Glucosamine regulation of fibroblast growth factor 21 expression in liver and adipose tissues

Chen, Ting Yu; Sun, David; Lin, Wei Shen; Lin, Yi-Ling; Chao, Yu Ming; Chen, Shan Yu; Chen, Yun‐Ru; Wu, Yuh Lin

doi:10.1016/j.bbrc.2020.06.070

Cited by 14 publications

(17 citation statements)

References 33 publications

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“…To determine the effect of GlcN on hematopoietic reprogramming, GlcN was delivered into C57BL/6 mice using two different methods, i.p. injection according to a previous report ( 20 ) and osmotic pump release for maintaining a steady GlcN concentration ( Figure 1A ). Supplementation with GlcN did not change the body weight or fasting glucose level of the mice after i.p.…”

Section: Resultsmentioning

confidence: 99%

“…D-(+)-Glucosamine hydrochloride dissolved in phosphate-buffered saline (PBS) was administered via an intraperitoneal (i.p.) injection (30 mg/mouse/day) into the mice for 14 days according to a previous report ( 20 ) or implanted subcutaneously using Alzet model 1002 osmotic pumps (1 M, 0.25 μL/h) (DURECT Corp., Cupertino, CA, USA) to maintain a steady GlcN concentration. After 14-day of GlcN treatment, mice were sacrificed with carbon dioxide inhalation.…”

Section: Methodsmentioning

confidence: 99%

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Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Lin

Chen

et al. 2021

Front. Nutr.

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Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both in vivo and in vitro. Additionally, GlcN upregulated the expression of glucose transporter 1 in hematopoietic stem and progenitor cells (HSPCs), influenced HSPC functions, and downregulated key genes involved in myelopoiesis. Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs. We revealed a novel role for GlcN in myelopoiesis and MDSC activity involving a potential link between GlcN and immune system, as well as the new therapeutic benefit.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Lin

Chen

et al. 2021

Front. Nutr.

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“…FGF21 is mainly secreted by the liver, and modulated by glucosamine to improve hepatic glucose metabolism via the nuclear factor kappa B, p38 and protein kinas pathways ( 119 ). In addition, Th2 cytokines interleukin-4 (IL-4) and IL-13 enhance expression of FGF21 to modulate energy metabolism via the IL-4/IL-13-signal transducer and activator of transcription 6 axis in the liver ( 120 ).…”

Section: Factors That Regulate Maternal Hepatic Nutrient Metabolismmentioning

confidence: 99%

Maternal nutrient metabolism in the liver during pregnancy

Fang,

Li,

Wang

et al. 2024

Front. Endocrinol.

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The liver plays pivotal roles in nutrient metabolism, and correct hepatic adaptations are required in maternal nutrient metabolism during pregnancy. In this review, hepatic nutrient metabolism, including glucose metabolism, lipid and cholesterol metabolism, and protein and amino acid metabolism, is first addressed. In addition, recent progress on maternal hepatic adaptations in nutrient metabolism during pregnancy is discussed. Finally, the factors that regulate hepatic nutrient metabolism during pregnancy are highlighted, and the factors include follicle-stimulating hormone, estrogen, progesterone, insulin-like growth factor 1, prostaglandins fibroblast growth factor 21, serotonin, growth hormone, adrenocorticotropic hormone, prolactin, thyroid stimulating hormone, melatonin, adrenal hormone, leptin, glucagon-like peptide-1, insulin glucagon and thyroid hormone. Our vision is that more attention should be paid to liver nutrient metabolism during pregnancy, which will be helpful for utilizing nutrient appropriately and efficiently, and avoiding liver diseases during pregnancy.

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“…Glucosamine (GLC) is an endogenous amino monosaccharide synthesized from glucose and is generally found naturally in cartilage and synovial fluid around joints in the form of sulfate or hydrochloride ( Mendis et al, 2008 ). It is an important molecule in the biochemical pathways for the synthesis of glycosylated proteins and lipids, and is also involved in the biosynthesis of cartilage glycoproteins and glycosaminoglycan ( Chen et al, 2020 ). GLC is one of the most common dietary supplements in the United States, and it can also help treat osteoarthritis ( Qato et al, 2008 ; Liu et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation

Lai,

Zhou,

Bai

et al. 2024

Current Research in Food Science

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Glucosamine regulation of fibroblast growth factor 21 expression in liver and adipose tissues

Cited by 14 publications

References 33 publications

Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Maternal nutrient metabolism in the liver during pregnancy

Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation

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