1984
DOI: 10.1042/bj2200125
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Glucocorticoids and catecholamines as mediators of acute-phase proteins, especially rat α-macrofoetoprotein

Abstract: Adrenal hormones were studied as possible triggering substances of the synthesis of acute-phase reactants in rats. alpha-Macrofoetoprotein, which rises sharply in concentration during inflammation, was used to monitor the acute-phase reaction. In normal rats glucocorticoids and catecholamines induce alpha-macrofoetoprotein synthesis; glucocorticoids only increase alpha-macrofoetoprotein to moderate levels in plasma, but catecholamines enhance alpha-macrofoetoprotein synthesis to very high levels, comparable wi… Show more

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Cited by 57 publications
(17 citation statements)
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“…In rats, both cl,-acid glycoprotein and cc,-macroglobulin are sensitive 'acute-phase' reactants that have been employed to quantitate the 'acute-phase' response [33]. Since the molecularly-mobile carbohydrate moiety of a,-acid glycoprotein is predominantly responsible for the three NMR-detectable glycoprotein signals present in SEFT 'H spectra of rat plasma, further high field 'H-NMR studies are likely to be of much use in determining the biofluid concentrations of this glycoprotein in experimental models of inflammation employing these animals.…”
Section: Discussionmentioning
confidence: 99%
“…In rats, both cl,-acid glycoprotein and cc,-macroglobulin are sensitive 'acute-phase' reactants that have been employed to quantitate the 'acute-phase' response [33]. Since the molecularly-mobile carbohydrate moiety of a,-acid glycoprotein is predominantly responsible for the three NMR-detectable glycoprotein signals present in SEFT 'H spectra of rat plasma, further high field 'H-NMR studies are likely to be of much use in determining the biofluid concentrations of this glycoprotein in experimental models of inflammation employing these animals.…”
Section: Discussionmentioning
confidence: 99%
“…Kibler et al, 1964) and catecholamines (cf. Van Gool et al, 1984) were elevated. The high level of corticosterone at day 4 well correlated with enlarged adrenal glands and an associated hypertrophic/hyperplastic histological pattern.…”
Section: Humoral Mediatorsmentioning
confidence: 99%
“…Adrenal catecholamines have been demonstrated to be essential for the induction of many acute-phase proteins, a class of proteins whose plasma concentrations increase/decrease in response to inflammation (45). Differential expression of Ͼ 20 genes implicated in immunological processes was observed in adrenal glands from IUGR fetuses.…”
Section: Discussionmentioning
confidence: 93%