated that FA-CsA NPs can be effectively internalized by activated macrophages, and the internalized NPs could down-regulate the expression of proinflammatory cytokines compared to free drug or nontargeted NPs. In vivo experiments verified that FA-CsA NPs significantly accumulated at inflammatory colon tissues and the accumulated NPs obviously improved the symptoms of colitis in mice without obvious adverse effects. In conclusion, our results provided a candidate for the targeted treatment of IBD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Fabrication and Characterization Of Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cyclosporine A-Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice

Li,

Wu,

et al. 2023

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

Bioactives and Biomaterial Construction for Modulating Osteoclast Activities

He,

Jiang,

Dong

2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Bone tissue constitutes 15–20% of human body weight and plays a crucial role in supporting the body, coordinating movement, regulating mineral homeostasis, and hematopoiesis. The maintenance of bone homeostasis relies on a delicate balance between osteoblasts and osteoclasts. Osteoclasts, as the exclusive “bone resorbers” in the human skeletal system, are of paramount significance yet often receive inadequate attention. When osteoclast activity becomes excessive, it frequently leads to various bone metabolic disorders, subsequently resulting in secondary bone injuries, such as fractures. This not only reduces life quality of patients, but also imposes a significant economic burden on society. In response to the pressing need for biomaterials in the treatment of osteoclast dysregulation, there is a surge of research and investigations aimed at osteoclast regulation. Promising progress is achieved in this domain. This review seeks to provide a comprehensive understanding of how to modulate osteoclast activities. It summarizes bioactive substances that influence osteoclasts and elucidates strategies for constructing related biomaterial systems. It offers practical insights and ideas for the development and application of biomaterials and tissue engineering, with the hope of guiding the clinical treatment of osteoclast‐related bone diseases using biomaterials in the future.

show abstract

Homology‐Activated Ultrasensitive Nanomedicines for Precise NIR‐II FL/MRI Imaging‐Guided “Knock‐On” Dynamic Therapy in Rheumatoid Arthritis

Dai,

Zhao,

Zheng

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Stimuli‐responsive nanomedicines represent a pivotal technology for in situ on‐demand drug release and offer multiple advantages over conventional drug delivery systems to combat rheumatoid arthritis (RA). However, the lack of sensitivity to a single‐stimuli source or the inability to synchronize multi‐stimuli responses can easily lead to challenges in achieving precise theranostics of RA. Herein, a homology‐activated ultrasensitive nanomedicines MnO2‐CQ4T‐GOx (MCG NMs) is designed for NIR‐II fluorescence (NIR‐II FL)/MRI imaging‐guided effective “knock‐on” dynamic anti‐RA therapy. Building upon the characteristics of the RA‐microenvironment (acidic pH, redox), the MCG NMs innovatively construct a MnO2‐Mn2+ reaction system, which can normalized activation sites. The ultrasensitive responsive degradation is achieved using the multi‐stimuli processes in the RA‐microenvironment, triggering release of functional small molecules (Mn2+ ions, GOx, and CQ4T‐BSA). The produced Mn2+ can exert Fenton‐like activity to generate highly toxic hydroxyl radical (•OH) from endogenous H2O2, thus providing the effective chemodynamic therapy (CDT). Moreover, the up‐regulation of H2O2 by GOx‐catalysis not only sensitizes the MnO2‐Mn2+ reaction system but also achieves self‐enhancing CDT efficacy. The NIR‐II FL quenching of CQ4T‐BSA in the aggregated state occurs in MCG NMs, which can be rapidly and precisely “turn on” via the MnO2‐Mn2+ reaction system. Meanwhile, the integration of activated Mn2+‐based MRI imaging has successfully developed an activatable dual‐modal imaging. Feedback imaging‐guided precise photodynamic therapy (PDT) of CQ4T‐BSA can achieve efficient “knock‐on” dynamic therapy for RA.This article is protected by copyright. All rights reserved

show abstract

Glucocorticoid-loaded pH/ROS dual-responsive nanoparticles alleviate joint destruction by downregulating the NF-κB signaling pathway

Cited by 12 publications

References 47 publications

Cyclosporine A-Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice

Cyclosporine A-Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice

Bioactives and Biomaterial Construction for Modulating Osteoclast Activities

Homology‐Activated Ultrasensitive Nanomedicines for Precise NIR‐II FL/MRI Imaging‐Guided “Knock‐On” Dynamic Therapy in Rheumatoid Arthritis

Contact Info

Product

Resources

About