Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants

Uitterlinden, E.J.; Koevoet, J. L. M.; Verkoelen, CF; Bierma-Zeinstra, S.; Jahr, Holger; Weinans, Harrie; Verhaar, Jan A N; Osch, G. van

doi:10.1186/1471-2474-9-120

Cited by 37 publications

(29 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, both passive and active range of motion of the knee improved significantly in participants who consumed MFGM1glucosamine, and there was a significant group-by-time interaction. Glucosamine has been reported to have a positive effect on the synthesis and degradation of cartilage (14-17) and a stimulatory effect on production of hyaluronic acid in the synovium (18). In a study performed in young athletes, 4 wk of glucosamine consumption improved the passive range of motion in injured knees (19).…”

Section: Discussionmentioning

confidence: 99%

Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Suzukamo

Ishimaru

Ochiai

et al. 2019

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Care of the musculoskeletal system, including the muscles, joints, and bones, is important for a healthy life expectancy in today's aging society. The aim of this randomized, double-blind, placebo-controlled study was to investigate the effect of consumption of milk-fat globule membrane (MFGM) and glucosamine on joint function and physical performance. Participants were healthy Japanese men and women, aged 60-74 y, with a history of mild knee or low back pain at rest. They were randomized to receive tablets containing MFGM 1.0 g1glucosamine 1.5 g or placebo tablets for 8 wk. We assessed passive range of motion, active range of motion (self-reported VAS score), JKOM and JLEQ, and physical performance. Data were available for analysis for 25 participants in the active treatment group and 28 in the placebo group. The active group showed significant improvements in passive range of motion at the knee and active range of motion at both the knee and low back. The active group also showed significant improvements in some physical performance, including obstacle walking speed and speed of ascending stairs. The findings of this study suggest that consumption of a combination of MFGM and glucosamine may improve joint function and physical performance.

show abstract

Section: Discussionmentioning

confidence: 99%

Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Suzukamo

Ishimaru

Ochiai

et al. 2019

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…These growth factors include platelet‐derived growth factor, transforming growth factor‐β, and insulin‐like growth factor, which have been found in vitro to promote the expression of type 1 and 3 collagen in tenocytes [18]. In additional in vitro studies, human osteoarthritic synovial tissue exposed to glucosamine and glucose produced increased levels of hyaluronic acid production [19].…”

Section: Regenerative Agents: Evidence Basementioning

confidence: 99%

Regenerative Injection Therapy for Osteoarthritis: Fundamental Concepts and Evidence‐Based Review

Vora

Borg‐Stein

Nguyen

2012

PM&R

View full text Add to dashboard Cite

Regenerative therapy involves the injection of a small volume of solution into multiple sites of painful ligament and tendon insertions (entheses) and adjacent joint spaces, with the goal of reducing pain and ostensibly promoting tissue repair and growth. Dextrose and platelet-rich plasma solutions have been shown to increase expression of growth factors in vivo and have shown promising clinical results in the treatment of tendinosus. In the treatment of osteoarthritis, small clinical trials and case series to date suggest safety, symptomatic improvement, and functional improvement at up to a year of follow-up; however, most of these studies are uncontrolled. Given the methodological limitations of clinical research on regenerative injections for osteoarthritis to date, this treatment should be considered only after execution of a comprehensive assessment and treatment plan, including optimization of biomechanics, weight loss, cardiovascular exercise, resistance training, and judicious use of more established topical, oral, and injectable medications.

show abstract

“…mine, thereby decreasing infl ammation, and become a viable option in prevention and rehabilitation of joint degenerative disease [ 3 ] . Moreover, it has been demonstrated that glucosamine has an anti-infl ammatory eff ect via the reduction of nuclear factor kappa beta induced by interleukin-1 (IL-1) in animal models [ 4 ] .…”

Section: Comparative Fasting Bioavailability and Pharmacokinetic Propmentioning

confidence: 99%

Comparative Fasting Bioavailability and Pharmacokinetic Properties of 2 Formulations of Glucosamine Hydrochloride in Healthy Chinese Adult Male Volunteers

Liu

Wang

et al. 2012

Arzneimittelforschung

View full text Add to dashboard Cite

Glucosamine (CAS 66-84-2) hydrochloride is an amino monosaccharide indicated for the treatment of arthrosis, especially osteoarthritis of the knee joint. This study was conducted to assess and compare the pharmacokinetic (PK) properties, bioavailability of a newly developed dispersible tablet formulation (test) of glucosamine hydrochloride with those of an established branded capsule formulation (reference) in healthy Chinese adult male volunteers.This single-dose, randomized, open-label, 2-period crossover study was conducted in 18 healthy Chinese adult male volunteers under fasting condition. Plasma samples were collected at pre-specified times over a 12-h period following administration in each period and analyzed the plasma glucosamine concentrations by Liquid Chromatography coupled with Tandem Mass Spectrometry (LC/MS/MS) method. The mean (SD) PK parameters of Cmax, Tmax, AUC0-12, and AUC0-∞ after administration of the test and reference formulations were, respectively, as follows: Cmax, 907.01 (444.22) vs. 944.40 (429.89) ng/mL, Tmax, 3.03 (0.95) vs. 3.30 (0.99) hours, AUC0-12, 2891.41 (1352.30) vs. 2889.69 (925.48) ng/mL/h, and AUC0-∞, 3029.90 (1321.36) vs. 3091.87 (870.36) ng/mL/h. The mean (SD) t1/2 was 1.10 (0.52) hours for the test formulation and 1.50 (1.17) hours for the reference formulation. On ANOVA, neither period nor sequence effects were observed for any PK properties. The relative bioavailability of the test formulation was 98.3% assessed by AUC0-12. The 90% CIs of glucosamine for the log-transformed ratios of Cmax, AUC0-12, and AUC0-∞ were 78.4-113.9%, 80.8-108.5% and 80.8-105.8%, respectively, meeting the predetermined criteria for bioequivalence of SFDA.

show abstract

Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants

Cited by 37 publications

References 36 publications

Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Regenerative Injection Therapy for Osteoarthritis: Fundamental Concepts and Evidence‐Based Review

Comparative Fasting Bioavailability and Pharmacokinetic Properties of 2 Formulations of Glucosamine Hydrochloride in Healthy Chinese Adult Male Volunteers

Contact Info

Product

Resources

About