Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis

Clegg, Daniel O.; Reda, Domenic J.; Harris, Crystal L.; Klein, Marguerite; O'Dell, James Robert; Hooper, Michele; Bradley, John; Bingham, Clifton O.; Weisman, Michael H.; Jackson, Christopher; Lane, Nancy E.; Cush, John J.; Moreland, Larry W.; Schumacher, H. Ralph; Oddis, Chester V.; Wolfe, Frederick; Molitor, Jerry A.; Yocum, David E.; Schnitzer, Thomas J.; Fürst, Daniel E.; Sawitzke, Allen D.; Shi, Helen; Brandt, Kenneth D.; Moskowitz, Roland W.; Williams, H. James

doi:10.1056/nejmoa052771

Cited by 1,157 publications

(928 citation statements)

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“…The findings of this work, as well as those of de Biasi et al (2005) and Clegg et al (2006), contrast with other reports available in the literature attesting improvement in limb function associated with the use of chondroitin Group Table 6. Mean values of the circumference (cm) of the right (operated) and left (non-operated) limbs, at the height of the femorotibio-patellar joints, obtained from the T15 groups in the preoperative period and in the final clinical evaluation sulphate and glucosamine.…”

Section: Day 5 Day 10 Day 15contrasting

confidence: 98%

“…But the variation was not confirmed by the ANOVA with repeated measures, with no significant difference between the measurements of operated and non-operated dogs, regardless of group. Although Henrotin et al (2005) claim that the use of chondroitin sulfate and glucosamine as chondroprotectors promotes improvement of symptoms such as lameness and pain, in this study there was no significant difference between the treated and control groups regarding the degree of lameness and pain, which was also observed by Biasi et al (2005) in the treatment with 240 mg of chondroitin sulfate, subcutaneously, in dogs with unstable knees, and by Clegg et al (2006), when treated osteoarthritis in humans using the same substances.…”

Section: Day 5 Day 10 Day 15contrasting

confidence: 49%

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Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Eleotério

Borges

Pontes³

et al. 2012

Rev. Ceres

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RESUMO Sulfato de condroitina e glucosamina na reparação de defeitos osteocondrais em cães -análise clínico-radiográficaDentre os tratamentos propostos para a doença articular degenerativa (DAD), os nutracêuticos condroprotetores à base de sulfato de condroitina constituem uma terapia não invasiva que favorece a manuteção da saúde da cartilagem. Além de utilizados em humanos, foram também disponibilizados para uso veterinário administrados na forma de suplemento nutricional independentemente de prescrição, uma vez que possuem somente o registro do Serviço de Inspeção Federal, que não exige testes de eficácia e segurança. A falta desses testes pelo Ministério da Agricultura Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs -clinical-radiographic analysis 1Among the proposed treatments to repair lesions of degenerative joint disease (DJD), chondroprotective nutraceuticals composed by glucosamine and chondroitin sulfate are a non-invasive theraphy with properties that favors the health of the cartilage. Although used in human, it is also available for veterinary use with administration in the form of nutritional supplement independent of prescription, since they have registry only in the Inspection Service, which does not require safety and efficacy testing. The lack of such tests to prove efficacy and safety of veterinary medicines required by the Ministry of Agriculture and the lack of scientific studies proving its benefits raises doubts about the efficiency of the concentrations of such active substances. In this context, the objective of this study was to evaluate the efficacy of a veterinary chondroprotective nutraceutical based on chondroitin sulfate and glucosamine in the repair of osteochondral defects in lateral femoral condyle of 48 dogs, through clinical and radiographic analysis. The animals were divided into treatment group (TG) and control group (CG), so that only the TG received the nutraceutical every 24 hours at the rate recommended by the manufacturer. The results of the four treatment times (15, 30, 60 and 90 days) showed that the chondroprotective nutraceutical, in the rate, formulation and administration at the times used, did not improve clinical signs and radiologically did not influence in the repair process of the defects, since the treated and control groups showed similar radiographic findings at the end of the treatments.

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Section: Day 5 Day 10 Day 15contrasting

confidence: 98%

Section: Day 5 Day 10 Day 15contrasting

confidence: 49%

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Eleotério

Borges

Pontes³

et al. 2012

Rev. Ceres

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show abstract

“…cohosh [3], and glucosamine [4], and increasing reports of adverse effects of dietary supplements leading to product warnings, withdrawals, and bans, as in the cases of kava [5], Lipokinetix [6], and ephedra [7], respectively. It is difficult to properly ascertain the safety of dietary supplements without a standard and systematic approach to monitoring reports of adverse events.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplement adverse events: Report of a one-year poison center surveillance project

et al. 2008

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“…Furthermore, the decision to try analgesic therapy was often made on their own or on the advice of family or friends, suggesting that many may choose to disregard the advice of health professionals in favor of their own preferences or well-being (20). This is further evidenced by the large number of participants who started glucosamine, despite evidence of limited efficacy (21). However, a limitation to our approach was that precautions (hepatic dysfunction, alcohol use) and previous history of previous treatment failures with acetaminophen were not assessed to determine the influence of these factors on therapeutic selection by participants.…”

Section: Discussionmentioning

confidence: 99%

After patients are diagnosed with knee osteoarthritis, what do they do?

Grindrod

Marra

Colley

et al. 2010

Arthritis Care & Research

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Objective. To learn more about the health services and products that patients use after receiving a diagnosis of knee osteoarthritis (OA), as well as the trajectory of their health-related quality of life (HRQOL). Methods. Using a simple screening survey, community pharmacists identified 194 participants with previously undiagnosed knee OA. Of these participants, 190 were confirmed to have OA on further investigation. At baseline and 1, 3, and 6 months after diagnosis, a survey was administered to assess health services, product use, and HRQOL, including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Medical Outcomes Study Short Form 36 (SF-36) health survey, the Paper Adaptive Test (PAT-5D-QOL), and the Health Utilities Index Mark 3. Results. With a mean age of 63 years, participants were mostly women, white, and overweight. By 6 months, more than 90% of the participants had visited their family physician to discuss their OA, and more than 50% of participants took either prescription or nonprescription analgesics. In addition, three-quarters of the participants started exercising, one-third initiated activity aids, and one-third had started natural medicine products. At 6 months compared with baseline, significant improvements were seen in the SF-36 physical component summary (P ‫؍‬ 0.001) and bodily pain domain scores (P ‫؍‬ 0.02), the PAT-5D-QOL overall, pain, and usual daily activities scores (P < 0.001 for all), and the WOMAC total, pain, and function scores (P < 0.001 for all). Conclusion. Within 6 months of receiving a diagnosis of knee OA, participants made several lifestyle interventions, often without the advice of a health professional, and saw improvements in their pain and function.

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Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis

Abstract: TitleGlucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis Permalink https://escholarship.org/uc/item/7zw280cw Journal

Cited by 1,157 publications

References 21 publications

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Dietary supplement adverse events: Report of a one-year poison center surveillance project

After patients are diagnosed with knee osteoarthritis, what do they do?

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