Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study

Thuzar, Moe; Law, W. Phillip; Ratnasingam, Jeyakantha; Jang, Choon‐Gon; Dimeski, Goce; Ho, Ken K. Y.

doi:10.1111/dom.13157

Cited by 50 publications

(72 citation statements)

References 53 publications

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“…In addition to thermoregulation, BAT plays a role in regulating energy and substrate metabolism after a meal . Energy production is stimulated by nutrient intake.…”

Section: Introductionmentioning

confidence: 99%

“…The postprandial increase in energy production comprises heat energy dissipated by BAT and the energy required for processing and storage of nutrients . We have recently reported that glucocorticoids inhibit postprandial BAT thermogenesis, resulting in the channelling of energy which would otherwise be dissipated as heat, towards lipid synthesis . If BAT thermogenesis is stimulated, the converse may occur.…”

Section: Introductionmentioning

confidence: 99%

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Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo‐controlled cross‐over study

Thuzar

Law

Dimeski

et al. 2018

Diabetes Obesity Metabolism

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MC antagonism enhanced human BAT function in response to cooling and to a meal during which lipid synthesis was suppressed. As postprandial EPR comprises energy dissipated as heat and energy required to store nutrients, the reduction in lipid synthesis during MC antagonism is a probable consequence of concurrent stimulation of BAT thermogenesis. The shift in energy usage from storage to heat dissipation indicates that MC antagonists may have therapeutic benefit for obesity.

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“…In addition to thermoregulation, BAT plays a role in regulating energy and substrate metabolism after a meal . Energy production is stimulated by nutrient intake.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo‐controlled cross‐over study

Thuzar

Law

Dimeski

et al. 2018

Diabetes Obesity Metabolism

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“…The first study to use IRT to estimate SST was performed in 2011 . Ten studies were then published between 2011 and 2016 , six in 2017 , six in 2018 , and one until April 2019 .…”

Section: Resultsmentioning

confidence: 99%

“…Cold exposure is the main activator of BAT in humans . Most, but not all, of the identified studies ( n = 18; 75%) included cooling protocols, although the duration, temperature, and the way of inducing cooling differed between studies (Figure ). Nine out of these eighteen studies used hands/feet immersion in cold water (temperature 10.8°C ± 8.7°C, duration: 6.1 ± 6.8 minutes) .…”

Section: Resultsmentioning

confidence: 99%

“…Sarasniemi et al compared IRT‐measured SST with the temperature of the supraclavicular depot as measured by MRS and observed a positive and significant correlation in lean adults but a negative correlation in adults with obesity. Moreover, Thuzar et al performed two independent studies in which they compared IRT‐measured SST against BAT 18 F‐FDG uptake as measured by a PET/CT scan on the same day, reporting a positive and significant association between them. In contrast, Law et al made the same kind of measurements on separate days and using different cold exposure times.…”

Section: Discussionmentioning

confidence: 99%

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Infrared Thermography for Estimating Supraclavicular Skin Temperature and BAT Activity in Humans: A Systematic Review

Jiménez-Pavón

Corral-Pérez

Sánchez‐Infantes

et al. 2019

Obesity

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Objective Brown adipose tissue (BAT) is a thermogenic tissue with potential as a therapeutic target in the treatment of obesity and related metabolic disorders. The most used technique for quantifying human BAT activity is the measurement of 18F‐fluorodeoxyglucose uptake via a positron emission tomography/computed tomography scan following exposure to cold. However, several studies have indicated the measurement of the supraclavicular skin temperature (SST) by infrared thermography (IRT) to be a less invasive alternative. This work reviews the state of the art of this latter method as a means of determining BAT activity in humans. Methods The data sources for this review were PubMed, Web of Science, and EBSCOhost (SPORTdiscus), and eligible studies were those conducted in humans. Results In most studies in which participants were first cooled, an increase in IRT‐measured SST was noted. However, only 5 of 24 such studies also involved a nuclear technique that confirmed increased activity in BAT, and only 2 took into account the thickness of the fat layer when measuring SST by IRT. Conclusions More work is needed to understand the involvement of tissues other than BAT in determining IRT‐measured SST; at present, IRT cannot determine whether any increase in SST is due to increased BAT activity.

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Aging of Brown and Beige/Brite Adipose Tissue

Graja

Gohlke

Schulz

2018

Handbook of Experimental Pharmacology

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Brown adipose tissue aging and the concomitant loss of thermogenic capacity have been linked to an inability to maintain normal energy homeostasis in late life. Similarly, the ability of white fat to convert into brite/beige adipose tissue declines. This may ultimately exacerbate the progression of age-related metabolic pathologies, such as insulin resistance and obesity. The depletion of all types of brown adipocytes during aging is well-established and has been described in rodent models as well as humans. We here review the available literature on the potential mechanisms leading to cell-autonomous and microenvironment-related aspects of brown adipocyte dysfunction. Among these, cellular senescence, mitochondrial impairment, and deteriorating changes to the local and endocrine microenvironments have been proposed. An important goal of aging research is to develop approaches that may not only extend life expectancy but also prolong health-span. These efforts may also be aimed at maintaining metabolic health throughout life by targeting brown adipocyte function.

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Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study

Cited by 50 publications

References 53 publications

Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo‐controlled cross‐over study

Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo‐controlled cross‐over study

Infrared Thermography for Estimating Supraclavicular Skin Temperature and BAT Activity in Humans: A Systematic Review

Aging of Brown and Beige/Brite Adipose Tissue

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